The effect of Asian dust on asthma by socioeconomic status using national health insurance claims data in Korea

Park, Yoon-Sung; Kim, Jeong-Hee; Jang, Hae-Ji; Tae, Yoon-Hee; Lim, Dae Hyun

doi:10.3109/08958378.2015.1123331

Cited by 16 publications

(10 citation statements)

References 18 publications

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“…Genes showing differential expression included those involved in the cell cycle, cholesterol biosynthesis, and platelet activation. A more recent study partially confirmed these results [ 114 ]. In fact, analysis of the liver proteome and transcriptome showed upregulation of several enzymes involved in fatty acid and cholesterol metabolism upon CS inhalation.…”

Section: Apoe −/− Mouse Model To Investigate Toxicsupporting

confidence: 63%

“…The effects of CS exposure and smoking cessation were also determined on hepatic lipid, transcriptomic, and proteomic profiles in Apoe −/− mice [ 114 , 116 , 118 ]. De Leon and colleagues [ 118 ] showed that the concentrations of many lipids, including free cholesterol, ceramides, and sphingomyelin, decreased in the liver of Apoe −/− mice following smoking cessation, although the triacylglycerol concentration increased.…”

Section: Apoe −/− Mouse Model To Investigate Toxicmentioning

confidence: 99%

“…These data suggested that smoking alone cannot be regarded as a causative agent for liver diseases but, rather, as an accelerator in the presence of synergistic factors (alcohol, chronic liver diseases) [ 121 – 123 ]. Finally, these changes were significantly reduced or absent when mice were exposed continuously to the cMRTP aerosol, upon cessation regimen or switching to the cMRTP [ 114 ].…”

Section: Apoe −/− Mouse Model To Investigate Toxicmentioning

confidence: 99%

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The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Schlage²,

et al. 2016

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Atherosclerosis-prone apolipoprotein E-deficient (Apoe−/−) mice display poor lipoprotein clearance with subsequent accumulation of cholesterol ester-enriched particles in the blood, which promote the development of atherosclerotic plaques. Therefore, the Apoe−/− mouse model is well established for the study of human atherosclerosis. The systemic proinflammatory status of Apoe−/− mice also makes them good candidates for studying chronic obstructive pulmonary disease, characterized by pulmonary inflammation, airway obstruction, and emphysema, and which shares several risk factors with cardiovascular diseases, including smoking. Herein, we review the results from published studies using Apoe−/− mice, with a particular focus on work conducted in the context of cigarette smoke inhalation studies. The findings from these studies highlight the suitability of this animal model for researching the effects of cigarette smoking on atherosclerosis and emphysema.

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Section: Apoe −/− Mouse Model To Investigate Toxicsupporting

confidence: 63%

Section: Apoe −/− Mouse Model To Investigate Toxicmentioning

confidence: 99%

Section: Apoe −/− Mouse Model To Investigate Toxicmentioning

confidence: 99%

See 1 more Smart Citation

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Schlage²,

et al. 2016

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“…3 Due to increase in incidence and prevalence of asthma, direct and indirect costs of this disease are amplifying. 4,5 Present study, was conducted with the aim of calculating the direct costs of pediatric asthma in Tehran-Iran.…”

Section: Introductionmentioning

confidence: 99%

Direct Costs of Asthma in a Referral Public Children's Hospital in Tehran, Iran

Rostamzadeh

Sari

Gharagozlou

2019

IJAAI

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Asthma is one of the most common chronic diseases all over the world, which impacts socioeconomics of families and health care systems. We need to estimate the costs of asthma to set health policies and structural adjustments to control burden of asthma in societies. The aim of present study was to evaluate direct costs of asthma in children in Tehran-Iran. In a descriptive-analytical study, 100 children who were referred to Children’s Medical Center of Tehran University of Medical sciences, from March 2014 to March 2015, were selected randomly and studied. In an interview with parents we evaluated direct costs of asthma including physician fees, admission fees, medication costs, costs of transportation, and others. In present study, 72 patients (72.0%) were male and 28 patients (28.0%) were female with mean age of 6.9±0.3 years old. Annual mean of direct costs of outpatient care were calculated 5,179,000±620,000 Rials (159.3±19$), and with considering the admission costs, direct medical expenditure were calculated 6,069,600±140,000 Rials (186.7±4$) throughout the year. Non-medical annual costs of asthma in children were calculated 4,439,700±437,540 Rials (136.6±13$) during 2014-2015 in Tehran-Iran. Based on findings of present study, total costs of asthma with the help of close physician follow ups and effective usage of medications has decreased in recent decades; furthermore, in our study, outpatient management costs which accounted for 85.5% of total direct costs of asthma in children, had the largest share of direct costs of asthma management

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“…Asian sand dust (ASD) (known as Kosa aerosol) originating from the arid deserts of Mongolia and China, causes severe air pollution annually in the Asia-Pacific area, including China, Korea, and Japan [ 1 , 2 ]. Epidemiological studies of ASD show that human exposure to ambient ASD particles is associated with an increase in pulmonary and cardiovascular problems and an increase in daily mortality in Korea [ 3 , 4 ], Taiwan [ 5 ], and Japan [ 6 , 7 ]. The frequency and scale of dust events giving rise to ASD aerosols have increased rapidly in the east Asian region since 2000 [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Pathological Study of Acute Pulmonary Toxicity Induced by Inhaled Kanto Loam Powder

Kobayashi

Shimada

Morita

et al. 2018

IJMS

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The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced by inhalation of ASD, ICR mice were exposed by inhalation to 50 or 200 mg/m3 Kanto loam powder, which resembles ASD in elemental composition and particle size, for 6 h a day over 1, 3, 6, 9, or 15 consecutive days. Histological examination revealed that Kanto loam powder induced acute inflammation in the whole lung at all the time points examined. The lesions were characterized by infiltration of neutrophils and macrophages. The intensity of the inflammatory changes in the lung and number of neutrophils in both histological lesions and bronchoalveolar lavage fluid (BALF) appeared to increase over time. Immunohistochemical staining showed interleukin (IL)-6- and tumor necrosis factor (TNF)-α-positive macrophages and a decrease in laminin positivity in the inflammatory lesions of the lung tissues. Electron microscopy revealed vacuolar degeneration in the alveolar epithelial cells close to the Kanto loam particles. The nitric oxide level in the BALF increased over time. These results suggest that inhaled Kanto loam powder may induce diffuse and acute pulmonary inflammation, which is associated with increased expression of inflammatory cytokines and oxidative stress.

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The effect of Asian dust on asthma by socioeconomic status using national health insurance claims data in Korea

Abstract: Our study confirms that Asian dust events result in an increased number of asthma-related visits to medical institutions. This effect differed by socioeconomic status.

Cited by 16 publications

References 18 publications

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Direct Costs of Asthma in a Referral Public Children's Hospital in Tehran, Iran

A Pathological Study of Acute Pulmonary Toxicity Induced by Inhaled Kanto Loam Powder

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