The effect of analogues of angiotensin II on drinking and cardiovascular responses to central angiotensin II in the rat.

Abstract

SUMMARY1. Intracerebroventricular (i.c.v.) infusion (60 ng h-1) of Isoleu5-angiotensin II (Isoleu5-AngIl) and des-amine-angiotensin II (des-amine-AngII) in rats caused increased drinking behaviour and an increase in arterial blood pressure.2. Des-amine-AnglI caused similar increases in heart rate and arterial blood pressure as AnglI. 4. The three antagonists had no effect on the increase in arterial blood pressure and heart rate caused by des-amine-AngII. The drinking response was reduced by previous injection of [Leu8]-Angll and des-amine-[Leu8]-Angll but not by octanoyl-[Leu8]-AngII.5. In conclusion, Isoleu5-AngII and des-amine-Angll increase drinking behaviour, arterial blood pressure and heart rate when infused into the cerebral ventricle of rats. The study with the antagonists showed that des-amine-AnglI probably binds more strongly to AnglI-receptors.