The effect of ascorbic acid on the photophysical properties and photodynamic therapy activities of zinc phthalocyanine-single walled carbon nanotube conjugate on MCF-7 cancer cells

Ogbodu, Racheal O.; Nyokong, Tebello

doi:10.1016/j.saa.2015.06.063

Cited by 37 publications

(18 citation statements)

References 66 publications

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“…On the opposite side, the group treated with PDT (Group 4) resulted in a noticeable tumor reduction and, even more important, when treated in synergy with NIR photo-thermal therapy (Group 5) [122]. There results suggests great promise for PDT [123,124], especially in combination with other therapies [125,126,127]. …”

Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

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Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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“…[1] In particular, transition-metal phthalocyanines are widely used as dyes in the textile industry, accounting for around 25% of all organic pigment production worldwide. [2] They are also important in medical applications, filling niche roles as photo-sensitizing agents in anti-cancer photodynamic therapy, [3,4,5,6,7] and as contrast agents for magnetic resonance imaging. [8] Over the past 5-10 years, transition-metal phthalocyanines have become the focus of intense and resurgent interest, due to their potential applications in molecular electronics; as key components of light-emitting diodes and organic photovoltaic materials.…”

Section: Introductionmentioning

confidence: 99%

CASSCF-based explicit ligand field models clarify the ground state electronic structures of transition metal phthalocyanines (MPc; M = Mn, Fe, Co, Ni, Cu, Zn)

2016

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Multireference electronic structure methods are used to assign ground state electronic configurations for a series of metallophthalocyanines. Ligand orbital occupancies remain constant across the period and are consistent with a formal 2– charge on the ligand. The d electron configurations of some metallophthalocyanines are straightforward and can be unambiguously assigned, (dxy)2(dxz,dyz)2,2( [Formula: see text])2([Formula: see text])n, with n = 2, 1, 0, respectively, for ZnPc, CuPc, and NiPc. Controversies over ground state electronic structure assignments for other metallophthalocyanines arise due to multiple complicating factors: accidental near-degeneracies, environmental effects, and different ligand field models used in interpreting experimental spectra. We demonstrate that explicit ligand field models provide more reliable and consistent interpretations of experimental data than implicit, parameterized alternatives. On this basis, we assign gas-phase electronic ground states for MnPc, (dxy)2(dxz,dyz)1,1([Formula: see text])1 and CoPc, (dxy)2(dxz,dyz)2,2([Formula: see text])1, and show that the ground state of FePc cannot be resolved to a single state, with two near-degenerate states that are likely spin-orbit coupled: (dxy)2(dxz,dyz)1,1( [Formula: see text])2 and (dxy)2(dxz,dyz)2,1([Formula: see text])1. Remaining differences between computational predictions and experimental observations are small and may be ascribed primarily to environmental effects but are also partly due to incomplete modelling of electron correlation.

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“…[43] Nyokongs group reported that SWCNTs had the ability to increase the effect of zinc monocarboxylphenylphthalocyaninei nPDT. [44] 3.1.4. Peptide-Based Nanoparticles Peptide-based nanoparticles,a sau nique type of drug carrier,h ave received more attention because of their stability,l ow cost, long-term storage,f unctional disposition, low immunogenicity,a nd easy handling.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

2019

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The viable use of photodynamic therapy (PDT) in cancer therapy has never been fully realized because of its undesirable effects on healthy tissues. Herein we summarize some physicochemical factors that can make PDT a more viable and effective option to provide future oncological patients with better‐quality treatment options. These physicochemical factors include light sources, photosensitizer (PS) carriers, microwaves, electric fields, magnetic fields, and ultrasound. This Review is meant to provide current information pertaining to PDT use, including a discussion of in vitro and in vivo studies. Emphasis is placed on the physicochemical factors and their potential benefits in overcoming the difficulty in transitioning PDT into the medical field. Many advanced techniques, such as employing X‐rays as a light source, using nanoparticle‐loaded stem cells and bacteriophage bio‐nanowires as a photosensitizer carrier, as well as integration with immunotherapy, are among the future directions.

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The effect of ascorbic acid on the photophysical properties and photodynamic therapy activities of zinc phthalocyanine-single walled carbon nanotube conjugate on MCF-7 cancer cells

Cited by 37 publications

References 66 publications

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

CASSCF-based explicit ligand field models clarify the ground state electronic structures of transition metal phthalocyanines (MPc; M = Mn, Fe, Co, Ni, Cu, Zn)

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

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