The effect of ankaferd blood stopper on epidural fibrosis after laminectomy in rats: an experimental study

Yılmaz, Murat; Gülabi, Deniz; Güçlü, Bülent; Kaya, İbrahim; Kayhan, Basak; Baş, Ali

doi:10.5137/1019-5149.jtn.14559-15.1

Turkish Neurosurgery

2015

DOI: 10.5137/1019-5149.jtn.14559-15.1

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The effect of ankaferd blood stopper on epidural fibrosis after laminectomy in rats: an experimental study

Murat Yılmaz

Deniz Gülabi²,

Bülent Güçlü³

et al.

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2022

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“…Yilmaz et al showed that the epidural fibrosis of ABS increased in the rat laminectomy model(22). Erdoğan et al compared the efficacy of Microporous Polysaccharide Hemospheres (MPH) and ABS on epidural fibrosis in a laminectomy model in rats.…”

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confidence: 99%

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

Egemen

Dere

Koluman

et al. 2022

Batı Karadeniz Tıp Dergisi

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Aim: Haemostasis is a vital stage for the success of the surgery. Although Ankaferd Blood Stopper (ABS), a low-cost and reliable agent, is used in many surgeries, it is not yet available for use in the intracranial area. This study aims to reveal ABS’s cytotoxic effects and safety profile in mammalian brain parenchyma. Material and Methods: 30 Wistar Albino rats were divided into three groups consisting of 10 rats. Haemostasis was achieved with saline in group 1, 50% diluted ABS in group 2, and 100% ABS in group 3 in bleeding caused by damage to the brain parenchyma. Urotensin, Antithrombin III (AT3) and fibrinogen were studied in blood samples taken before surgery and during sacrification. In addition, the histologic examination was performed after the sacrification of rats and injury scores were assessed. Results: Fibrinogen levels in groups 2 and 3 were significantly higher than group 1 in blood samples taken before surgery. There was a significant increase in urotensin during sacrification compared to the pre-surgical period in all three groups. (p=0.005) Slight injury in group 2, mild injury in group 3, and severe injury in group 1 were statistically significantly higher. (p=0.005) These results indicate that the use of 50% diluted ABS is safe. Conclusion: ABS, used for the first time in the mammalian brain parenchyma, was evaluated as safe in rats. Compared to haemostatic matrix agents, in addition to safety and efficacy, its low cost might increase its clinical use in the future.

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confidence: 99%

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

Egemen

Dere

Koluman

et al. 2022

Batı Karadeniz Tıp Dergisi

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The effect of ankaferd blood stopper on epidural fibrosis after laminectomy in rats: an experimental study

Cited by 1 publication

References 26 publications

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

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