The effect of antireflux treatment on the frequency of awakenings from sleep in patients with Gastroesophageal reflux disease

Jha, Lokesh K.; Maradey–Romero, Carla; Gadam, Rakshith; Hershcovici, Tiberiu; Fass, Ofer; Quan, Stuart F.; Guillén, José Ramón Oliver; Fass, Ronnie

doi:10.1111/nmo.12481

Cited by 15 publications

(5 citation statements)

References 44 publications

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“…Pantoprazole for 1.4 months improved all sleep disturbances in more than 75% of patients and resolved nGER symptoms . Interestingly, in a study using 24‐h esophageal pH testing with actigraphy, esomeprazole 40 mg once daily improved esophageal acid exposure during the recumbent awake, recumbent asleep, and conscious awakening periods; however, it did not improve objective sleep parameters, such as duration of recumbent awakening or frequency of conscious awakenings . In such refractory cases, using PPIs before dinner once daily or using PPIs twice daily would be effective in improving objective sleep parameters.…”

Section: Role Of Nocturnal Reflux Symptoms In Sleep Disordersmentioning

confidence: 99%

“…50 Interestingly, in a study using 24-h esophageal pH testing with actigraphy, esomeprazole 40 mg once daily improved esophageal acid exposure during the recumbent awake, recumbent asleep, and conscious awakening periods; however, it did not improve objective sleep parameters, such as duration of recumbent awakening or frequency of conscious awakenings. 60 In such refractory cases, using PPIs before dinner once daily or using PPIs twice daily would be effective in improving objective sleep parameters. Using PPI before dinner rather than before breakfast might have more effectively controlled the reflux-related awakenings during sleep.…”

Section: Effect Of Reflux Treatment On Sleepmentioning

confidence: 99%

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Gastroesophageal reflux disease: recent advances and its association with sleep

2016

Annals of the New York Academy of Sciences

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Gastroesophageal reflux disease (GERD) is prevalent in Asia as well as in Western countries. Sleep disturbance and breathing disorders during sleep are becoming increasingly prevalent, and they are commonly associated with GERD. The relationship between GERD and obstructive sleep apnea (OSA) is still questionable, and it has expanded to include Barrett's esophagus. Nocturnal gastroesophageal reflux (nGER) symptoms might be clinically important in the explanation of this association. The therapy for reflux symptoms has resulted in improved subjective sleep parameters and enhanced sleep quality, thus supporting a direct relationship between GERD and sleep disturbance. This review discusses the epidemiology of sleep disturbances in GERD patients; the causative relationship between GERD and OSA, even though it remains an area of controversy; and the possible role of nGER in sleep problems. It also provides an update on the current state of knowledge linking GERD and sleep.

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Section: Role Of Nocturnal Reflux Symptoms In Sleep Disordersmentioning

confidence: 99%

Section: Effect Of Reflux Treatment On Sleepmentioning

confidence: 99%

Gastroesophageal reflux disease: recent advances and its association with sleep

2016

Annals of the New York Academy of Sciences

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“…Persistent GERD symptoms may also lead to sleep deprivation, lower quality of life, and decreased work productivity [ 4 – 6 ]. In fact, more than 50% of GERD patients experience heartburn when awake [ 7 ], and nighttime reflux causes sleep disorders [ 4 ]. Therefore, it is important to diagnose and treat GERD before it progresses.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal reflux disease and its related factors among women of reproductive age: Korea Nurses’ Health Study

et al. 2018

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BackgroundRecently, the number of patients diagnosed with gastroesophageal reflux disease (GERD) has increased in Korea. Risk factors of GERD include age, sex, medication use, lack of physical exercise, increased psychological stress, low or high body mass index (BMI), unhealthy eating habits, increased alcohol consumption, and cigarette smoking. However, few studies examined the major factors affecting GERD in women of childbearing age. Therefore, this study assessed the risk factors of GERD among 20,613 female nurses of reproductive age using data from the Korea Nurses’ Health Study.MethodsParticipants were recruited from July 2013 to November 2014. They provided their history of GERD 1 year prior to data collection, along with information on their demographic characteristics, health-related behaviors, diet, medical history, and physical and psychological factors. Of the total sample, 1184 individuals with GERD diagnosed in the year prior to the study were identified. Propensity score matching was used for analysis.ResultsCigarette smoking, increased alcohol consumption, low or high BMI, depression, and increased psychosocial stress were associated with the prevalence of GERD among Korean young women. Multivariate ordinal logistic regression analysis revealed significant positive relationships between GERD and being a former smoker; having a low (< 18.5 kg/m2) or high BMI (> 23 kg/m2); and having mild, moderate, moderately severe, and severe depression.ConclusionsSmoking, BMI, and depression were associated with GERD. To reduce this risk among female nurses, intervention strategies are required to help nurses maintain a normal weight and manage their depression.

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“…Orr et al also used polysomnography to determine the effects of rabeprazole treatment and found that such treatment improved sleep quality (10). Meanwhile, Chand et al reported that the administration of esomeprazole was not associated with sleep efficiency (11) and Jha et al also reported that esomeprazole had no impact on the duration of the recumbentawake period and the frequency or duration of awakening to a conscious states in GERD patients (12). The reasons for these discrepancies in previous studies are unknown.…”

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confidence: 99%

“…Jha et al also reported that a subgroup exhibiting nonerosive reflux disease (NERD) with regurgitation had a significantly higher rate of impaired daily activity than a subgroup exhibiting erosive esophagitis with regurgitation particularly, regarding eating or drinking problems and work interference (12). In Japan, patients with NERD as well as erosive esophagitis were also reported to be affected by sleep impairment (1, 2).…”

mentioning

confidence: 99%