The effect of antiaggregating drugs on the patency of grafts in the arterial system

Abstract

In experiments in dogs we studied the effect of antiaggregating agents on the patency of prosthetic vascular grafts (4 mm in diameter) and vein grafts, both placed in areas with a rate of flow ranging between 50-60 ml/min. All 6 prosthetic grafts became occluded in the nonmedicated controls, 1 of 5 prosthetic grafts remained patent for a prolonged period of time in dogs receiving 250 mg acetylsalicylic acid 3 times a day, while 5 of 6 prosthetic grafts remained patent in animals receiving an antiaggregating mixture. Follow-up studies showed that antiaggregating medication had no effect on the patency of vein grafts, but it prevented the formation of mural thrombi and subendothelial proliferation.

Meta-Analysis of Multi-Arm Trials Using Empirical Logistic Transform

“…Clinically, after coronary artery revascularisation of patients, whether by coronary artery bypass grafting or by percutaneous transluminal coronary angioplasty, angiographic studies show substantial rates of re-occlusion [9]. Experimental and clinical evidence suggests that antiplatelet therapy may help prevent vascular graft or arterial occlusions, particularly during the period soon after vascular procedures, before any intimal damage has healed [10, 11]. The data was analyzed in order to determine the efficacy of antiplatelet therapy in maintaining vascular patency.…”