2022
DOI: 10.1590/s2175-97902022e21010
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The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats

Abstract: Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor antagonist used in rheumatoid arthritis treatment. This study investigated the effect of anakinra on acrylamide-related neuropathy and neuropathic pain. Acrylamide exposure caused a significant decrease in the pain threshold; an increase in malondialdehyde (MDA), tumor necrosis factoralpha (TNF-α), and interleukin-1 beta (IL-1β) levels; and a decrease in total glutathione (tGSH) values in the sciatic nerve. This indicat… Show more

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“…Additionally, acrylamide exposure has been associated with an increase in the degeneration of noradrenergic axons in the cortex and prefrontal cortex (PFC) regions of the mouse brain (Davuljigari et al, 2021;Ekuban et al, 2021). According to a recent study by Ersoy et al (2022), intraperitoneal administration with Anakinra at 50 mg/kg body weight has been shown to reduce neuropathic pain and prevent the neurotoxic effects of acrylamide on peripheral nerves. This is believed to be due to the analgesic, antioxidant, and anti-inflammatory properties of Anakinra.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, acrylamide exposure has been associated with an increase in the degeneration of noradrenergic axons in the cortex and prefrontal cortex (PFC) regions of the mouse brain (Davuljigari et al, 2021;Ekuban et al, 2021). According to a recent study by Ersoy et al (2022), intraperitoneal administration with Anakinra at 50 mg/kg body weight has been shown to reduce neuropathic pain and prevent the neurotoxic effects of acrylamide on peripheral nerves. This is believed to be due to the analgesic, antioxidant, and anti-inflammatory properties of Anakinra.…”
Section: Discussionmentioning
confidence: 99%