The effect of age on the fibrinolytic enzyme system

Hamilton, Peter J.; Dawson, Audrey A.; Ogston, D.; Douglas, A. S.

doi:10.1136/jcp.27.4.326

Cited by 41 publications

(8 citation statements)

References 22 publications

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“…However, a previously unreported association between factor VIII levels and leanness is described in elderly males. In a previous study of these volunteers we described a similar negative correlation between obesity and fibrinolytic activity in males (Hamilton, Dawson, Ogston, and Douglas, 1974). It appears that obesity is yet another situation where factor VIII concentrations and fibrinolytic activity are affected in the same direction.…”

Section: Obesity and Coagulation Factorssupporting

confidence: 72%

The effect of age upon the coagulation system

Hamilton¹,

Allardyce²,

Ogston³

et al. 1974

J Clin Pathol

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SYNOPSIS Factors V, VII, VIII, X, XI, and XII of the coagulation system, platelet count, and antithrombin III levels were assayed in 20 healthy volunteers aged 20-40 years and 61 elderly subjects aged 66-96 years whose skinfold thickness was also measured. Factors XI, XII, and antithrombin III levels tended to increase in women and decrease in men while factors X, VII, and V tended to increase in both males and females with advancing years. No age or sex differences were found in platelet counts or factor VIII levels. Factor VIII levels were inversely correlated with obesity in elderly males (r = -0-56, P < 0-005).

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Section: Obesity and Coagulation Factorssupporting

confidence: 72%

The effect of age upon the coagulation system

Hamilton¹,

Allardyce²,

Ogston³

et al. 1974

J Clin Pathol

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“…Plasminogen levels were not found to change with age in one study, except for a decrease for those aged 75 years or older. 66 In contrast, another study reported that plasminogen levels decreased slightly with age in women but not in men. 55 A progressive prolongation of euglobulin lysis time with increasing age has also been reported.…”

Section: Fibrinolytic System Proteins and Agingmentioning

confidence: 92%

Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review

Favaloro

Franchini

Lippi

2014

Semin Thromb Hemost

111

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The incidence of venous thromboembolism (VTE) is well recognized to increase with aging. Concurrently, the plasma concentrations of many coagulation factors (e.g., fibrinogen, factor [F] V, FVII, FVIII, and FIX) increase with aging, as does von Willebrand factor (VWF), thrombin generation, and platelet activation. Data are conflicting regarding age-related changes in the natural anticoagulants, including protein C, protein S, and antithrombin. Changes are also observed with components of the fibrinolytic pathway. All in all, aging is associated with a variety of hemostasis changes that on balance reflects a heightened procoagulant status compared with earlier age. It has to be recognized that as this occurs in the otherwise normal general population, this can also be considered a normal phenomenon of progressive life. An element of this heightened procoagulant status may reflect ongoing inflammatory processes, given some markers, notably FVIII and fibrinogen, are acute phase reactants. A variety of acquired prothrombotic risk factors (e.g., cancer, autoimmune disorders, and diabetes) also gradually develop with aging, some of which may induce profound abnormalities of hemostasis, and confound the age-related changes in hemostasis, as well as their influence on thrombotic risk. In this article, we review the changes in hemostasis markers measurable within many hemostasis laboratories, and consider many of the important implications for clinical and laboratory practice. Apart from representing an increased thrombotic risk, additional considerations entail the potential need (1) to utilize age-adjusted normal ranges (e.g., for D-dimer), (2) to consider the consequence on previous diagnoses (e.g., "mild type 1" von Willebrand disease [VWD], where VWF test results may "normalize" with aging), and (3) to consider the effect of these changes of risk factors on the (perceived) therapeutic efficacy of antithrombotic medications such as aspirin.

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“…In order to investigate the relationship between Fibrino gen levels and thrombin activity in vivo, we measured Fibrinogen and Fibrinopeptide A, a sensitive marker of thrombin activity in vivo, in a group of elderly healthy subjects. In them an increased Fibrinogen concentra tion could be expected, since it is known that Fibrinogen increases with age [7],…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Relationship between High Fibrinogen Levels and Decreased Thrombin Activity in vivo in Elderly Subjects

Marongiu

Mamusa²,

Dessalvi³

et al. 1989

Pathophysiol Haemos Thromb

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In order to investigate whether high fibrinogen levels were associated with elevated thrombin activity, we measured fibrinogen and fibrinopeptide A in 37 elderly healthy subjects ranging from 60 to 93 years. Fibrinogen levels (519.1 ± 127.0 mg/dl) and fibrinopeptide A (5.9, 0.9–18.1 ng/ml) were significantly higher than in younger controls. A highly significant negative linear correlation was found between fibrinogen and fibrinopeptide A in the elderly subjects (p < 0.01). However, a polynomial regression showed that this negative relationship was present at the fibrinogen levels ranging between 420 and 700 mg/dl. Our results suggest that high fibrinogen levels in elderly subjects do not necessarily mean that their thrombin activity is concomitantly increased.

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The effect of age on the fibrinolytic enzyme system

Cited by 41 publications

References 22 publications

The effect of age upon the coagulation system

The effect of age upon the coagulation system

Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review

Evidence for a Relationship between High Fibrinogen Levels and Decreased Thrombin Activity in vivo in Elderly Subjects

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