The effect of anesthesia on acquisition and extinction of conditioned taste aversion

Burešová, O.; Bureš, Jan

doi:10.1016/s0091-6773(77)90473-4

Cited by 56 publications

(35 citation statements)

References 8 publications

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Section: Introductionsupporting

confidence: 94%

“…1A); DW: 13.2 ± 1.1 ml, D1: 1.8 ± 0.2 ml (p < 0.001), D2: 4.2 ± 1.0 ml (p < 0.01), D3: 8.4 ± 0.9 ml (p < 0.05), n = 5, for saline injection. These results are consistent with those of previous reports [6,32].On the other hand, when subhypnotic doses of midazolam were administrated after exposure to CS, the extinction was greatly accelerated and the amount of Sac intake greatly increased on the 2nd and 3rd test days. When i.p.…”

supporting

confidence: 93%

“…However, the -6 -amount of Sac intakes gradually increased toward the 3rd test day (D3: 5.9 ± 1.5 ml) as shown in previously reports [3,5,6,10,15,33]. When CS was paired with saline instead of LiCl, CTA was never induced, and rather significant increase of Sac intake was observed on the 2nd to 3rd test day rather than decreaseas shown in our previous paper [15].…”

Section: Introductionsupporting

confidence: 83%

“…The association between the CS and the US can proceed under deep anesthesia induced by pentobarbital or ketamine when hypnotic doses of these anesthetics are administrated after CS-presentation, or subhypnotic doses of them, which do not impair drinking, was applied before CS-presentation [6,33].…”

Section: Introductionmentioning

confidence: 99%

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Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats

Ayuse

Yoshida

et al. 2009

Neuroscience Letters

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Some intravenous anesthetic agents such as midazolam are known to induce anterograde and retrograde amnesia. We analysed the effect of midazolam by the conditioned taste aversion (CTA) acquisition and retention. After the rats were offered 0.1% sodium saccharin (Sac) as conditioned stimulus (CS), an intraperitoneal (i.p.) injection of several concentrations (5 ~ 30 mg/kg) of midazolam was followed by an i.p. injection of 0.15 M LiCl (2% of body weight) as unconditioned stimulus (US). The rats, which acquired CTA by every CS-US paradigm, strongly avoided Sac on the 1st test day after conditioning and maintained the avoidance for 3 days. We have already reported that Sac intake abruptly increased on the 2nd test day and the almost complete extinction occurred on the 3rd test day after conditioning by injection of subhypnotic dose of propofol before LiCl-injection. In contrast, we found that subhypnotic dose of midazolam suppressed not only CTA acquisition, but also CTA retention. On the other hand, an α2-adrenergic blocker, yohimbin (1 mg/kg) suppressed only the CTA retention. These results suggest that the subhypnotic doses of midazolam firstly affect the acquisition mechanism of the CTA memory (CTAM ), resulting the suppression of the retention of CTAM.Key words: midazolam ; CTA; memory; acquisition; extinction; amnesia, Yohimbin, noradrenergic system -3 -Intravenous anesthetics such as midazolam, one of benzodiazepine anesthetic agents, which possess both γ-aminobutylic acid (GABA)-like [13,29], are known to induce anterograde and retrograde amnesia in human [16,17] and rodents [24,26]. In rodents, it has been reported that anterograde amnesia of an avoidance task was elicited by subhypnotic doses of the intravenous anesthetics, but retrograde amnesia was induced merely by hypnotic doses of these anesthetics [24,25,27].Previous works using a CTA paradigm, where conditioned taste aversion memory (CTAM) related to malaise is formed when an animal consumes a novel taste such as saccharin (conditioned stimulus, CS) and then experiences the symptoms of poisoning such as LiCl (unconditioned stimulus, US) [9], show that the strong CTA is established rapidly by novel taste stimuli in a single learning procedure [5,32]. The association between the CS and the US can proceed under deep anesthesia induced by pentobarbital or ketamine when hypnotic doses of these anesthetics are administrated after CS-presentation, or subhypnotic doses of them, which do not impair drinking, was applied before CS-presentation [6,33].However, subhypnotic doses of the intravenous anesthetics are often used for disabled patients even in light operation such as extraction of teeth to sedate their hyperactivity [22,31]. We often encounter patients, who have lost the memory during operation after administration of sedative dose of these intravenous anesthetics while they preserved their consciousness during operation [22]. In the previous paper [15], we reported that subhypnotic but not hypnotic doses of propofol, one of non-benzodiazepine...

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Section: Introductionsupporting

confidence: 94%

supporting

confidence: 93%

Section: Introductionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats

Ayuse

Yoshida

et al. 2009

Neuroscience Letters

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“…We are satisfied by B. M. Rabin and J. S. Rabin's (1986) statement that there is no controversy between the papers by Buresova and Bures (1977) and Rabin and Rabin (1984), but we cannot agree with their argument that additional procedural information provided in our note (Buresova & Bures, 1986) was needed to arrive at this conclusion. Our 1977 paper made it clear that "deep allobarbital anesthesia ... was maintained throughout the 5-h CS-US interval" (p. 43).…”

mentioning

confidence: 60%

Conditioned taste aversion in anesthetized rats: A comment on Rabin and Rabin’s reply

Burešsová

Bureš

1986

Animal Learning & Behavior

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Conditioned taste aversion induced in rats by intracerebral or systemic administration of monoamine oxidase inhibitors

Burešová

Bureš

1987

Psychopharmacology

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Conditioned taste aversion (CTA) elicited by systemic or intracerebral application of the monoamine oxidase inhibitors clorgyline (C), pargyline (P) or deprenyl (D) was studied in 402 rats. Water-deprived animals were allowed 15 min access to 0.1% sodium saccharin (CS) followed 10 min later by IP or by intracerebral injection of the drug. In the latter case, the animals were anesthetized 5 min after saccharin drinking with pentobarbital and the drug was stereotaxically injected (1 microliter/min, 1-2 microliters) into the target structure. CTA was assessed in a two-choice retention test performed 2 days later. A geometric progression of three to six dosages applied to groups of rats (n = 10) was employed to establish the effective doses of the drugs which were 4, 20 and 32 mg/kg with IP and 2.5, 10 and 80 micrograms per rat with intracerebral (n. raphé magnus) injections of C, P, and D, respectively. The ratios of intracerebral to systemic dosages eliciting comparable CTA were 1:300 for C, 1:800 for P and 1:100 for D. Injections of 2.5 micrograms C and 10 micrograms P into the mesencephalic reticular formation, medial hypothalamus and cerebral cortex were ineffective, as were injections of 10 micrograms P into the nucleus of the solitary tract and cerebellum. The results indicate that CTA is elicited more efficiently by inhibition of monoamine oxidase A (selectively inhibited by C) than of monoamine oxidase B (selectively inhibited by D).

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The effect of anesthesia on acquisition and extinction of conditioned taste aversion

Cited by 56 publications

References 8 publications

Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats

Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats

Conditioned taste aversion in anesthetized rats: A comment on Rabin and Rabin’s reply

Conditioned taste aversion induced in rats by intracerebral or systemic administration of monoamine oxidase inhibitors

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