The Effect of Aqueous Solution of Silver Nanoparticles on Rat Behavior

Егорова, Елена; Krupina, N. A.; Каба, С.И.; Хлебникова, Н. Н.; Shirenova, S.; Свиридкина, Н.Б.; Pal'tsyn, A. A.

doi:10.1134/s2635167622020082

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…Increased sensitivity may also be regarded as a positive marker of a productive adaptation. An increase of locomotor activity is regarded as the compensatory to increased anxiety [26]. The locomotor activity increase as well as the tendency to the long-term memory improvement can be considered as the compensatory to the anxiety increase in the present case.…”

Section: Discussionmentioning

confidence: 80%

“…In contrary to that, an increase of locomotor activity and decrease of anxious-phobic level in a stressful environment as well as impairment of short-term addiction of rats after 2-month exposure to 16.7 nm sized beta-cyclodextrin coated nanosilver were observed. Extra 3 months of washing out resulted in no differences in behavioral functions and the ability for associative learning between experimental and control animals [26]. While silver particles in the brain regions of rats were detected in 2 months of the exposure using electron microscopy, however none of them were found in the extra 3 months of washing out.…”

Section: Introductionmentioning

confidence: 80%

“…There are works demonstrating the influence of silver nanoparticles on the behavioral and cognitive functions of laboratory mammals. Negative adverse effects [22][23][24][25] as well as improvement of behavioral functions [26,27] at silver nanoparticle exposure are shown. For example, a memory impairment, learning and motor function as well as social behavior change were observed after intravenous exposure of mice to silver nanoparticles in [22].…”

Section: Introductionmentioning

confidence: 93%

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Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Antsiferova,

Kopaeva,

Loginova

et al. 2023

Preprint

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Pure silver as well as silver compounds have been used as antiseptics for centuries. Nowadays, the most frequently applied form of silver is a nanoparticle form. Several studies demonstrate the ability of silver nanoparticles and silver salts to accumulate in the brain of laboratory ani-mals as well as the ability of silver nanoparticles to influence behavioral and cognitive functions of laboratory mammals. For the first time, the influence of a silver salt, in particular, silver citrate on the change dynamics of behavioral and cognitive functions of laboratory mice at the daily oral exposure during 30, 60, 120 and 180 days is investigated in the present research. We observed the anxiety increase after 30 days of the exposure as well as the ability of mice to adapt to the prolonged oral exposure of silver citrate manifested in the anxiety decrease, increase of locomotor activity and the tendency of long-term contextual memory improvement. Increase of locomotor activity and memory improvement might be associated with the sensitivity increase and regarded as compensatory mechanism to anxiety increase. The observed phenomenon is classified as a hormetic effect. A comparison with the analogous study implemented polyvi-nylpyrrolidone coated silver nanoparticles is carried out. It was concluded that the nanoform is more neurotoxic.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 93%

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Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Antsiferova,

Kopaeva,

Loginova

et al. 2023

Preprint

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“…Nonetheless, some works regard influence of Ag NPs on cognitive and behavioral functions. They demonstrate the presence of such an influence: negative [14][15][16] and positive [17]. However, there are no researches investigating influence of Ag salts on cognitive and behavioral functions despite the fact that silver in the salt form may accumulate in the brain [6,7].…”

Section: Introductionmentioning

confidence: 99%

Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

Antsiferova¹,

Kopaeva²,

Кашкаров³

2022

Preprint

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Silver in different forms is used for medical purposes from ancient times. It is not yet well known, which form of silver is more biocompatible and less toxic. Here we considered silver nanoparticles and silver citrate. Also, the relationships of neurotoxicity of silver compaunds with ageing factor is not yet described. To assess the role of nanoform in neurotoxicity of silver and role of ageing a long-term experiment was conducted. We had four control groups of intact mice and four experimental groups which were exposed to silver nanoparticles and silver citrate for two months. Four groups of mice were introduced into the experiment since the age of five months to assess ageing factors. It was shown that the nanoform does play a certain role in neurotoxicity of silver. Silver citrate seems to be a more preferable silver compound. Ageing can be regarded as a positive factor that neutralizes toxic action of silver compounds. It may be due to the development of physiological/cognitive functions with the age as well as adaptation to unnatural content in the individual cages that is definitely stressful for mice.

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Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

2022

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The Effect of Aqueous Solution of Silver Nanoparticles on Rat Behavior

Cited by 4 publications

References 46 publications

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

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