The effect of Alpha‐lipoic acid supplementation on endothelial function: A systematic review and meta‐analysis

Jalilpiran, Yahya; Hajishafiee, Maryam; Khorshidi, Masoud; Rezvani, Hamid; Mohammadi-Sartang, Mohsen; Rahmani, Jamal; Mousavi, Seyed Mohammad

doi:10.1002/ptr.6959

Cited by 9 publications

(6 citation statements)

References 53 publications

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“…ALA exerts its antioxidant power in several ways, which include reducing and regenerating oxidized endogenous antioxidants such as glutathione, vitamin C, and vitamin E, purifying reactive oxygen species (ROS) and nitrogen species (RNS), and modulating the signaling pathways for the nuclear factor kappa B (NF- κ B) 53 , 54 . In addition, the protective effect of ALA on endothelial function has been shown in previous studies 55 – 57 . Evidence confirms the safety of ALA supplementation in various health conditions in children and adults 58 .…”

Section: Introductionsupporting

confidence: 61%

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

Kelishadi

Naeini

Khorvash

et al. 2022

Sci Rep

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The current study was performed to evaluate the effects of alpha-lipoic acid (ALA) supplementation on lactate, nitric oxide (NO), vascular cell adhesion molecule-1 (VCAM-1) levels, and clinical symptoms in women with episodic migraines. Considering the inclusion and exclusion criteria, ninety-two women with episodic migraines participated in this randomized, double-blind, placebo-controlled, parallel-design trial. The participants were randomly assigned to receive either 300 mg/day ALA or placebo, twice per day for 12 weeks. The primary outcomes included headache severity, headache frequency per month, and duration of attacks and the secondary outcomes included lactate (a marker of mitochondrial function), NO, and VCAM-1 serum levels were measured at baseline and the end of the intervention. At the end of the study, there was a significant decrease in lactate serum levels (− 6.45 ± 0.82 mg/dl vs − 2.27 ± 1.17 mg/dl; P = 0.039) and VCAM-1 (− 2.02 ± 0.30 ng/ml vs − 1.21 ± 0.36 ng/ml; P = 0.025) in the ALA as compared to the placebo group. In addition, the severity (P < 0.001), frequency (P = 0.001), headache impact test (HIT-6) (P < 0.001), headache dairy results (HDR) (P = 0.003), and migraine headache index score (MHIS) (P < 0.001) had significantly decreased in the intervention as compared to the control group. No significant changes were observed for NO levels and duration of migraine pains. ALA supplementation can be considered a potential adjunct treatment in patients with migraine due to its improving mitochondrial and endothelial functions and clinical symptoms.

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Section: Introductionsupporting

confidence: 61%

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

Kelishadi

Naeini

Khorvash

et al. 2022

Sci Rep

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“…It is commonly known that the LA/DHLA system inhibits NF k B signaling with a decrease in pro-inflammatory cytokine secretion. Moreover, by preventing the oxidative depletion of tetrahydrobiopterin (BH4), an essential cofactor for the production of NO by the NO synthases (NOS), LA can restore the NOS activity resulting in an increase in NO bioavailability, and thus, it can improve the endothelial function [ 129 ]. It is also necessary to remember that the LA/DHLA system can directly scavenge the ROS or can restore the reduced form of GSH and other antioxidants, thus enhancing endogenous antioxidant protection.…”

Section: Lipoic Acid (La) and Covid-19mentioning

confidence: 99%

Reactive Sulfur Compounds in the Fight against COVID-19

et al. 2022

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The SARS-CoV-2 coronavirus pandemic outbreak in 2019 resulted in the need to search for an effective and safe strategy for treating infected patients, relieving symptoms, and preventing severe disease. SARS-CoV-2 is an RNA virus that can cause acute respiratory failure and thrombosis, as well as impair circulatory system function. Permanent damage to the heart muscle or other cardiovascular disorders may occur during or after the infection. The severe course of the disease is associated with the release of large amounts of pro-inflammatory cytokines. Due to their documented anti-inflammatory, antioxidant, and antiviral effects, reactive sulfur compounds, including hydrogen sulfide (H2S), lipoic acid (LA), N-acetylcysteine (NAC), glutathione (GSH), and some other lesser-known sulfur compounds, have attracted the interest of scientists for the treatment and prevention of the adverse effects of diseases caused by SARS-CoV-2. This article reviews current knowledge about various endogenous or exogenous reactive sulfur compounds and discusses the possibility, or in some cases the results, of their use in the treatment or prophylaxis of COVID-19.

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“…Moreover, recent meta-analyses suggest that, apart from its favorable effects on diabetic neuropathy, ALA supplementation improves endothelial function and glycemic control and reduces weight, inflammatory biomarkers, triglycerides, total cholesterol, and LDL cholesterol [48][49][50][51][52].…”

Section: Lipoic Acidmentioning

confidence: 99%

The Role of Biofactors in Diabetic Microvascular Complications

Ziegler

Porta

Παπάνας

et al. 2022

CDR

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: Microvascular complications are responsible for a major proportion of the burden associated with diabetes contributing to substantial morbidity, mortality, and healthcare costs in people with diabetes. Retinopathy, nephropathy, and neuropathy constitute the leading causes of blindness, end-stage renal disease, and lower-extremity amputations, respectively. Since the efficacy of causal therapies of diabetic microvascular complications is limited, especially in type 2 diabetes, there is an unmet need for adjunct treatments which should be effective despite ongoing hyperglycemia. Experimental studies indicate that diabetic microvascular complications can be prevented or ameliorated by various biofactors in animal models by interfering with the pathophysiology of the underlying condition. Some of the findings related to biofactors like α-lipoic acid and benfotiamine could be translated into the clinical arena and confirmed in clinical trials, especially in those focusing on diabetic polyneuropathy. Given the micronutrient nature of these compounds, their safety profile is excellent. Thus, they have the potential to favorably modify the natural history of the underlying complication, but large long-term clinical trials are required to confirm this notion. Ultimately, biofactors should expand our therapeutic armamentarium against these common, debilitating, and even life-threatening sequelae of diabetes.

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The effect of Alpha‐lipoic acid supplementation on endothelial function: A systematic review and meta‐analysis

Cited by 9 publications

References 53 publications

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

Reactive Sulfur Compounds in the Fight against COVID-19

The Role of Biofactors in Diabetic Microvascular Complications

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