The effect of aging on auditory components of event-related brain potentials

Schiff, Sami; Valenti, Pietro; Pellegrini, A; Lot, Maria; Bisiacchi, Patrizia; Gatta, Angelo; Amodio, Piero

doi:10.1016/j.clinph.2008.04.007

Cited by 80 publications

(69 citation statements)

References 40 publications

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“…This "frontal aging hypothesis" could be addressed by an impairment of the N100, the MMN and the P3a; we demonstrated that pre-old subjects do not show this psychophysiological feature yet. In another study N100 and MMN were found to be less affected by age than other components such as N2b and P3b [36]. The stability of auditory discrimination and novelty processing in aging was found despite a lower level of education in comparison to young adults.…”

Section: Young Adultsmentioning

confidence: 90%

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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Abstract. Complex higher-order cognitive functions and their possible changes with aging are mandatory objectives of cognitive neuroscience. Event-related potentials (ERPs) allow investigators to probe the earliest stages of information processing. N100, Mismatch negativity (MMN) and P3a are auditory ERP components that reflect automatic sensory discrimination. The aim of the present study was to determine if N100, MMN and P3a parameters are stable in healthy aged subjects, compared to those of normal young adults. Normal young adults and older participants were assessed using standardized cognitive functional instruments and their ERPs were obtained with an auditory stimulation at two different interstimulus intervals, during a passive paradigm. All individuals were within the normal range on cognitive tests. No significant differences were found for any ERP parameters obtained from the two age groups. This study shows that aging is characterized by a stability of the auditory discrimination and novelty processing. This is important for the arrangement of normative for the detection of subtle preclinical changes due to abnormal brain aging.

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Section: Young Adultsmentioning

confidence: 90%

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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“…However, the value of P300 prolongation as a marker of the risk of the occurrence of overt HE in the follow up was found to be lower than that of the EEG (positive predictive value 53 vs. 75%, negative predictive value 81 vs. 86%). 77 In addition, the clinical usefulness of this tool is limited by the followings: i) P300 latency is age-related, 79 and therefore studies based on fixed cut off values are biased, ii) a relevant (5-10%) proportions of individuals-also healthy subjects-do not produce a reliable P300. Usually P300 is computed by the averaging of a number of trials; however, it is possible to compute P300 also on single trials.…”

Section: Motor Evoked Potentials (Meps)mentioning

confidence: 99%

“…81 In conclusion, despite its theoretical interest, P300 latency is not recommended as a routine technique to detect and monitor minimal or covert HE by the 'International Society for Hepatic Encephalopathy and Nitrogen Metabolism' (ISHEN) consensus. 82 Recently mismatch negativity was proposed as a good diagnostic tool for minimal HE, also because it is independence of age 79 and reflects a precocious phase of the attentional processes, and these are altered in minimal HE. 83 The clinical use of this potential is even more difficult and problematic than that of P300, since its elicitation is not constant and its measurement difficult.…”

Section: Motor Evoked Potentials (Meps)mentioning

confidence: 99%

Clinical Neurophysiology of Hepatic Encephalopathy

Amodio

Montagnese

2015

Journal of Clinical and Experimental Hepatology

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Background/Objectives: Hepatic encephalopathy (HE) has relevant impact on the quality of life of patients and their caregivers and causes relevant costs because of hospitalizations and work days lost. Its quantification is important to perform adequate clinical trials on this relevant complication of cirrhosis and portal-systemic shunting. Clinical neurophysiology, which detects functional alterations of the nervous system, has been applied to the study of HE for over 60 years. This review aims at summarizing and clarifying the role of neurophysiologic techniques in the study of HE. Methods: A narrative review was performed aiming at interpreting the cited papers and the techniques on the basis of their physiological and pathophysiological meaning. Results: The potential role of EEG, quantified EEG, evoked potentials-both exogenous, endogenous and motor-have been clarified to the reader that may be unfamiliar with neurophysiology. Conclusions: The EEG, reflecting the oscillatory changes of neural network is the preferable tool to detect and monitor HE, with the exception of its most severe stage, when EEG flattens. SSEP and MEP have indication to detect and monitor transmission alterations that are likely related to myelin changes and microedema. ( J CLIN EXP HEPATOL 2014;5:S60-S68)

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“…These are referred to as brainstem auditory evoked potentials (BAEP) and visual evoked potentials (VEP), and BAEP are used more frequently. In addition, comparative analysis of neuropsychological and neurophysiological P300 tests showed a statistically significant correlation, with high specificity and sensitivity (79)(80)(81)(82)(83). Changes of CEP P300 are characterized by extended latency and low wave amplitude.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, neurophysiological tests with CEP P300 are gaining attention (79)(80)(81). During the testing procedure, both auditory and visual stimuli are used.…”

Section: Discussionmentioning

confidence: 99%

P300 as an auxiliary method in clinical practice: A review of literature

Titlić

Mihalj

Petrovic

et al. 2016

JHSCI

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Cognitive functions can be assessed and followed up over a period of time with cognitive evoked potentials (CEP) P300� In this context, brainstem auditory evoked potentials (BAEP) are most commonly used, but visual evoked potentials (VEP) are utilized as well� The research in this area has demonstrated that these techniques could be used as a supplemental method in diagnostics of numerous diseases such as Alzheimer's disease, mild cognitive impairment, vascular dementia, epilepsy, craniocerebral trauma, Parkinson's disease, multiple sclerosis, and other degenerative diseases� In addition, P300 can also be used as an auxiliary method in the diagnostics of mental disorders conditions such as schizophrenia, panic disorders, narcotic drug addiction, nicotinism, alcoholism, etc� The method assists in monitoring the course of diseases leading to encephalopathy, such as liver and kidney damage and grave anaemia� The advantages of P300 testing are easy application, non-invasiveness, and an unlimited number of potential applications� Moreover, the results obtained with this method are measurable and can be compared�

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The effect of aging on auditory components of event-related brain potentials

Cited by 80 publications

References 40 publications

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Clinical Neurophysiology of Hepatic Encephalopathy

P300 as an auxiliary method in clinical practice: A review of literature

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