The Effect of an Intra-Uterine Suture on Fertility in the Rat

Abstract

A nylon suture inserted into one uterine horn prevented implantation in the same horn in 60\m=.\7% of rats. In the remainder which showed implantations in the treated horn, the number of implantation sites was significantly lower than in control horns. Some of these embryos were underdeveloped or dying.Histologically it could be shown that in some rats implantations occur even if the suture passes through the lumen of the horn.The leucocytic infiltration of the endometrium was associated with prevention of implantation, but it occurred, albeit to a lesser extent, also in rats with implantations in treated horns.

Hysteroscopic removal of unabsorbed suture material causing “unexplained” menstrual disorder

“…In our case unabsorbable suture material was discovered. Research has shown that, for example in rats, leucocystic infiltration was embedded in the uterine wall [4] after inserting nylon sutures into one of the uterine horns.…”

The Uterus and Control of Ovarian Function

“…As in rabbits, a silk suture placed in the uterine wall of rats will prevent implantation in that horn, but not in the contralateral one (Doyle & Margolis, 1963Havranek et al 1967). How- ever, presence of the IUD does not affect the number of ovulation points (Marston & Chang, 1964) or cause significant modification in uterine activity (Zembrana & Greenwald, 1969).…”