The effect of arginine supplementation on growth hormone release and intestinal mucosal growth after massive small bowel resection in growing rats

Hebiguchi, Tatsuzo; Kato, Taichi; Yoshino, Hiroaki; Morita, Masaru; Koyama, Kenji

doi:10.1016/s0022-3468(97)90672-2

Cited by 21 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alike, highly significant increase was found in the Index in the animals under glycine treatment. Glycine has previously been shown to stimulate the growth hormone (GH) production [32,33], corroborating the results for NAL and Lee Index, due the anabolic effect of GH. Opposed to glycine, neonatal MSG treatment caused shorter NAL and lower Lee Index compared to control animals.…”

Section: Discussionsupporting

confidence: 70%

Early glycine supplementation re-establishes adrenal catecholamine secretion in hypothalamic obesity model in rats but does not affect visceral adiposity.

Andreazzi

Silva

Chaves

et al. 2015

JGM

View full text Add to dashboard Cite

Obesity is a worldwide epidemic that features a multifactorial syndrome characterized by a chronic positive energetic unbalance. Neonatal administration of monosodium L-glutamate (MSG) causes lesion on the arcuate nucleus of hypothalamus that led to development of obesity in the adult life in rodents characterized by a notorious accumulation of catecholamine in the adrenal medulla. The amino acid glycine induces catecholamine secretion of adrenal medulla. Thus, the objective of our work was to evaluate the possible effects of glycine administration in the MSG-obesity model in rats and investigate its impact on adrenal catecholamine medulla homeostasis. Male Wistar rats received MSG solution (4mg/g body weight)subcutaneously in the cervical area for 5 days after delivery, controls received saline solution. Animals were also divided in two groups, in which one received tap water added with glycine (0.1g/Kg) after weaning on 21 st day until 90 days of life. Biometrical variables, visceral fat pads weight, total content and basal secretion of adrenal cathecolamine were evaluated. Glycine increased Lee index of all tested groups and had no effect on visceral adiposity. However, glycine treatment completely reestablished catecholamine total content and basal secretion of MSG-obese group. In conclusion, although glycine treatment apparently completely reestablishes catecholamine secretion homeostasis it is not sufficient to significant directly reduce visceral adiposity in MSG obesity model in rats. DOI : 10.14302/issn.2572-5424.jgm-14-604Corresponding author: Ana Eliza Andreazzi, Laboratory of Physiology, Department of Physiology Federal University of Juiz de Fora, Rua José Lourenço Kelmer, s/n -Campus Universitário , Bairro São Pedro -CEP: 36036-900 -Juiz de Fora -MG/Brazil, E-mail: anaeliza.andreazzi@ufjf.edu.brRunning title: Glycine reestablishes catecholamine secretion in MSG-rats.

show abstract

Section: Discussionsupporting

confidence: 70%

Early glycine supplementation re-establishes adrenal catecholamine secretion in hypothalamic obesity model in rats but does not affect visceral adiposity.

Andreazzi

Silva

Chaves

et al. 2015

JGM

View full text Add to dashboard Cite

show abstract

“…4 The plasma Arg level was significantly low 3 weeks after surgery in rats without Arg supplementation. In addition, the plasma Arg level was also low 6 weeks after surgery.…”

Section: Discussionmentioning

confidence: 90%

Renal Focal Tubulointerstitial Fibrosis with Short Bowel Syndrome: Report of a Case

et al. 2002

Self Cite

View full text Add to dashboard Cite

We report a male patient with short bowel syndrome (SBS) and renal focal tubulointerstitial fibrosis (FTIF). Seven years after surgery, he was introduced to us due to severe undernutrition, an impairment of growth hormone (GH) secretion, and abnormally low levels of plasma citrulline and arginine at 11 years 7 months of age, just before nutritional support using total parenteral nutrition (TPN) was begun. Thereafter, the support was changed to home TPN with GH supplementation. After an improvement of the disorders, GH was stopped at 17 years 3 months of age. However, hyperuricemia appeared and a renal biopsy revealed FTIF at 20 years of age. Home TPN was continued twice a week because the plasma arginine level was still low. His follow-up biopsy at 23 years of age showed morphometric amelioration. Arginine deficiency following SBS may be associated with FTIF. The cause of hyperuricemia after SBS therefore needs to be investigated in detail.

show abstract

“…It has been reported that ornithine alpha-ketoglutarate, which is a precursor of arginine, enhances intestinal adaptation after massive resection in the rat and improves muscle glutamine and protein content [11]. Hebiguchi and colleagues reported that arginine supplementation in the diet resulted in a significant increase in ileal villus height compared with control animals; they concluded that arginine stimulates mucosal growth after massive bowel resection, probably through stimulation of growth hormone secretion [13]. Arginine may also influence intestinal adaptation through production of polyamine [9] or NO.…”

Section: Discussionmentioning

confidence: 99%

Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model

et al. 2005

View full text Add to dashboard Cite

The nitric oxide precursor L-arginine (ARG) has been shown to influence intestinal structure and absorptive function. It is also well known that the route of administration modulates the effects of ARG. The present study evaluated the effects of parenteral ARG on structural intestinal adaptation, cell proliferation, and apoptosis in a rat model of short bowel syndrome (SBS). Male Sprague-Dawley rats were divided into three experimental groups: Sham rats underwent bowel transection and reanastomosis, SBS rats underwent a 75% small bowel resection, and SBS-ARG rats underwent a 75% small bowel resection and were treated with ARG given subcutaneously at a dose of 300 mug/kg, once daily, from days 3 to 14. Parameters of intestinal adaptation, enterocyte proliferation, and enterocyte apoptosis were determined on day 15 following operation. The SBS rats demonstrated a significant increase in jejunal and ileal bowel and mucosal weight, villus height and crypt depth, and cell proliferation index compared with the sham group. The SBS-ARG animals demonstrated lower ileal bowel and mucosal weights, jejunal mucosal DNA and ileal mucosal protein, and jejunal and ileal villus height and crypt depth compared with SBS animals. The SBS-ARG rats also had a lower cell proliferation index in both jejunum and ileum and a greater enterocyte apoptotic index in ileum compared with the SBS-untreated group. In conclusion, in a rat model of SBS, parenteral arginine inhibits structural intestinal adaptation. Decreased cell proliferation and increased apoptosis are the main mechanisms responsible for decreased cell mass.

show abstract

The effect of arginine supplementation on growth hormone release and intestinal mucosal growth after massive small bowel resection in growing rats

Cited by 21 publications

References 9 publications

Early glycine supplementation re-establishes adrenal catecholamine secretion in hypothalamic obesity model in rats but does not affect visceral adiposity.

Early glycine supplementation re-establishes adrenal catecholamine secretion in hypothalamic obesity model in rats but does not affect visceral adiposity.

Renal Focal Tubulointerstitial Fibrosis with Short Bowel Syndrome: Report of a Case

Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model

Contact Info

Product

Resources

About