The Effect of Amlodipine Combined with Atorvastatin on the Levels of HMGB-1 and YKL-40 in Patients with Coronary Heart Disease and Carotid Atherosclerosis

Abstract

To observe the incidence of adverse reactions of amlodipine combined with atorvastatin in patients with coronary heart disease complicated with carotid atherosclerosis and the effect on the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39. Retrospective analyses of patients with coronary heart disease combined with carotid atherosclerosis in our hospital are divided into two groups according to different treatment methods. The control group was given atorvastatin and the observation group was given amlodipine on this basis. The differences in blood lipid levels, myocardial enzyme levels, intima-media thickness levels, high-mobility group box protein 1 and human cartilage glycoprotein 39 changes before and after treatment were compared between the two groups. During the treatment period, there was no difference in the incidence of complications between the two groups. There was no difference in blood lipid levels between the two groups before treatment. After treatment, the levels of low-density lipoprotein cholesterol, triglycerides and total cholesterol in the observation group were lower than those in the control group and the levels of high-density lipoprotein cholesterol were higher than those in the control group. There was no difference in intima-media thickness before treatment between the two groups. At 4 and 8 w after treatment, the intima-media thickness value of the observation group was lower than that of the control group (p<0.05). There was no difference in the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39 between the two groups before treatment. After treatment, the levels of high-mobility group box protein 1 and human cartilage glycoprotein 39 in the observation group were lower than those in the control group (p<0.001). There was no difference in myocardial enzyme indexes between the two groups before treatment. After treatment, the levels of lactate dehydrogenase and creatine kinase myocardial band of the two groups were lower than before treatment and the observation group was lower than the control group, the difference was statistically significant (p<0.001). Amlodipine combined with atorvastatin has a good therapeutic effect on patients with coronary heart disease complicated with carotid atherosclerosis and has good application value.