The effect of alfalfa saponins on the contractility of bovine isolated abomasum and duodenum preparations

Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

“…The predominant influence of PSM on final type and size of interactions can be explained by their nonspecific mechanism of action on gastrointestinal smooth muscles. As proposed before, both flavonoids and saponins interfere with the structure of smooth muscle cell membranes, change their permeability and depolarization status and consequently reactivity to other agents (Ma & Xiao, ; Dar & Channa, ; Mendel et al., , ). The nonspecific effect of the tested phytocompounds on gut smooth muscle explains the ability to change strips’ response to pharmaceutical agents of different modes of action.…”

“…Therefore, the study herein was focused on the interactions of PSM in nonsugar form with pharmaceutical agents. Our previous findings indicated that apigenin and quercetin as well as hederagenin and medicagenic acid significantly affect the contractility of bovine abomasum and duodenum smooth muscle (Mendel et al., , ). Therefore, we hypothesized that all of previously tested PSM might be able to modify the effect of pharmaceutical agents which are known to affect gastrointestinal motoric activity.…”

“…Our previous findings indicated that apigenin and quercetin as well as hederagenin and medicagenic acid significantly affect the contractility of bovine abomasum and duodenum smooth muscle (Mendel et al, 2016a(Mendel et al, , 2016b. Therefore, we hypothesized that all of previously tested PSM might be able to modify the effect of pharmaceutical (Nouri et al, 2008;Wittek et al, 2008;Fazeli, Shomali, Firouzi, & Ghane, 2012) in addition to the main activity, that is, antibacterial, anti-inflammatory and anthelminthic, respectively.…”

“…The cholinergic stimulatory property of levamisole is reflected in our results where the drug increased the response to ACh in both abomasal and duodenal specimens (Figure 3). and consequently reactivity to other agents (Ma & Xiao, 1998;Dar & Channa, 1999;Mendel et al, 2016aMendel et al, , 2016b. The nonspecific effect of the tested phytocompounds on gut smooth muscle explains the ability to change strips' response to pharmaceutical agents of different modes of action.…”

Effects of Urtica cannabina to Leymus chinensis Ratios on Ruminal Microorganisms and Fiber Degradation In Vitro

“…To our knowledge, an unconventional forage with a high nutritive values can be used as alternative feed source for ruminant animals [6,7]. High-quality forages rich in bioactive ingredients, such as saponins, which are widely distributed in alfalfa and clover, have been shown to improve the gastrointestinal development and nutrient metabolism of ruminants [8,9]. Concretely, Urtica cannabina L., which is widely distributed herbaceous group of stipules in China, is an unconventional forage.…”