The Effect of Assisted Hatching on Live Birth Rate Following Fresh Embryo Transfer in Advanced Maternal Age

Tannus, Samer; Cohen, Yoni; Henderson, Sara; Son, Weon‐Young; Tulandi, Togas

doi:10.1177/1933719118799192

Cited by 11 publications

(15 citation statements)

References 30 publications

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“…Literature defined advanced maternal age often as maternal age ≥ 35 years because of increased many pregnancy complications. Low parity is defined as parity 1 -4 (the delivery of the second to the fourth baby) (11). In the present study, we used parity 1, as a reference category.…”

Section: Methodsmentioning

confidence: 99%

Effect of Grand Multiparity on Pregnancy Outcomes in Women Under 35 Years of Age: a Comparative Study

et al. 2019

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Introduction: It is known for many years, that grand multiparity is associated with poor pregnancy outcome with or without considering increasing maternal age. Aim: To examine the impact of grand multiparity on pregnancy outcome in young women aged 18–34 years (Young grand multiparas). Material and Methods: A prospective comparative cross-sectional study conducted at Omdurman Maternity Hospital, Sudan from January to September 2018. A standard questionnaire was used to gather data on pregnancy outcome in the low-risk group, grand multiparas age < 35 years and grand multiparas age ≥ 35 years. The association between variables was tested with Chi-square test. Results: Young grand multiparas have a significant risk of PPH and increased length of hospital stay => 3 days and babies born to young grand multiparas women were more likely of low birth weight and have a higher rate of admission to NICU. Young grand multiparas were similar in their maternal and fetal complication to low-risk pregnancies and significantly less in several complications when compared to older grand multiparas women. Conclusion: Young grand multiparas are less likely to develop several pregnancy complications compared to older grand multiparas women. The occurrences of intra-partum complications match that in low-risk pregnancy.

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Section: Methodsmentioning

confidence: 99%

Effect of Grand Multiparity on Pregnancy Outcomes in Women Under 35 Years of Age: a Comparative Study

et al. 2019

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“…18,29 Although AH can improve clinical pregnancy rates, some reports have revealed that AH does not significantly increase birth rate. 3,15,19,45 Miyata et al demonstrated that AH of thawed human blastocysts near the ICM resulted in a significantly higher rate of complete hatching, 11 while Ren et al reported that the site of AH did not influence implantation, pregnancy, or live birth rate during human vitrified-warmed blastocyst transfer cycles. 46 However, we convincingly demonstrated that AAH treatment in mice at the B-site of expanding blastocysts, which mimics natural hatching in vitro, dramatically improved birth rate (77.1%) compared with AAH at the C-site (55.3%).…”

Section: Discussionmentioning

confidence: 99%

“…The process of AH was initially developed to achieve artificial manipulation of the ZP, mediate embryo hatching, and improve the rate of embryo implantation, 18,29 although the full extent of AH’s beneficial effects in human embryos related to pregnancy and birth outcomes is scarce in published literature 18,29 . Although AH can improve clinical pregnancy rates, some reports have revealed that AH does not significantly increase birth rate 3,15,19,45 . Miyata et al demonstrated that AH of thawed human blastocysts near the ICM resulted in a significantly higher rate of complete hatching, 11 while Ren et al reported that the site of AH did not influence implantation, pregnancy, or live birth rate during human vitrified‐warmed blastocyst transfer cycles 46 .…”

Section: Discussionmentioning

confidence: 99%

Site specificity of blastocyst hatching significantly influences pregnancy outcomes in mice

Liu

et al. 2021

The FASEB Journal

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Blastocysts hatch from the zona pellucida (ZP) to enable implantation into the uterine endometrial epithelium, but little is known regarding the effect of hatching sites on pregnancy outcomes. Murine hatching embryos were categorized into five groups based on initial trophectoderm projection (TEP)/ZP position corresponding to the inner cell mass center. In blastocysts (3.5 dpc) post-12 hours in vitro culture, TEP rates of A-site (44.4%) and B-site (38.6%) embryos were higher than those of C-site (12.5%) and D-site (3.1%) embryos, while the O-site (1.4%) was the lowest (P < .05). Post-ET A-site (55.6%) and B-site (65.6%) birth rates were higher than

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“…There is some evidence that embryo stage may influence the outcomes of AH. Tannus et al demonstrated in a retrospective study on fresh embryo transfers in women aged 40 and above that AH was associated with reduced live birth rate with cleavage stage embryos but not with blastocysts [34]. In addition, with current methods of vitrification, thawed blastocysts may not benefit from AH as much as they did with past freeze-thaw techniques.…”

Section: Discussionmentioning

confidence: 99%

Assisted hatching of vitrified-warmed blastocysts prior to embryo transfer does not improve pregnancy outcomes

Wais²,

Nichols³

et al. 2020

J Ovarian Res

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Objective: This study aims to determine the impact of assisted hatching (AH) on pregnancy outcomes in vitrifiedwarmed blastocyst transfers, and evaluate if embryo expansion or morphology influences outcomes. Methods: A retrospective cohort study was performed including vitrified-warmed blastocyst transfers at our clinic between 2013 and 2017. Of the 2165 embryo transfers, 1986 underwent laser AH and 179 were non-assisted hatched (NAH). The primary outcome was live birth. Secondary outcomes included conception, implantation, clinical pregnancy, clinical pregnancy loss, and monozygotic twinning (MZT). Results: AH and NAH groups had similar rates of conception (38.7% vs 42.1%), implantation (26.2% vs 27.3%), clinical pregnancy (29.1% vs 30.3%), clinical pregnancy loss (24.0% vs 17.8%), live birth (19.9% vs 20.5%), and MZT (2.08% vs 2.86%). Five pairs of dichorionic/diamniotic twins resulted from single embryo transfers. AH of embryos with expansion grades ≤3 was associated with lower rates of conception (32.5% vs 44.3%%, p < 0.05) and clinical pregnancy (24.0% vs 32.8%, p < 0.05). Conclusion: AH prior to transfer of vitrified-warmed blastocysts was not associated with improved pregnancy outcomes. The identification of dichorionic/diamniotic twins from single blastocyst transfers challenges the previously held notion that dichorionic/diamniotic MZTs can only occur from division prior to the blastocyst stage. Prospective studies are needed to validate the novel finding of lower rates of conception and clinical pregnancy after AH in embryos with lower expansion grade.

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The Effect of Assisted Hatching on Live Birth Rate Following Fresh Embryo Transfer in Advanced Maternal Age

Abstract: Assisted hatching does not improve the reproductive outcomes in advanced maternal age. Performing routine AH for the sole indication of advanced maternal age is not clinically justified.

Cited by 11 publications

References 30 publications

Effect of Grand Multiparity on Pregnancy Outcomes in Women Under 35 Years of Age: a Comparative Study

Effect of Grand Multiparity on Pregnancy Outcomes in Women Under 35 Years of Age: a Comparative Study

Site specificity of blastocyst hatching significantly influences pregnancy outcomes in mice

Assisted hatching of vitrified-warmed blastocysts prior to embryo transfer does not improve pregnancy outcomes

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