The Effect of Alcohol Intoxication on Mortality of Blunt Head Injury

Abstract

Alcohol is found to have neuroprotection in recent studies in head injuries. We investigated the association of blood alcohol concentration (BAC) with mortality of patients with blunt head injury after traffic accident. All patients sustaining blunt head injury caused by traffic accident brought to our emergency department who had obtained a brain computed tomography scans and BAC were analyzed. Patients with unknown mechanisms, transfers from outside hospitals, and incomplete data were excluded. Logistic regression was used to identify independent predictors of mortality. During the study period, 3,628 patients with brain computed tomography (CT) were included. Of these, BAC was measured in 556 patients. Patients with the lowest BAC (less than 8 mg/dl) had lower mortality; intoxicated patients with BAC between 8 and less than 100 mg/dl were associated with significantly higher mortality than those patients in other intoxicated groups. Adjusted logistic regression demonstrated higher BAC group and Glasgow coma scale (GCS) scores, and lower ISS and age were identified as independent predictors of reduced mortality. In our study, we found that patients who had moderate alcohol intoxication had higher risk of mortality. However, higher GCS scores, lower ISS, and younger age were identified as independent predictors of reduced mortality in the study patients.

Acute Alcohol Exposure and Risk of Mortality of Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis

“…). A borderline significant link was found when we omitted Gururaj's () study (OR = 0.90, 95% CI = 0.82 to 0.99), Puljula and colleagues () study (OR = 0.90, 95% CI = 0.82 to 0.99), Pandit and colleagues () (OR = 0.90, 95% CI = 0.82 to 0.99), or Lin and colleagues () study (OR = 0.89, 95% CI = 0.81 to 0.97). The other results of sensitivity analysis for different BACs were not altered.…”

“…Eighteen observational studies containing a total of 48,537 (37%) patients with positive BAC and 82,487 (63%) patients with negative BAC were ultimately included, and the mortality rates were analyzed in this meta‐analysis (Alexander et al., ; Berry et al., , ; Brennan et al., ; Chamoun et al., ; Chen et al., ; Gururaj, ; Hsieh et al., ; Levy et al., ; Lin et al., ; Lustenberger et al., ; Pandit et al., ; Raj et al., ; Salim et al., ,; Shandro et al., ; Tien et al., ). The overall mortality rate, the mortality rate of BAC‐positive subjects, and the mortality rate of BAC‐negative subjects, all with TBI, were 13.2%, 12.4%, and 13.7%, respectively.…”

“…A statistically significant link was observed between low BAC (1 to 100 mg/dl) and high BAC (>230 mg/dl); the pooled OR was 1.76 (95% CI = 1.34 to 2.30, I 2 = 12.1%, p for heterogeneity >0.1). Three studies (Berry et al., ; Lin et al., ; Shandro et al., ) with a cohort of 2,252 provided necessary information to estimate the risk of mortality between moderate BAC (100 to 230 mg/dl) and high BAC (>230 mg/dl), and the result indicated that there was no significant difference in the risk of mortality between moderate and high BAC (OR = 1.20, 95% CI = 0.89 to 1.63; I 2 = 0%, p for heterogeneity >0.1).…”

“…The effect of alcohol exposure on the outcomes of TBI patients has attracted increasing interest. Although a number of observational clinical studies have been conducted, the results remain ambiguous (Berry et al., ; Lin et al., ; Salim et al., ). Considering this confusing situation, Raj and colleagues () performed a meta‐analysis and found that positive BAC was significantly associated with a lower mortality rate.…”

Tudjuk, hol a határ? – A Sürgősségi Betegellátó Osztályt akut alkoholintoxikáció miatt felkereső betegek ellátásának elemzése

“…Az alkohollal összefüggésbe hozható betegségek a nők és a férfiak körében nagyon különböző arányt mutatnak (férfiak: 7,4%, nők: 2,3%) [3,9,11,18,19]. Vizsgálatunkban ez a különbség a szakirodalommal megegyező, azonban kutatásunkban nagyobb számban fordulnak elő társbetegségek (férfiak: 33,4%, nők: 29,5%) [3,18,19].…”