The Effect of Alprenolol and Alprenolol in Combination With Saluretics in Hypertension

Abstract

The effects of saluretic diuretics, alprenolol and these agents combined have been investigated in 23 patients with mild or moderately severe hypertension. Mean age was 60 years (range 43–75 years). The results of the study show that: Alprenolol in a dose of 426 mg daily gave the same reduction of diastolic pressure as previous treatment with diuretics. In order to achieve the same reduction of systolic pressure a mean dose of 700 mg alprenolol daily was required. The combination saluretic diuretics and alprenolol appears to give re‐inforcement of the antihypertensive effect as combination of 1/4 of the dose of each agent gave equally good control of the blood pressure as the full dose of either agent alone. Some increase of serum uric acid was observed during the treatment with the higher dose of alprenolol. Slight weight gain was observed during all alprenolol periods. Potassium substitution was given only during diuretic periods but despite this the serum potassium levels were higher during treatment with alprenolol. The combination provides a good alternative for the treatment of raised blood pressure.

The use of diuretics in modern antihypertensive therapy

“…The efficacy and tolerability of such a combined regimen is evident and thiazide diuretics together with P-adrenoceptorblocking drugs are widely used. Half the dosage of these two compounds in combination therapy provides ; I superior hypotensive effect compared with the nornial dose of each drug in single therapy (Angervall & Bystedt 1974).…”

Long‐term Effect of Alprenolol as Antihypertensive Agent

“…,9-adrenergic blocking agents are in common use in the treatment of arterial hypertension, both as sole antihypertensive agent (3, 4) and in combination with other antihypertensive drugs such as hydralazine (9,12) and saluretic diuretics (2,8,14). A previous double-blind crossover study showed that chlorthalidone (Hygroton@) 50 mg daily reduced blood pressure (BP) significantly more than alprenolol (Aptin@) 100 mg q. i. d., while chlorthalidone 50 mg daily and alprenolol (Aptin@ Durules") 400 mg b. i. d. seemed to have a similar BP reducing effect (3).…”

A Comparative Study of Alprenolol and Α‐methyldopa Respectively in Combination With Chlorthalidone in Hypertension

“…If this does not produce satisfactory control of the blood pressure a-methyldopa is then often added until the blood pressure is well controlled. B-adrenergic blocking agents have also proved effective in combination with a saluretic diuretic (1,3,8). In the present study the antihypertensive effect of a-methyldopa (Sem-brina@') is compared with the adrenergic p-receptor blocker alprenolol (Aptin@) in patients with essential hypertension, all of whom received a saluretic diuretic (chlorthalidone) in a low but constant dosage throughout the study.…”