The Effect of Anaesthetic Agents on Primary Cortical Evoked Responses

Angel, A.; Berridge, D.Denise A.; Unwin, J

doi:10.1093/bja/45.8.824

Cited by 45 publications

(35 citation statements)

References 10 publications

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“…This discrepancy seems to be partly due to the differences in the depth of electrodes (7). In addition, an anesthetic influences the SEP (8,9). Since the recovery function is determined by the number of synapses between the stimulus site and the generator of the potential (10), SEP recovery functions are also influenced by anesthesia (1 1, 12).…”

Section: Discussionmentioning

confidence: 99%

Somatosensory evoked potentials in rats with hypocalcemia.

et al. 1989

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The effects of hypocalcemia on somatosensory evoked potentials (SEPs) were studied in rats. The SEP in awake rats consisted of an unstable, large, negative wave (Nmax) preceded by a small positive one (PI). The PI appeared to be a subcortical potential and Nmaxappeared to represent the function of the cerebral cortex. With the decrease in calcium concentration caused by parathyroidectomy, as well as by administration of EDTA, an augmentation of amplitudes of the Nmaxand a reduction in the SEPrecovery functions were observed. The latency of PI was hardly changed. The decrease in the SEP recovery functions possibly reflects a reduction in synaptic efficiency, and the increasing amplitude of the SEPprobably reflects the cortical hyperexcitability caused by hypocalcemia.

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Section: Discussionmentioning

confidence: 99%

Somatosensory evoked potentials in rats with hypocalcemia.

et al. 1989

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“…In one animal the left side was occluded first and the same left-to right flow difference was found. It seems more likely that the difference was due to the position of the flow electrodes, anterior to the bregma on the right side [in the somatosensory cortical area (Angel et a!., 1973)] and posterior to the Bregma on the left side. The posterior position probably receives more collateral circulation from the basilar artery terri tory.…”

Section: Blood Flowmentioning

confidence: 99%

Extracellular pH, Potassium, and Calcium Activities in Progressive Ischaemia of Rat Cortex

Harris

Symon

1984

J Cereb Blood Flow Metab

170

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Summary:We measured the relationships between changes in extracellular pH (pHe)' potassium (Ke), and calcium (Cae) activities and DC potential (DCe) in pro gressive ischaemia of rat cerebral cortex, pHe and Ke, or Cae and Ke, were measured at the same point simulta neously, using triple-barrelled, double-ion-sensitive mi croelectrodes. Ischaemia was produced using bilateral ca rotid artery occlusion and hypotension in rats under 50% N 2 0-0.4% halothane anaesthesia. Unilateral carotid ar tery occlusion did not affect blood flow, but bilateral oc clusion reduced flow to �40% of normal. Autoregulation of blood pressure (BP) changes was lost after bilateral occlusion, and so progressive hypotension produced a linear decrease in flow. pHe began to decrease at high

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“…a dose that prevents visible reflex responses to surgery). The animal then underwent a tracheal cannulation, a mid-line skin incision over the cranium, opening of the foramen magnum (to prevent cerebral oedema see Angel, Berridge & Unwin 1973), and an extensive craniotomy to expose the left cerebral hemisphere from which the dura mater was reflected. The animals were then mounted in a stereotaxic frame and a pool constructed over the cerebral cortex by gripping the cut skin edges between an inner perspex ring and an outer metal clip.…”

Section: Acute Experimentsmentioning

confidence: 99%

The Effect of Anaesthetic Agents on Cerebral Cortical Responses in the Rat

Angel

Gratton

1982

British J Pharmacology

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1 In rats, surgically anaesthetized with Urethane, an increase in the depth of anaesthesia upon administration of ethyl carbamate (Urethane), pentobarbitone sodium (Nembutal), thiopentone sodium (Intraval), althesin, ketamine, trichloroethylene, halothane, methoxyflurane, diethyl ether, ethyl-vinyl ether, cyclopropane, enflurane or chloroform resulted in a dose-dependent increase in the latency, and decrease in the amplitudes of the initial positive and negative components of the short latency cortical response to electrical stimuli applied to the forepaw. 2 The same changes were seen when starting from initially unanaesthetized rats and anaesthetizing them with Urethane. 3 With all the inhalational agents used these changes lasted for as long as the administration except with nitrous oxide where the changes in the cortical response were transient.4 The tranquillizing agents diazepam, chlordiazepoxide, and haloperidol showed no such action. Chloral hydrate and chlorpromazine, on the other hand, produced moderate changes in the evoked cortical response similar to those seen with the other anaesthetic agents used.

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The Effect of Anaesthetic Agents on Primary Cortical Evoked Responses

Cited by 45 publications

References 10 publications

Somatosensory evoked potentials in rats with hypocalcemia.

Somatosensory evoked potentials in rats with hypocalcemia.

Extracellular pH, Potassium, and Calcium Activities in Progressive Ischaemia of Rat Cortex

The Effect of Anaesthetic Agents on Cerebral Cortical Responses in the Rat

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