The Effect of Antioxidantson Electrolytes in Vancomycin- Streptozotocin InducedDiabetes Kidney Disease inRabbits.

Abstract

Diabetes mellitus is a metabolic disease that is characterized by relative or absolute insulin deficiency, diabetic kidney disease (DKD) seems to be one of the most common complications of diabetes mellitus. Diabetic kidney disease was known as diabetic nephropathy (DN) and is the single strongest predictor of mortality in patients with diabetes. Forty male and female rabbits weighing 1000-1300 mg were divided randomly into five groups. Diabetes mellitus was induced in the overnight fasted rabbits by a single IP injection ofStreptozotocin in dose of 50 mg/kg. Then animals were started of antioxidant treatment, blood sampling were taken each 2 weak, the laboratory analysis which includes blood sugar, and serum electrolytes (potassium, sodium, and chloride).The various antioxidants were used in different combination in treated 1 group (quercetin15 mg/kg and L-carnitine15 mg/kg) and treated 2 group (quercetin15 mg/kg, L-carnitine15 mg/kg, Thioctic acid 20mg/kg, Vitamin C 15mg/kg) orally.There was a non-significant decrease in serum glucose level in treated 1 group andtreated 2 group (which treated with different combination of antioxidants) compared with diabetic control group and significant increase in serum (potassium, and chloride) but nonsignificant increase in serum sodium in treated groups compared with diabetic control group.The role of antioxidants as adjuvant therapy to decrease and prevent diabetic kidney disease through the scavenging effect to reactive oxygen species produced by diabetic kidney tissues.