The Effect of Anemia on Retinopathy of Prematurity in Extremely Low Birth Weight Infants

Englert, Judith A.; Saunders, Richard; Purohit, Dilip M.; Hulsey, Thomas C.; Ebeling, Myla

doi:10.1038/sj.jp.7200511

Cited by 58 publications

(62 citation statements)

References 16 publications

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“…2,3 The strong associations reported between neonatal diagnoses or therapies and subsequent ROP suggest that severe illness, or an unstable fluctuating hospital course in general, are associated with risk for developing severe ROP. [4][5][6][7][8][9][10][11][12][13][14] Standardized illness severity (IS) measurements are widely used to account for variations in neonatal outcomes among hospitals. 15 The Score for Neonatal Acute Physiology (SNAP score) 16 on the first day of life appears associated with development of any ROP 17 and severe ROP.…”

Section: Introductionmentioning

confidence: 99%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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Objective: To test cumulative neonatal illness severity (IS) and IS fluctuation as predictors of progression from moderate to severe retinopathy of prematurity (ROP).Study Design: Data from research databases and medical record review were collected for infants from four neonatal intensive care unit (NICUs) admitted between 1995 and 2001 and diagnosed with prethreshold ROP. Cumulative neonatal IS measured using daily Scores for Neonatal Acute Physiology (SNAP) for the first 28 days of life, and IS fluctuation as assessed by summing changes between daily SNAP scores, were tested as predictors of progression to threshold ROP using logistic regression.Result: Infants progressing to threshold (n ¼ 79), compared to those not progressing to threshold (n ¼ 130), had significantly (P<0.05) lower gestational ages (25.2±1.1 versus 25.8±1.4 weeks), higher cumulative neonatal SNAP (255±77 versus 224±63 weeks) and had more severe hospitalizations as indicated by diagnoses and medical management. In regression analysis, gestational age, chronological age and presence of plus disease at first diagnosis of prethreshold were associated with development of threshold. After adjusting for these factors, cumulative neonatal SNAP was significantly associated with progression to threshold. However, addition of cumulative SNAP to the model only increased receiver-operating characteristic curve area from 0.77 to 0.78 (NS). Other factors, including SNAP fluctuation, were not associated with progression to threshold after adjustment using this model. Conclusion:Cumulative neonatal IS, as measured by cumulative SNAP, is an independent risk factor for progression from moderate to severe ROP. However, cumulative IS does not enhance assessment of risk for ROP progression after adjusting for simpler clinical factors.

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Section: Introductionmentioning

confidence: 99%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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“…A retinopatia da prematuridade (ROP) é uma doença vasoproliferativa da retina, de etiologia multifatorial (1) , relacionada principalmente à prematuridade, oxigenioterapia prolongada (1)(2) e ao baixo peso ao nascer. Além desses, podemos citar outros fatores de risco, tais como: gemelaridade, sepse, transfusão sanguínea, hemorragia intraventricular, fototerapia, apnéia e anemia (1)(2) .…”

Section: Resumo Introduçãounclassified

“…Além desses, podemos citar outros fatores de risco, tais como: gemelaridade, sepse, transfusão sanguínea, hemorragia intraventricular, fototerapia, apnéia e anemia (1)(2) .…”

Section: Resumo Introduçãounclassified

Incidência e fatores de risco da retinopatia da prematuridade no Hospital Universitário Onofre Lopes, Natal (RN) - Brasil

Pinheiro¹,

Silva

Bessa

et al. 2009

Arq. Bras. Oftalmol.

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20 dias (p=0,022; ORaj=3,40; IC= 1,19-9,69) e a transfusão sanguínea (p=0,022; ORaj=2,06; IC= 1,11-3,83) são fatores independentes de risco para a doença. CONCLUSÕES: O estudo demonstra uma alta incidência da patologia no serviço. O baixo peso ao nascer, um tempo prolongado de oxigenoterapia, bem como a transfusão sanguínea são fatores associados ao desenvolvimento da retinopatia da prematuridade. Idade gestacional não é um dado confiável para a triagem dos neonatos realizada pelo setor.]]>

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“…The complications and potential risk of blood transfusions include blood -transmitted infection, metabolic and cardiovascular complications, graft versus host disease, iron overload and increased oxidative stress, which are thought to be related to complications in premature infants such as chronic lung disease (CLD) and retinopathy of prematurity (ROP) (Cooke et al ,1997;Saugstad ,2003;Englert et al ,2001;Wheatley et al ,2002)considering the available evidence, many neonatal units have adopted more restrictive transfusion guidelines to reduce the frequency of transfusions and donor exposure (Windes et al, 1996;Alagappan& Shattuck& Malloy,1998;Maier et al, 2000;)But, these changes in practice have not been accompanied by systematic examination of the safety or potential benefits of restricting transfusions. Limiting RBC transfusion in preterm infants may reduce the potential risk of transfusion, but the resulting low hemoglobin levels may result in the morbidities associated with chronic anemic hypoxemia as recommended by some studies that advocate more than liberal transfusion guidelines to prevent apnea (Ross et al, 1989), to foster weight gain (Meyer & sive & Jacobs, 1993).…”

Section: Blood Transfusion In Preterm Infantsmentioning

confidence: 99%

Effects of Blood Transfusion on Retinopathy of Prematurity

Mikaniki¹,

Mikaniki²,

Shirzadian³

2012

Blood Transfusion in Clinical Practice

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The Effect of Anemia on Retinopathy of Prematurity in Extremely Low Birth Weight Infants

Cited by 58 publications

References 16 publications

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Incidência e fatores de risco da retinopatia da prematuridade no Hospital Universitário Onofre Lopes, Natal (RN) - Brasil

Effects of Blood Transfusion on Retinopathy of Prematurity

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