The effect of an energy drink containing glucose and caffeine on human corticospinal excitability

Specterman, Mark; Bhuiya, Anwarul Kabir; Kuppuswamy, Annapoorna; Strutton, Paul H.; Catley, Maria; Davey, Nick J.

doi:10.1016/j.physbeh.2004.09.008

Cited by 36 publications

(35 citation statements)

References 19 publications

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“…One possibility would be to individualize rTMS treatment parameters, namely frequency, intensity (12, 20) and/or the stimulation paradigm proper (e.g., theta burst stimulation (56)), in order to identify the conditions that induce sufficient corticospinal excitability modulation. If, as proposed above, MDD patients are less sensitive to the neuromodulatory effects of MC rTMS than healthy subjects, another possibility would be to increase the likelihood of excitability modulation by rTMS, for example using concomitant interventions that may independently enhance cortical excitability, such as ketamine, caffeine or glucose (55, 57). Nevertheless, these proposals are speculative, and randomized trials will be required to compare antidepressant outcomes between current standard rTMS treatment and individualized or enhanced treatment options.…”

Section: Discussionmentioning

confidence: 99%

Modulation of motor cortex excitability predicts antidepressant response to prefrontal cortex repetitive transcranial magnetic stimulation

2017

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Background Repetitive transcranial magnetic stimulation (RTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. Objective We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS. Methods Fifty-one medication-resistant MDD patients were enrolled for a 10-day treatment course of DLPFC rTMS and antidepressant response was assessed according to post-treatment reduction of the 17-item Hamilton Rating Scale for Depression score. Prior to treatment, we assessed the modulation of motor evoked potential (MEP) amplitude by MC rTMS. MEP’s were induced with single TMS pulses and measured using surface electromyography. MEP modulation was calculated as the change of mean MEP amplitude after MC rTMS. Results MEP modulation proved to be a robust predictor of reduction of clinician-rated depression severity following the course of DLPFC rTMS: larger MC rTMS-induced increase of corticospinal excitability anticipated a better antidepressant response. This was found both in univariate analyses (Spearman regression: rho=0.43, p<0.005) and a multivariable linear regression model (β=0.25, p<0.0001) controlling for baseline depression severity, age and resting motor threshold. Conclusions These findings suggest that MC rTMS-induced modulation of corticospinal excitability warrants further evaluation as a potential predictive biomarker of antidepressant response to left DLPFC 10 Hz rTMS.

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Section: Discussionmentioning

confidence: 99%

Modulation of motor cortex excitability predicts antidepressant response to prefrontal cortex repetitive transcranial magnetic stimulation

2017

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“…Since neural activity is tightly coupled to energy consumption, brain metabolic rate would provide a useful surrogate marker of brain activity. Unfortunately, the vast majority of PET studies of caffeine only measured relative but not absolute values of metabolic rate of glucose, due to the absence of arterial sampling data (Di et al, 2013; Park et al, 2014; Specterman et al, 2005). Thus, the effect of caffeine ingestion on absolute metabolic rate could not be addressed in those studies.…”

Section: Discussionmentioning

confidence: 99%

Does acute caffeine ingestion alter brain metabolism in young adults?

Liu

Pekar

et al. 2015

NeuroImage

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Caffeine, as the most commonly used stimulant drug, improves vigilance and, in some cases, cognition. However, the exact effect of caffeine on brain activity has not been fully elucidated. Because caffeine has a pronounced vascular effect which is independent of any neural effects, many hemodynamics-based methods such as fMRI cannot be readily applied without a proper calibration. The scope of the present work is two-fold. In Study 1, we used a recently developed MRI technique to examine the time-dependent changes in whole-brain cerebral metabolic rate of oxygen (CMRO2) following the ingestion of 200mg caffeine. It was found that, despite a pronounced decrease in CBF (p<0.001), global CMRO2 did not change significantly. Instead, the oxygen extraction fraction (OEF) was significantly elevated (p=0.002) to fully compensate for the reduced blood supply. Using the whole-brain finding as a reference, we aim to investigate whether there are any regional differences in the brain’s response to caffeine. Therefore, in Study 2, we examined regional heterogeneities in CBF changes following the same amount of caffeine ingestion. We found that posterior brain regions such as posterior cingulate cortex and superior temporal regions manifested a slower CBF reduction, whereas anterior brain regions including dorsolateral prefrontal cortex and medial frontal cortex showed a faster rate of decline. These findings have a few possible explanations. One is that caffeine may result in a region-dependent increase or decrease in brain activity, resulting in an unaltered average brain metabolic rate. The other is that caffeine’s effect on vasculature may be region-specific. Plausibility of these explanations is discussed in the context of spatial distribution of the adenosine receptors.

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“…Tiende ser una sustancia adictiva y por ende su disminución de ingesta o suspensión conlleva a un síndrome de abstinencia. [8] Glucosa: relacionado a la actividad neuronal ya que el cerebro para su metabolismo depende de los niveles de glucosa, esto en consecuencia señala que los cambios de concentraciones de glucosa en el organismo afectan la función neurológica. La glucosa además puede disminuir la fatiga periférica en el sistema muscular y circuitos de repetición.…”

Section: Componentes Principales De Las Bebidas Energéticasunclassified

Efectos de red bull en el organismo humano

Núñez¹,

Granados²,

Osorio³

et al. 2019

ESTR

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Las bebidas energizantes surgen por la necesidad de aumentar la energía y la concentración, aliviar la fatiga y mejorar condiciones cognitivas ante episodios de estrés, es por eso que nos enfocamos en los efectos que generan estas sustancias al organismo haciendo énfasis en la bebida “Red Bull”, siendo una de estas las más consumidas por la población y de origen más antiguo. Esta bebida contiene diferentes sustancias como cafeína, taurina, gluconorolactona entre otras, que actúan como estimuladoras del sistema nervioso llevando al individuo a un estado de alerta para poder realizar actividades

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The effect of an energy drink containing glucose and caffeine on human corticospinal excitability

Cited by 36 publications

References 19 publications

Modulation of motor cortex excitability predicts antidepressant response to prefrontal cortex repetitive transcranial magnetic stimulation

Modulation of motor cortex excitability predicts antidepressant response to prefrontal cortex repetitive transcranial magnetic stimulation

Does acute caffeine ingestion alter brain metabolism in young adults?

Efectos de red bull en el organismo humano

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