The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Jaja, Abdullah Al; Grahn, Jessica A.; Herrmann, Björn; MacDonald, Penny A.

doi:10.1101/647628

Cited by 3 publications

(9 citation statements)

References 65 publications

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“…Hence, although neural responses to the onset of sound was enhanced in older adults, neural sensitivity to a pattern in sounds was reduced. Diminished sustained activity for older compared to younger adults is consistent with previous indications of an age-related reduction in sustained activity for short (<1 s) pure tones (Pfefferbaum et al, 1979), amplitude modulations (Herrmann et al, 2019), and repeated patterns in tone sequences (Al Jaja et al, 2020). However, low statistical reliability and differences in stimulus parameters between age groups did not allow drawing firm conclusions from the latter two studies.…”

Section: Discussionsupporting

confidence: 89%

“…More recent work indicates that younger individuals exhibit pattern-related sustained activity in response to amplitude-modulated sounds, whereas older adults do not appear to, although the difference between these groups was not significant (Herrmann et al, 2019). Another study yielded data suggestive of reduced sustained activity in older compared to younger people in response to repeated tone sequences (Al Jaja et al, 2020), but stimulus parameters differed between age groups in this paper. A controlled experiment with sufficient power is thus required to elucidate whether sustained neural activity to regular sound patterns differs between younger and older people.…”

Section: Introductionmentioning

confidence: 62%

“…Previous work investigating sustained neural activity in older adults has utilized low-density electroencephalography (EEG; fewer than 20 electrodes; Pfefferbaum et al, 1979; Herrmann et al, 2019; Al Jaja et al, 2020). This type of EEG is not very well suited for the localization of neural sources generating scalp-recorded signals.…”

Section: Introductionmentioning

confidence: 99%

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A Neural Signature of Regularity in Sound is Reduced in Older Adults

Maeß

Johnsrude²

2021

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Sensitivity to repetitions in sound amplitude and frequency is crucial for sound perception. As with other aspects of sound processing, sensitivity to such patterns may change with age, and may help explain some age-related changes in hearing such as segregating speech from background sound. We recorded magnetoencephalography to characterize differences in the processing of sound patterns between younger and older adults. We presented tone sequences that either contained a pattern (made of a repeated set of tones) or did not contain a pattern. We show that auditory cortex in older, compared to younger, adults is hyperresponsive to sound onsets, but that sustained neural activity in auditory cortex, indexing the processing of a sound pattern, is reduced. Hence, the sensitivity of neural populations in auditory cortex fundamentally differs between younger and older individuals, overresponding to sound onsets, while underresponding to patterns in sounds. This may help to explain some age-related changes in hearing such as increased sensitivity to distracting sounds and difficulties tracking speech in the presence of other sound.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 62%

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A Neural Signature of Regularity in Sound is Reduced in Older Adults

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Johnsrude²

2021

Preprint

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“…The original degrees of freedom, epsilon coefficient, and corrected p-value are reported. All participants were included in the analysis of the sustained response, since the more intense stimuli presented to older people would lead to larger responses, if anything, and we hypothesized that sustained activity would be reduced in older compared to younger adults (Pfefferbaum et al, 1979; Al Jaja et al, 2020; Herrmann et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…For example, short pure tones elicited a smaller sustained response in older compared to younger adults (Pfefferbaum et al, 1979). The sustained neural response elicited by repeated sets of tones in longer tone sequences has also been shown to be reduced for older relative to younger adults (Al Jaja et al, 2020; Herrmann et al, 2022). A similar age-related reduction in the sustained response has been reported in an EEG study for low-frequency amplitude modulations (Herrmann et al, 2019), although the effect of age group (younger vs older) was only marginally significant in this study.…”

Section: Introductionmentioning

confidence: 99%

Sustained responses and neural synchronization to amplitude and frequency modulation in sound change with age

Herrmann

Maeß

Johnsrude

2022

Preprint

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Perception of speech requires sensitivity to features, such as amplitude and frequency modulations, which are often temporally regular. Previous work suggests age-related changes in neural responses to temporally regular features, but little work has focused on age differences for different types of modulations. We recorded magnetoencephalography in younger (21–33 years) and older adults (53–73 years) to investigate age differences in neural responses to slow (2-6 Hz sinusoidal and non-sinusoidal) modulations in amplitude, frequency, or combined amplitude and frequency. Neural responses to sound onset (independent of temporal modulations) were enhanced in older compared to younger adults, suggesting hyperresponsivity and a loss of inhibition in the aged auditory system. Analyses of neural activity to modulations revealed enhanced neural synchronization with amplitude, frequency, and combined amplitude-frequency modulations for older compared to younger adults. This enhancement generalized across different degrees of temporal regularity (sinusoidal and non-sinusoidal), although neural synchronization was generally lower for non-sinusoidal modulation. Despite enhanced synchronization, sustained neural activity was reduced in older compared to younger adults for sounds modulated both sinusoidally and non-sinusoidally in frequency. Our results suggest substantial age differences in the sensitivity of the auditory system to features present in speech and other natural sounds.

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Dopamine dysregulation in Parkinson’s disease flattens the pleasurable urge to move to musical rhythms

Pando‐Naude

Matthews

Højlund

et al. 2023

Preprint

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The pleasurable urge to move to music (PLUMM) elicits activity in motor and reward areas of the brain and is thought to be driven by predictive processes. Dopamine within motor and limbic cortico-striatal networks is implicated in the predictive processes underlying beat-based timing and music-induced pleasure, respectively. This suggests a central role of cortico-striatal dopamine in in PLUMM. This study tested this hypothesis by comparing PLUMM in Parkinson's disease patients, healthy age-matched, and young controls. Participants listened to musical sequences with varying rhythmic and harmonic complexity (low, medium, high), and rated their experienced pleasure and urge to move to the rhythm. In line with previous results, healthy younger participants showed an inverted U-shaped relation between rhythmic complexity and ratings, with a preference for medium complexity rhythms, while age-matched controls showed a similar, but weaker, inverted U-shaped response. Conversely, PD patients showed a significantly flattened response for both the urge to move and pleasure. Crucially, this flattened response could not be attributed to differences in rhythm discrimination and did not reflect an overall decrease in ratings. Together, these results support the role of dopamine within cortico-striatal networks in the predictive processes that form the link between the perceptual processing of rhythmic patterns, and the affective and motor responses to rhythmic music.

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The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Cited by 3 publications

References 65 publications

A Neural Signature of Regularity in Sound is Reduced in Older Adults

A Neural Signature of Regularity in Sound is Reduced in Older Adults

Sustained responses and neural synchronization to amplitude and frequency modulation in sound change with age

Dopamine dysregulation in Parkinson’s disease flattens the pleasurable urge to move to musical rhythms

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