2006
DOI: 10.1016/j.ijcard.2005.08.032
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The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery

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Cited by 13 publications
(9 citation statements)
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References 18 publications
(17 reference statements)
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“…There was also no significant change in the HRV of the patients receiving simvastatin only. This finding is consistent with some previous studies (Gentlesk et al, 2005;Riahi et al, 2006), although others have reported increased HRV parameters after statin therapy in hypercholesterolemia patients (Pehlivanidis et al, 2001). The pleiotropic effect of statins on autonomic nervous function was still undetermined, requiring further investigation in several disease subsets.…”
Section: Discussionsupporting
confidence: 92%
“…There was also no significant change in the HRV of the patients receiving simvastatin only. This finding is consistent with some previous studies (Gentlesk et al, 2005;Riahi et al, 2006), although others have reported increased HRV parameters after statin therapy in hypercholesterolemia patients (Pehlivanidis et al, 2001). The pleiotropic effect of statins on autonomic nervous function was still undetermined, requiring further investigation in several disease subsets.…”
Section: Discussionsupporting
confidence: 92%
“…In contrast, in a larger randomized double-blind placebocontrolled cross-over trial of 80 patients with diagnosed coronary artery disease, 6 weeks of high-dose atorvastatin (80 mg/day) reduced total cholesterol and LDL-cholesterol, but did not alter time domain HRV [98]. Similar neutral HRV results have been observed in a controlled observational study of 54 coronary artery disease patients with an implanted cardioverter defibrillator on statins [99].…”
Section: Coronary Artery Diseasementioning
confidence: 53%
“…Within the central nervous system, ER alpha is found in the preganglionic autonomic centers of the brain stem that are involved in cardiovascular regulation [4]. The autonomic nervous system plays a role in controlling the heart rate (HR) and vascular tonus, thereby helping to maintain homeostasis [35] and influencing cardiorespiratory capacity [69] and lipid profiles [10–12]. …”
Section: Introductionmentioning
confidence: 99%
“…Previous studies have shown an inverse relationship between low HRV indices and high serum levels of total and LDL cholesterol in men with ischemic heart disease [10] and patients with coronary artery disease [11]. In addition, studies have shown that variations in plasma lipids depend on estrogen levels [13,14].…”
Section: Introductionmentioning
confidence: 99%
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