The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra-abdominal and epididymal fat and glucose levels in male Wistar rats

Silva, Raquel D'Agostini; Bueno, Audrin Loss Scopel; Gallon, Carin Weirich; Gomes, Luana Ferreira; Kaiser, Samuel; Pavei, Cabral; Ortega, George González; Kucharski, Luiz Carlos; Jahn, Matheus Parmegiani

doi:10.1016/j.fitote.2011.04.011

Cited by 32 publications

(22 citation statements)

References 30 publications

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“…In the positive control, in mice fed an HFD with yerba mate (MT), abdominal-to-peripheral adipose tissue weight was approximately 44.4% lower than that of the HFD-only group, whereas the epididymal fat weight was 3.7% higher. This result is consistent with previous reports that a crude “yerba mate” does not decrease epididymal adipose tissue weight in rats significantly [28,29]. …”

Section: Resultssupporting

confidence: 94%

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Seo

Goo

Chung

et al. 2017

IJMS

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Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity.

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Section: Resultssupporting

confidence: 94%

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Seo

Goo

Chung

et al. 2017

IJMS

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“…Besides several biological activities previously studied (Schenkel et al , ), particular attention has been paid to mate saponins anti‐obesity and atherosclerosis reduction effects (Mosimann et al , ; Pang et al , ; Arçari et al , ; Silva et al , ), anti‐viral activity (Müller et al , ), as well as their ability to form rather intricate elongated micelles (Peixoto et al , ). However, the biological studies on mate have so far focused mainly on crude extracts and non‐purified products.…”

Section: Introductionmentioning

confidence: 99%

LC‐UV Assay Method and UPLC/Q‐TOF‐MS Characterisation of Saponins from Ilex Paraguariensis A. St. Hil. (Mate) Unripe Fruits

Peixoto

Kaiser

Verza

et al. 2011

Phytochemical Analysis

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“…As metilxantinas são constituintes químicos derivados de bases púricas, as quais possuem nitrogênio heterocíclico e apresentam atividade fisiológica marcante (MEINHART et al, 2010;SILVA et al, 2011). Na erva mate, a principal metilxantina encontrada é a cafeína, seguida pela teobromina e em menores quantidades teofilina (CLIFFORD; RAMIREZ-MARTINEZ, 1990).…”

Section: Composição Química E Propriedades Biológicas Da Erva Mateunclassified

“…Na erva mate, a principal metilxantina encontrada é a cafeína, seguida pela teobromina e em menores quantidades teofilina (CLIFFORD; RAMIREZ-MARTINEZ, 1990). Essa classe de compostos é responsável por exercer efeitos estimulantes ao sistema nervoso central, cardiovascular, renal, digestivo e por elevar a utilização de gordura como fonte energética (DERMARDEROSIAN, 2001;WICHTL, 2003;RATES, 2007, SILVA et al, 2011.…”

Section: Composição Química E Propriedades Biológicas Da Erva Mateunclassified

Microencapsulação por spray drying dos compostos bioativos do extrato aquoso de erva mate (Ilex paraguariensis) crioconcentrado

Nunes

Menezes

2015

CeN

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Microencapsulação por spray drying dos compostos bioativos do extrato aquoso de erva mate (Ilex paraguariensis) crioconcentrado Microencapsulation by spray drying of bioactive compounds of yerba mate extract aqueous (Ilex paraguariensis) freeze concentration Resumo Nos diversos trabalhos científicos têm sido demonstrados os efeitos benéficos da Ilex paraguariensis, principalmente relacionados às suas propriedades antioxidantes, devido ao alto teor de compostos fenólicos presentes em seu extrato aquoso. Dessa forma, a aplicação de tecnologias de concentração, tais como, a crioconcentração torna-se relevante, uma vez que promove a concentração de produtos alimentares, através do congelamento e subsequente separação de uma parte da água congelada, a partir de um produto líquido, resultando em um aumento no teor de compostos fenólicos do extrato aquoso de folhas de erva mate, e na minimização de perdas destes compostos. Devido ao alto teor de compostos fenólicos, o extrato crioconcentrado de erva mate se torna instável, sendo susceptível à degradação pela ação de alguns fatores, como presença de oxigênio, luz, pH e temperatura e assim a aplicação de processos de microencapsulação, tais como a atomização se apresenta como uma alternativa importante na melhoria da estabilidade dos compostos fenólicos do extrato aquoso crioconcentrado das folhas de erva mate. Palavras-chave: Erva mate. Crioconcentração. Microencapsulação. Spray dryer. AbstractSeveral scientific studies have shown the beneficial effects of yerba mate, mainly related to its antioxidant properties, due to the high content of phenolic compounds present in the aqueous extract. In this context, the application concentration technologies, such as the freeze concentration becomes relevant, since it promotes concentration of food by freezing and subsequent separation of a part of the frozen water, from a liquid product, resulting in an increase in the content of phenolic compounds from aqueous extract of yerba mate leaves, and minimizing losses of these compounds. Due to the high content of phenolic compounds, the freeze concentration of yerba mate extract becomes unstable and is susceptible to degradation by the action of some factors such as the presence of oxygen, light, pH and temperature and so the application of microencapsulation processes such as atomization presents itself as an important alternative in improving the stability of the phenolic compounds of the aqueous extract of freeze concentration of yerba mate leaves.

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The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra-abdominal and epididymal fat and glucose levels in male Wistar rats

Cited by 32 publications

References 30 publications

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

LC‐UV Assay Method and UPLC/Q‐TOF‐MS Characterisation of Saponins from Ilex Paraguariensis A. St. Hil. (Mate) Unripe Fruits

Microencapsulação por spray drying dos compostos bioativos do extrato aquoso de erva mate (Ilex paraguariensis) crioconcentrado

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