The Effect of Alkaloidal Fraction from Annona squamosa L. against Pathogenic Bacteria with Antioxidant Activities

Shami, Abdul-Mushin M

doi:10.15171/ps.2017.44

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…A. squamosa alkaloids have been studied for their various biological activities. They exhibit antibacterial, antioxidant, and cytotoxic activity (34,35). 6, 7-Dimethoxy-1-(α-hydroxy-4methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline and coclaurine showed excellent cytotoxic activity against HepG-2, MCF-7, and HCT-116 cell lines.…”

Section: Alkaloidsmentioning

confidence: 99%

Annona squamosa L.: A promising herbal remedy - Insights into its biological activities and phytochemical composition

Shokr,

Elsohafy,

Darwish

et al. 2024

Journal of Advanced Pharmaceutical Sciences

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Annonaceae is a large, prominent family within the Magnoliales order, containing many genera. Among these, the genus Annona holds significance for its substantial diversity and traditional medicinal value. Annona squamosa L. is one of the most common species of this genus. This tropical species, commonly known as the sugar apple, exhibits distinct morphological features. Phytochemical investigations of A. squamosa revealed the presence of acetogenins, alkaloids, diterpenes, and cyclopeptides in various plant parts. Acetogenins, found mainly in seeds and representing the major active constituents, possess distinctive structures and biological activities. Alkaloids, predominantly isolated from leaves, represent the second major class of A. squamosa active constituents. A. squamosa exhibits a wide array of pharmacological activities encompassing anti-tumor, anti-inflammatory, antioxidant, antidiabetic, antimicrobial, antiviral, immunomodulatory, and wound-healing properties. This comprehensive review highlights the botanical characteristics, phytochemical composition, and diverse pharmacological activities of A. squamosa and aims to be a guide for further research on A. squamosa.

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Section: Alkaloidsmentioning

confidence: 99%

Annona squamosa L.: A promising herbal remedy - Insights into its biological activities and phytochemical composition

Shokr,

Elsohafy,

Darwish

et al. 2024

Journal of Advanced Pharmaceutical Sciences

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“…Reticuline, o-methylarmepavine, annonaine, oxophoebine, lysicamine, n-methylcoclaurine, liriodenine, corydine, lanuginosine, roemerine, corypalmine, sanjoinine, norlaureline, norcodeine, oxalanobie, aporphine [75,[116][117][118] Seed Annonaine, asimilobine, liriodenine, corypalmine, reticuline, nornuciferine [119] Stem bark Roemerolidine, N-nitrosoxylopine, duguevalline…”

Section: Leafmentioning

confidence: 99%

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

Fuentes

Montalvo‐González

Magaña

et al. 2021

Plants

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The Annonaceae family is one of the oldest angiosperms. The genus Annona is the one with the most species and, together with Asimina, the only ones that contain edible fruits. In the last 10 years, interest in these fruit species has increased, mainly due to their nutritional properties and their application in the treatment of human diseases. Mexico is the center of origin for most of them. However, at present much of the basic agronomic information, postharvest handling of the fruits, and their potential as new crops for areas with poor soils in organic matter or semi-dry climates is unknown. It is considered that these custard apple species may be an option to change towards instead of crops that have lost profitability and sustainability. A review of the current state of knowledge in different areas of the species A. muricata, A. macroprophyllata, A. reticulata, A. squamosa, and A. cherimola was carried out and to focus research efforts on the topics of greatest interest and on those where is required to achieve a sustainable production and use of these resources in Mexico. However, knowledge about the cultivation and potential uses of these species is needed to increase their commercialization; the integration of interdisciplinary and interinstitutional groups is required.

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“…According to numerous literature reviews in C. inermehave an alkaloid in leaves (17)(18)(19). These substances have antibacterial and other biological effects (20)(21).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Study of antibacterial and antioxidant activities of alkaloids fraction from Clerodendron inerme leaves

Shami¹,

Saadedin²,

Hasan³

2020

ATMPH

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Clerodendron inerme is used for the treatment for many diseases such as dysentery, heart diseases, AIDS, cancers, and others. Aim of this research was to determine the antibacterial and antioxidant activities the leaf alkaloids of Clerodendron inerme. To evaluate the antibacterial effects, Well diffusion assay, minimum inhibitory concentration and the minimum bactericidal concentration were used to test antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa.For antioxidant activity, DPPH radical scavenging activity assay was used a standard method. GC-MS analysis was used to identify alkaloids. Alkaloid component from the leaves of C. inerme exhibited significant inhibition zones on the tested bacteria including P.aeruginosa. Alkaloid extracted from the leaves of the plant has high antioxidant activity compared to the control (Ascorbic acid).GC-MS resultsidentified. 1-Methylspermidine, Spermidine hydrochloride, sym-Homo Spermidine-d, Trihydrochloride, spermine, 6-Methyl-2-phenyl-quinoline, indeno[1,2b]quinolizine, 1-Methyl-1H-indole-2-carboxylic acid, 1H-Indole-3-carboxylic acid, 2,6-Octadiene-1,8-diamine and 2-phenylindol-3-one. It can be concluded that the alkaloids of the leaves of the plant have a good antibacterial and antioxidant properties.The results indicate that the alkaloids appear in C. inerme leaves can be a new source of antimicrobialsagents against pathogenic bacteria and antioxidant sources.

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The Effect of Alkaloidal Fraction from Annona squamosa L. against Pathogenic Bacteria with Antioxidant Activities

Cited by 5 publications

References 23 publications

Annona squamosa L.: A promising herbal remedy - Insights into its biological activities and phytochemical composition

Annona squamosa L.: A promising herbal remedy - Insights into its biological activities and phytochemical composition

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

Study of antibacterial and antioxidant activities of alkaloids fraction from Clerodendron inerme leaves

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