The Effect of Angiogenesis-Based Scaffold of MesoporousBioactive Glass Nanofiber on Osteogenesis

Zheng, Weijia; Bai, Zhenzu; Huang, Shan; Jiang, Kai; Liu, Long; Wang, Xiaoyan

doi:10.3390/ijms232012670

Cited by 9 publications

(1 citation statement)

References 72 publications

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“…In recent decades, the rapid advancement of nanotechnology and study of new excipients has led to significant improvements in the bioavailability of drugs, while simultaneously promoting safe, effective, and convenient drug delivery systems [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Hence, many newly proven safe and biocompatible excipients have been introduced, such as PVA, PVP, PEO, PCL, gelatin, etc.…”

Section: Introductionmentioning

confidence: 99%

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Zhou,

Wang,

Gong

et al. 2023

Biomedicines

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In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were applied to the development of a new type of pharmaceutical formulation, aiming to achieve rapid hemostasis, pain relief, and antimicrobial properties. Briefly, an approach combining a electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent was employed to fabricate a novel beaded nanofiber structure (BNS), consisting of micrometer-sized particles distributed on a nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) particles were prepared using the solution electrospraying process. Subsequently, these particles were suspended in a co-solvent solution containing ciprofloxacin (CIP) and hydrophilic polymer polyvinylpyrrolidone (PVP) and electrospun into hybrid structural microfibers using a handheld electrospinning device, forming the EHDA product E3. The fiber-beaded composite morphology of E3 was confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis revealed the amorphous state of CIP in the BNS membrane due to the good compatibility between CIP and PVP. The rapid dissolution experiment revealed that E3 exhibits fast disintegration properties and promotes the dissolution of CIP. Moreover, in vitro drug release study demonstrated the complete release of CIP within 1 min. Antibacterial assays showed a significant reduction in the number of adhered bacteria on the BNS, indicating excellent antibacterial performance. Compared with the traditional YB powders consisting of Chinese herbs, the BNS showed a series of advantages for potential wound dressing. These advantages include an improved antibacterial effect, a sustained release of active ingredients from YB, and a convenient wound covering application, which were resulted from the integration of Chinese herbs and Western medicine. This study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines from the combination of herbal medicines and Western medicines.

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Section: Introductionmentioning

confidence: 99%

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Zhou,

Wang,

Gong

et al. 2023

Biomedicines

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Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

et al. 2023

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Electrospinning is a promising approach for the development of fibrous tissue engineering (TE) scaffolds suitable for hard and soft tissues. Apart from physicomechanical properties, electrospun fibers are required to incorporate bioactive cues to control cellular functions, including facilitating biomineralization and osteogenic differentiation in case of bone TE, as well as vascularization, to support successful tissue regeneration. In recent years, bioactive glass (BG) addition to electrospun biopolymer fibers has shown promising results in enhancing the properties of fibers, including the improvement of biological performance. In this article, a comprehensive overview of BG‐containing electrospun polymer composite fibers is presented, identifying the parameters that affect the mechanical properties as well as the biological response in vivo and in vitro. Subsequently, the effects of BG addition on the properties of the scaffolds are discussed. Recent developments in the fields of bone regeneration, wound healing, and drug delivery using BG‐containing electrospun fibrous scaffolds are described in detail. Essential aspects related to BG‐polymer composite fibers for translational research in TE are highlighted for future research in this field.

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Strategies in Electrospun Polymer and Hybrid Scaffolds for Enhanced Cell Integration and Vascularization for Bone Tissue Engineering and Organoids

Polak,

Karbowniczek,

Stachewicz

2024

WIREs Nanomed Nanobiotechnol

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Addressing the demand for bone substitutes, tissue engineering responds to the high prevalence of orthopedic surgeries worldwide and the limitations of conventional tissue reconstruction techniques. Materials, cells, and growth factors constitute the core elements in bone tissue engineering, influencing cellular behavior crucial for regenerative treatments. Scaffold design, including architectural features and porosity, significantly impacts cellular penetration, proliferation, differentiation, and vascularization. This review discusses the hierarchical structure of bone and the process of neovascularization in the context of biofabrication of scaffolds. We focus on the role of electrospinning and its modifications in scaffold fabrication to improve scaffold properties to enhance further tissue regeneration, for example, by boosting oxygen and nutrient delivery. We highlight how scaffold design impacts osteogenesis and the overall success of regenerative treatments by mimicking the extracellular matrix (ECM). Additionally, we explore the emerging field of bone organoids—self‐assembled, three‐dimensional (3D) structures derived from stem cells that replicate native bone tissue's architecture and functionality. While bone organoids hold immense potential for modeling bone diseases and facilitating regenerative treatments, their main limitation remains insufficient vascularization. Hence, we evaluate innovative strategies for pre‐vascularization and discuss the latest techniques for assessing and improving vascularization in both scaffolds and organoids presenting the most commonly used cell lines and biological models. Moreover, we analyze cutting‐edge techniques for assessing vascularization, evaluating their advantages and drawbacks to propose complex solutions. Finally, by integrating these approaches, we aim to advance the development of bioactive materials that promote successful bone regeneration.

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The Effect of Angiogenesis-Based Scaffold of MesoporousBioactive Glass Nanofiber on Osteogenesis

Cited by 9 publications

References 72 publications

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

Strategies in Electrospun Polymer and Hybrid Scaffolds for Enhanced Cell Integration and Vascularization for Bone Tissue Engineering and Organoids

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