The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease

Cellular cholesterol efflux to plasma from moderately hypercholesterolaemic type 1 diabetic patients is enhanced, and is unaffected by simvastatin treatment

“…Notably, pre-β HDL formation tended to decrease after simvastatin treatment, and these changes were correlated positively with the changes in plasma triglyceride and negatively with the changes in HDL cholesterol. Taken together, the present data suggest that statin treatment induces a shift towards more mature HDL particles, as was found in type 2 diabetic patients with ischaemic heart disease [52].…”

Effects of Atorvastatin on Nuclear Magnetic Resonance-Defined Lipoprotein Subclasses and Inflammatory Markers in Patients with Hypercholesterolemia

“…This finding, together with the reductions of plasma TG, RLP-C, apoC-, apoC-, and apoE, can be interpreted as indicating that atorvastatin has a favorable effect on TG-rich lipoprotein metabolism. Although there are no previous studies to which our NMR data can be directly compared, the predominant reduction of dense LDL subclasses is supported by other NMR studies using patients with hypertriglyceridemia with 10) or without 11) hypercholesterolemia. Indeed, in vivo kinetic studies demonstrated the decreased production as well as increased clearance of VLDL, an observation consistent with the inhibition of VLDL secretion via the strong inhibition of HMG-Co reductase activity and increased direct uptake by an up-regulated LDL receptor 12,13) .…”

The High Molecular Weight Adiponectin Level is Associated with the Atherogenic Lipoprotein Profiles in Healthy Japanese Males

“…Another important finding of our study is that both the total and HMW adiponectin levels were positively correlated with the cholesterol levels in the larger HDL subclass, which has been identified in several studies as the most cardioprotective HDL component 18,19,32) . The cholesterol ester transport protein can mediate an exchange of cholesterol ester on HDL for the VLDL-TG 27,29) .…”