The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats

Szymańska, Magdalena; Budziszewska, Bogusława; Jaworska-Feil, L; Basta‐Kaim, Agnieszka; Kubera, Marta; Leśkiewicz, Monika; Regulska, Magdalena; Lasoń, Władysław

doi:10.1016/j.psyneuen.2008.12.012

Cited by 105 publications

(69 citation statements)

References 46 publications

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“…In agreement with previous data [8,25,28,32], the prenatally stressed rats were found to exhibit significantly greater levels of immobility behavior and reduced climbing time in the forced swimming test compared to the control animals, i.e. these rats exhibited depression-like behavior (fig.…”

Section: Resultssupporting

confidence: 92%

“…Based on the existing data, it seems that prenatal stress may increase the sensitivity of brain tissue to adverse factors that act during adulthood rather than evoking changes in basal conditions. In the present study, we applied a prenatal stress model of depression because we have previously demonstrated hyperactivity of the HPA axis and increases in glucocorticoid receptor function using this model [25]. Moreover, the face, predictive and construct validities of this model have previously been characterized.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

et al. 2014

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Introduction: Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations in the hippocampus and frontal cortex in a prenatal stress rat model of depression. Methods: Male rats whose mothers had been subjected to stress and control animals were subjected to the Porsolt test to verify the experimental model. Next, some of the rats were subjected to acute stress and/or were administered glucose. Glucose, glycogen, corticosterone, insulin, insulin receptor, phospho-insulin receptor and glucose transporter (GLUT1, GLUT3 and GLUT4) concentrations were assayed. Results: Prenatally stressed rats exhibited glucose and glycogen concentrations in both investigated brain structures that exceeded those of the control animals. Prenatal stress also increased the levels of glucose transporters - GLUT1 in both tissues and GLUT4 in the frontal cortex. The changes in the prenatally stressed rats were more prominent in the animals that were subjected to stress or glucose loading in adulthood. Conclusion: The increase in carbohydrate brain concentrations evoked by prenatal stress may result from changes in the amounts of glucose transporters, especially GLUT1. Moreover, the obtained results support the hypothesis that stress during the perinatal period permanently increases the sensitivity of brain tissue to factors that act in adulthood.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

et al. 2014

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“…11 However, the opposite results -i.e., an increase in BDNF levels in stressed animals -have been reported by other authors, suggesting the existence of a compensatory mechanism in response to stress. 7 It is important to note that many of the changes found in animals exposed to stress procedures and that serve as criteria for face validation (such as anhedonia) and for construct validation (such as changes in the HPA axis and in neurotrophin levels) are reversed by various classes of clinically effective antidepressants (e.g., fluoxetine and imipramine), 12 demonstrating the predictive validity of this animal model. However, the CMS model has two major drawbacks.…”

Section: Chronic Mild Stressmentioning

confidence: 94%

Animal models as tools to study the pathophysiology of depression

Abelaira

Réus

Quevedo

2013

Rev. Bras. Psiquiatr.

199

116

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The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression. A basic understanding of the underlying disease processes in depression is lacking; therefore, recreating the disease in animal models is not possible. Popular current models of depression creatively merge ethologically valid behavioral assays with the latest technological advances in molecular biology. Within this context, this study aims to evaluate animal models of depression and determine which has the best face, construct, and predictive validity. These models differ in the degree to which they produce features that resemble a depressive-like state, and models that include stress exposure are widely used. Paradigms that employ acute or sub-chronic stress exposure include learned helplessness, the forced swimming test, the tail suspension test, maternal deprivation, chronic mild stress, and sleep deprivation, to name but a few, all of which employ relatively short-term exposure to inescapable or uncontrollable stress and can reliably detect antidepressant drug response.

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“…Patients with schizophrenia spectrum had a larger pituitary volume (larger in female than male patients), reflecting hyperactivity of the HPA axis, which may be related to a common vulnerability to stress in patients [63]. Dysregulation of HPA axis activity can be detected not only in depressed but also in schizophrenic patients [64,65], and the hypothesis of HPA axis hyperactivity in schizophrenia was supported by an experiment using a neurodevelopmental model of schizophrenia in rats [66]. HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis, and patients' diagnosis and clinical phase partially influence these associations [67].…”

Section: Hypothalamusmentioning

confidence: 99%

Females with schizophrenia have abnormal functional cortical connectivity in the gamma frequency during an auditory oddball task using magnetoencephalography

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2014

OJPsych

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We studied differences in imaginary coherence (IC) of the gamma band between brain regions of female schizophrenia patients during the auditory oddball task using magnetoencephalography (MEG). Subjects were 12 right-handed female schizophrenia patients, who were evaluated by the Positive and Negative Syndrome Scales (PANSS). Functional connectivity during an auditory oddball task was reconstructed in low gamma (30 -50 Hz) and high gamma (50 -100 Hz and 100 -150 Hz) bands, and represented by IC using seeds determined by the significant oscillatory power changes obtained by event-related synchronization (ERS) and event-related desynchronization (ERD) power measurements. Gamma ERS (30 -50 Hz) power was decreased in the left precuneus at 500 -750 ms and in the right precuneus at 750 -1000 ms. IC in the gamma band (50 -100 Hz) was decreased between the right precuneus (seed) and right paracentral lobule (target) and between the right precuneus and right hypothalamus at 0 -250 ms. IC in the gamma band (100 -150 Hz) was increased between the left precuneus and right cuneus (Brodmann area 7) at 250 -500 ms, between the left precuneus and right culmen at 500 -750 ms, and between the left precuneus and right cuneus (Brodmann area 17), between the left precuneus and right posterior cingulate cortex, and between the left precuneus and right caudate nucleus at 750 -1000 ms. In the high gamma band (50 -100 Hz) at 0 -250 ms, significant positive correlations were shown between IC and conceptual disorganization in PANSS scores, between IC and unusual thought content score, and between IC and positive scale score. IC within the high gamma band in female schizophrenia patients showed two types of functional disconnection, intrahemispheric and interhemispheric. IC between the right or left precuneus and other specific cortical areas showed dysfunction, suggesting that the parietal lobe plays an important role in dysfunction in connectivity in the gamma band during the oddball task.

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The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats

Cited by 105 publications

References 46 publications

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

Animal models as tools to study the pathophysiology of depression

Females with schizophrenia have abnormal functional cortical connectivity in the gamma frequency during an auditory oddball task using magnetoencephalography

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