The effect of age on the presentation of patients with tuberculosis

Chan, Chun‐Hung; Woo, Jean; Or, Koch; Chan, Raymond K. H.; Cheung, Waiman

doi:10.1016/s0962-8479(05)80026-7

Cited by 47 publications

(37 citation statements)

References 10 publications

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“…Diabetes mellitus was also found to be strongly associated with advancing age, in accordance with the findings of other authors, (19,20) who include this disease in the list of those which increase the susceptibility to pulmonary tuberculosis, even causing alterations in the usual radiological aspect of the disease, such as involvement of the lower lobes. (5,20,21) The cardiovascular diseases evaluated in the present study were also strongly associated with being elderly, although no causal relation with pulmonary tuberculosis was established. This might be another confounding factor, since such diseases are quite frequently present in any elderly population and not only in that with pulmonary tuberculosis.…”

Section: Discussioncontrasting

confidence: 51%

Análise do tratamento da tuberculose pulmonar em idosos de um hospital universitário do Rio de Janeiro, RJ, Brasil

2007

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Objective: To describe the clinical and therapeutic aspects of pulmonary tuberculosis and compare the adverse effects of the treatment and its outcome in elderly and nonelderly patients. Methods: This was a case-control study of 117 elderly individuals (over the age of 60 years) and 464 nonelderly individuals (aged 15-49 years). All subjects presented pulmonary tuberculosis that had been diagnosed and treated at the Thoracic Diseases Institute of the Federal University of Rio de Janeiro between 1980 and 1996. Results: In the elderly group, pulmonary tuberculosis was found to be correlated with diabetes (OR = 3.98; 95% CI = 2.07-7.65; p = 0.001), lung disease (OR = 7.24; 95% CI = 3.64-14.46; p = 0.001) and heart disease (OR = 5.86; 95% CI = 2.88-11.95; p = 0.001). Smoking (OR = 2.07; 95% CI = 1.26-3.42; p = 0.002) and alcohol abuse (OR = 1.63; 95% CI = 1.01-2.68; p = 0.041) were also more common in the elderly group. In the elderly group, the treatment more frequently resulted in adverse reactions (OR = 1.62; 95% CI = 1.04-2.54; p = 0.024), especially gastrointestinal reactions (OR = 1.64; 95% CI = 1.01-2.77; p = 0.047), and treatment efficacy was lower: cure rate, 51%; mortality rate, 24%. Treatment adherence was low (approximately 77%) in both groups. Conclusions: In the elderly group, adverse reactions were more common, treatment outcomes were less favorable, there was a greater frequency of clinical complications and deaths related to drug toxicity, and the prevalence of concomitant diseases was higher.

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Section: Discussioncontrasting

confidence: 51%

Análise do tratamento da tuberculose pulmonar em idosos de um hospital universitário do Rio de Janeiro, RJ, Brasil

2007

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“…Three-fourth of the culture positive individuals were aged beyond 50 years old and this might be related to the decline in host immunity as age increases. Chain and colleagues 1995 [53] reported that immunologic abnormalities in elders led to tuberculosis development.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis Infection in Cattle and Cattle Owners in North Eastern Parts of Ethiopia

Mengistu¹,

Enquselassie²

2015

Biol Med (Aligarh)

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Introduction: Ethiopia is one of the highest TB burden countries in the world. Transmission of M. tuberculosis between humans is well known, however, little is known about the transmission of M. tuberculosis complex species between human and animals, in particular cattle. The purpose of this study was, therefore, to investigate the status of bovine tuberculosis infection in cattle owned by tuberculosis suspected households and isolate M. tuberculosis complex species from sputum of chronic coughers in North Wollo Zone of the Amhara National Regional State, Ethiopia. Method:A cross-sectional study was conducted in selected Kebeles of North Wollo Zone. An intradermal tuberculin skin test was carried out on 381 cattle and sputum samples collected from 124 chronic coughers. Sputum samples were cultured and positive ones were identified by polymerase chain reaction using RD4 and RD9 as a marker. Result:Of the 124 sputum samples cultured, 4/ 124 (3.2%) were positive. Polymerase Chain Reaction using has confirmed that 2/4 (50%) were found to be M. tuberculosis while the rest was atypical Mycobacterial species. Of the 381 tested cattle 5/381 (1.31%) and 10/38 (2.63%) were found positive according to manufacturer recommendation (with a cutoff value > 4 mms) and a cutoff value > 2 mms, respectively. About 67% (6/9) of the individuals who owned positive cattle were having the habit of drinking raw milk. Among the ten positives, five of them resided in lowland (Kolla) areas (1300-1500 mabs). However, none of the owners of tuberculin positive cattle were found to be TB positive. Conclusion:This study has shown 3.2% of culture positivity and of these two were found to be M. tuberculosis. The sputum sample culturing from suspected chronically coughing individuals would help detection of the TB causative agents. According to the current findings BTB is considerable in Ethiopia and cattle should be seen as a potential source of zoonotic TB to humans. B io lo g y and M e d ic in e

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“…Auch heute geh6rt sie zu den wichtigen Differentialdiagnosen des unklaren Gewichtsverlustes, ob mit oder ohne subfebrile Temperaturen. Ob ~iltere Patienten ein h6he-res Risiko als jª haben, bei Diagnosestellung Gewicht verloren zu haben, ist umstritten, aberjedenfal!s ist bei ihnen mit atypischen Verl~iufen zu rechnen [6,22]. Die Koinfektion mit HIV ist ebenfalls mit einem h6heren Risiko des Gewichtsverlustes assoziiert [15].…”

Section: Infektionenunclassified

Was ist zu tun bei unklarem Gewichtsverlust?

Schwenk¹

1998

Med Klin

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The effect of age on the presentation of patients with tuberculosis

Cited by 47 publications

References 10 publications

Análise do tratamento da tuberculose pulmonar em idosos de um hospital universitário do Rio de Janeiro, RJ, Brasil

Análise do tratamento da tuberculose pulmonar em idosos de um hospital universitário do Rio de Janeiro, RJ, Brasil

Tuberculosis Infection in Cattle and Cattle Owners in North Eastern Parts of Ethiopia

Was ist zu tun bei unklarem Gewichtsverlust?

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