The effect of aging on ventricular contractile performance

Urthaler, Ferdinand; Walker, Alfred A.; James, Thomas N.

doi:10.1016/0002-8703(78)90159-x

Cited by 21 publications

(7 citation statements)

References 6 publications

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“…The decrease in LV diastolic performance, also demonstrated by other experimental and clinical studies [15][16][17][18][19][20][21], did not correlate with the increase in LV mass: it must probably be due to age-related changes in LV compliance and relaxation. The latter is negatively in fluenced by a slowing in calcium re-uptake by the sarcoplasmic reticulum, while the increase in myocardial collagen content and the changes in collagen and elastine structure re duce the wall distensibility [22][23][24], The re duction in systolic function with aging found in our males is in accordance with some pre vious experimental and clinical studies [25,26], whereas other authors did not find any significant change in LV systolic performance [11,12]. These conflicting results in our opin ion are related, more than to differences in study groups, to the methods employed.…”

Section: Discussionsupporting

confidence: 84%

Influence of Age and Sex on Left Ventricular Anatomy and Function in Normals

et al. 1992

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Using digitized M-mode echograms, we evaluated the influence of sex on age-related changes of left ventricular (LV) anatomy and function in a normal population (75 males and 75 females, subdivided in age groups for each decade from 20 to 70 years). Aging is accompanied with an increase in septal and wall thickness in both males and females and in LV diameter only in males, with a progressive increase of LV mass more pronounced in males than in females. As regards LV function we found a progressive slowing of relaxation in females and of both contraction and relaxation in males, not related to changes in LV mass.

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Section: Discussionsupporting

confidence: 84%

Influence of Age and Sex on Left Ventricular Anatomy and Function in Normals

et al. 1992

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“…Most studies have shown a de crease in left ventricular relaxation with in creasing age in both sexes. Some studies have shown systolic function to decrease with age in men but not in women [23,24], whereas oth ers have found no change in left ventricular systolic function with increasing age in either men or women [25,26], It has been argued that the baseline systolic blood pressure is rela tively high (120 mm Hg) and the serum creati nine concentration is relatively low in these patients with severe congestive heart failure. However, left ventricular systolic function was not related to blood pressure, furosemide dose or serum creatinine.…”

Section: Discussionmentioning

confidence: 99%

Patient Characteristics in Cases of Chronic Severe Heart Failure with Different Degrees of Left Ventricular Systolic Dysfunction

Eriksson

Kjekshus²,

Offstad³

et al. 1994

Cardiology

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It has not been determined previously whether patients with severe chronic congestive heart failure differ in demographic characteristics with respect to left ventricular systolic dysfunction (LVD). In patients with severe chronic congestive heart failure in NYHA IV, an optional protocol in the CONSENSUS-I trial was designed to ascertain whether there were any differences in patient characteristics regarding the degree of LVD defined as left ventricular fractional shortening (FS). A subgroup of 54 patients from the CONSENSUS-I trial were evaluated with M-mode echocardiography. Patients with FS above median (14%) were older (74 ± 7 vs. 68 ± 7, p < 0.0l), more often female (48 vs. 15%, p < 0.05) and had lower heart rates (77 ± 15 vs. 95 ± 17, p < 0.01). Analysis of the 2-year follow-up from the end of the trial was also performed. In the placebo group, patients with FS > 14% had significantly better prognosis than patients with FS < 14%. In the enalapril-treated group no such difference in survival was seen. The difference between the original treatment groups remained, despite the fact that treatment with enalapril was then made available to all surviving patients. In conclusion, patients with advanced chronic congestive heart failure and less severe LVD have different demographic characteristics than patients with more severe LVD. In the placebo group, but not in the enalapril group, prognosis was better in patients with less severe LVD.

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“…57,[80][81][82] Left ventricular mass will increase with advancing age, 83,84 a factor that may increase myocardial stiffness. 80,85 Nonuniformity of myocardial relaxation may be present to a higher degree with increasing age; thus, diastolic variables may also be affected. 75 With increasing age, the isovolumic-relaxation period is prolonged, 86 the E velocity is decreased, and the A velocity is increased.…”

Section: Mitral Flow Velocitiesmentioning

confidence: 99%

Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical Studies

Nishimura¹,

Abel²,

Hatle³

et al. 1989

Mayo Clinic Proceedings

615

270

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Evaluation of diastolic filling of the heart has been difficult because of its complexity and the numerous interrelated contributing factors. Previous determinations have depended on high-fidelity, invasive measurements of instantaneous pressure, volume, mass, and wall stress, which could not be done on a routine clinical basis. With the advent of Doppler echocardiography, intracardiac blood flow velocities can now be noninvasively assessed. For application of this technique to evaluation of diastolic function in patients with heart disease, it is necessary to understand what the Doppler-derived variables represent. It is also necessary to know how they are affected by changes in loading conditions and changes in myocardial relaxation. In this review, we provide an interpretation of the mitral valve, tricuspid valve, and systemic and pulmonary venous inflow velocities in the normal patient and in various disease states.

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The effect of aging on ventricular contractile performance

Cited by 21 publications

References 6 publications

Influence of Age and Sex on Left Ventricular Anatomy and Function in Normals

Influence of Age and Sex on Left Ventricular Anatomy and Function in Normals

Patient Characteristics in Cases of Chronic Severe Heart Failure with Different Degrees of Left Ventricular Systolic Dysfunction

Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical Studies

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