The effect of anti-tuberculosis chemotherapy on vitamin D and calcium metabolism

Atorvastatin Increases 25-Hydroxy Vitamin D Concentrations in Patients with Polycystic Ovary Syndrome

“…Statins have been shown to have a beneficial effect in reducing infective or inflammatory episodes (41 ), in a pattern similar to that of 25OHD (14 ). It has been observed that blood 25OHD concentrations are low in patients with tuberculosis and remain low throughout treatment but increase afterward spontaneously (42 ). Hypothetically, statins may suppress the inflammatory processes that would consume vitamin D, leading to its serum increase.…”

Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London

“…Anti-TB chemotherapy has been hypothesised to modestly reduce vitamin D levels. 31,32 In our study, 25(OH)D 3 assays were mainly performed on our patients at commencement of TB therapy. Plasma 25(OH)D 3 levels obtained in 101 patients more than a week after commencement of anti-TB therapy demonstrated no statistically significant differences from those obtained prior to, or at commencement of, therapy (data not shown).…”

Chalk and cheese: symptomatic hypocalcaemia during paediatric anti-tuberculous therapy

“…16 In healthy adults both drugs cause levels of both vitamin D 2 and D 3 to fall significantly, with a concomitant increase in PTH. 14,17 The mechanism appears to be through the effect of both isoniazid and rifampicin on vitamin D metabolism. 18,19 Isoniazid disrupts hepatic vitamin D 25-hydroxylase and possibly also renal 1a-hydroxylase.…”