The effect of anabolic steroids on the biomechanical and histological properties of rat tendon.

Miles, Jon W.; Grana, William A.; Egle, D. M.; Min, Kyung-Whan; Chitwood, J.

doi:10.2106/00004623-199274030-00013

Cited by 90 publications

(89 citation statements)

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“…Experimental animal models have been used to investigate the effects of anabolic steroids in the presence of exercise on biomechanical properties of tendon [36,48]. These studies demonstrate anabolic steroid use during exercise produces a stiffer tendon which absorbs less energy and fails with less elongation.…”

Section: Effect Of Anabolic-androgenic Steroids On Tendon-bone Healingmentioning

confidence: 99%

Biological Augmentation of Rotator Cuff Tendon Repair

Kovacevic

Rodeo

2008

Clinical Orthopaedics &Amp; Related Research

227

181

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A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.

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Section: Effect Of Anabolic-androgenic Steroids On Tendon-bone Healingmentioning

confidence: 99%

Biological Augmentation of Rotator Cuff Tendon Repair

Kovacevic

Rodeo

2008

Clinical Orthopaedics &Amp; Related Research

227

181

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“…However, studies in rats demonstrated that AAS appear to induce changes in biomechanical properties of tendon. These may lead to a dysplasia of collagen fibrils, producing a stiffer and less elastic tendon [5,9]. Moreover, the combination of exercise and steroids potentiate the stiffness, decreasing the capacity of tendon elongation, leading to an increased risk of rupture.…”

Section: Discussionmentioning

confidence: 99%

“…Local injection of steroids is also associated to an increased risk of tendon rupture [2]. Furthermore, some authors correlated the systemic administration of fluoroquinolones [3], statins [4] and AAS [5,6] with tendon rupture.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Bilateral Patellar Tendon Rupture Associated with Anabolic Androgenic Steroids Use

Campos¹,

Rosa²,

Barros³

et al. 2017

Orthop Muscular Syst

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“…Miles et al [11] studied the dependence of anabolic steroid administration and efficiency training. They stated that steroids cause the formation of more rigid tendons, via increases in collagen fibre numbers and defective connections between them, which may lead to the weakening of the tendons and the increase in predisposition to tearing, even with smaller elongations.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of mechanical properties of animal tendons after corticosteroid therapy.

Olchowik

Siek²,

Tomaszewska³

et al. 2008

Folia Histochem Cytobiol.

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Abstract:The purpose of the study was to examine the effect of systemic glucocorticosteroids administration on mechanical properties of animal tendons. Twenty female Wistar rats were divided into two groups and those that formed experimental group were subjected activity of hydrocortisone given to the peritoneum. Mechanical tests were performed. Hydrocortisone administration caused reduction of force value and the increase of strain, also the value of elasticity module was significantly smaller comparing to the control group. The results of biomechanical tests suggested that glucocorticoids produce less stiffness tendon, which fails in maximum point of load. This study revealed that systemic hydrocortisone administration changes significantly mechanical properties of tendons, which may cause frequent failure of the tendon.

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The effect of anabolic steroids on the biomechanical and histological properties of rat tendon.

Cited by 90 publications

References 0 publications

Biological Augmentation of Rotator Cuff Tendon Repair

Biological Augmentation of Rotator Cuff Tendon Repair

A Rare Case of Bilateral Patellar Tendon Rupture Associated with Anabolic Androgenic Steroids Use

The evaluation of mechanical properties of animal tendons after corticosteroid therapy.

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