2013
DOI: 10.1155/2013/598589
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The Effect of Ageing on Nasal Mucociliary Clearance in Women: A Pilot Study

Abstract: Introduction. Pneumonia is the leading infectious cause of death in the elderly. Impaired respiratory defences are one of the causes for increased susceptibility of the elderly to such infections. Nasal mucociliary clearance, the mirror image of bronchial clearance, is crucial in respiratory defence and is affected by various factors. Little is known about the effect of ageing on nasal respiratory epithelium. Aim. To evaluate the effect of ageing on nasal mucociliary clearance (NMC) in women. Materials and Met… Show more

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Cited by 19 publications
(16 citation statements)
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“…All the values fall well within the normal range for a South Indian population and we observed no appreciable increase in NMC time among the overweight and obese compared to the normal BMI group. 12 Among different subcategories of the BMI groups also, we found the mean saccharine transit time to be well within the normal range of values expected. Unexpectedly, we found STT to be shorter in the obese category in all the subgroups.…”
Section: Discussionsupporting
confidence: 73%
“…All the values fall well within the normal range for a South Indian population and we observed no appreciable increase in NMC time among the overweight and obese compared to the normal BMI group. 12 Among different subcategories of the BMI groups also, we found the mean saccharine transit time to be well within the normal range of values expected. Unexpectedly, we found STT to be shorter in the obese category in all the subgroups.…”
Section: Discussionsupporting
confidence: 73%
“…Aging is known to impair mucociliary clearance. Human upper airway ciliary beat frequency (CBF) is slowed with aging (52) and is correlated with prolonged nasal saccharine transit times in women and men (8,22,41). Nasal saccharine transit times, however, may not always correlate with lower respiratory tract mucociliary clearance.…”
Section: Introductionmentioning
confidence: 99%
“…It also facilitates the elimination of particles or bacteria by the mucociliary clearance. Indeed, airway epithelial cells expressed cilia that beat synchronously to allow the clearance of the airway surface liquid (at a speed of 6.9 ± 0.7 mm/min [Hoegger et al, ]) from the lung to the pharynx and from the nose to the pharynx from where the mucus is swallowed (Paul et al, ). This mechanism is considered as the main defence against microorganisms and particles.…”
Section: Colonisation Of the Nasopharynxmentioning
confidence: 99%