The effect of anticonvulsant use on bone mineral density in non-ambulatory children with cerebral palsy

Cheng, SW; Ko, CH; Cy, Lee

doi:10.12809/hkmj154588

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…There is conflicting evidence for the role of anticonvulsive drugs as a risk factor for low BMD. In a study of non-ambulatory children with CP, no significant differences in BMD were found between children taking and not taking anticonvulsant therapies (Cheng et al, 2016). However, nutritional status was implicated as a risk factor.…”

Section: Cerebral Palsymentioning

confidence: 90%

Effects of Neurological Disorders on Bone Health

2020

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Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.

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Section: Cerebral Palsymentioning

confidence: 90%

Effects of Neurological Disorders on Bone Health

2020

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“…The effects of phenobarbital, carbamazepine, and phenytoin are correlated with bone mineral density (BMD) reduction related to cytochrome P450 (CYP450) induction, resulting in vitamin D reduction, hyperparathyroidism, increased bone remodeling, and consequent BMD reduction. Although sodium valproate is a CYP450 inhibitor, this AED also promotes BMD reduction [6,7].…”

Section: Introductionmentioning

confidence: 99%

Mandible bone density in adolescents with cerebral palsy using antiepileptic drugs

et al. 2022

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Objective:The aim of this study was to assess the bone density of the mandible in adolescents with cerebral palsy (CP) treated with antiepileptic drugs using one beam computed tomography (CBCT). Methods: The study was carried out with 18 adolescents aged 12-18 years, undergoing routine dental treatment at the dental clinic of APCD-São Caetano do Sul. CBCT scans were of divided into two groups: G1 adolescents with CP using antiepileptic drugs and G2 normoactive adolescents. A single dentomaxillofacial radiologist assessed and evaluated the images using Dental Slice software and Image J. Fisher's exact tests as well as paired and unpaired Student's t-tests were performed. Results: Groups differed significantly with regard in the values of density (p < 0.001), with G1 presenting lower values compare to G2. G1 showed significantly lower density means on the right side, left side, and right/left sides of the mandible edge than G2 (p < 0.001). Conclusion: CP patients using antiepileptic drugs show evidence of bone mineral density loss of the mandible.

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Assessment of nutritional status and bone health in neurologically impaired children: a challenge in pediatric clinical practice

Crehuá-Gaudiza

García-Peris

Calderón³

et al. 2019

Nutr Hosp

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I, López Pedrosa JM. Infl uencia del suplemento con inulina enriquecida con fructooligosacáridos sobre el contenido y la densidad mineral ósea tras el parto y la lactación en ratas. AbstractIntroduction: Pregnancy and lactation are related with temporary decreases in maternal bone mineral density (BMD). Calcium supplementation could be benefi cial to prevent bone loss of maternal skeleton. Other nutrients, such as prebiotics have showed to produce an increase of the mineral absorption and therefore affecting bone mineralization. Objective: To study the effect of maternal diet supplementation with prebiotic oligofructose-enriched inulin during gestation and lactation on the maternal bone mineral content (BMC) and BMD at the end of lactation. Methods: Pregnant rats were fed with standard diet (CC group), calcium fortifi ed diet (Ca group) or with prebiotic oligofructose-enriched inulin supplemented diet until the end of the lactation period. At weaning, bone mineral content (BMC) and BMD were determined by dual-energy X-ray absorptiometry and the pH of the cecal content was also determined. Results: In absolute terms, the highest BMD and BMC were found in the Pre group as compared with the other two groups being signifi cant in the tibia when compared Pre group and CC group with Ca group. The pH of the cecal content in the Pre group was also signifi cantly lower as compared with the other two groups. Conclusion: Prebiotic oligofructose-enriched inulin supplementation, in calcium no-defi cient conditions, during gestation and lactation exerts a protection on maternal skeleton during pregnancy and lactation in the rats and could be considered as a plausible nutritional option for protecting maternal bone mass during these periods.

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The effect of anticonvulsant use on bone mineral density in non-ambulatory children with cerebral palsy

Cited by 4 publications

References 21 publications

Effects of Neurological Disorders on Bone Health

Effects of Neurological Disorders on Bone Health

Mandible bone density in adolescents with cerebral palsy using antiepileptic drugs

Assessment of nutritional status and bone health in neurologically impaired children: a challenge in pediatric clinical practice

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