The effect of autologous fibrin sealant (Vivostat�) on morbidity after pulmonary lobectomy: a prospective randomised, blinded study

Belboul, Ali; Dernevik, L; Aljassim, Obaid; Skrbic, Biljana; Rådberg, Göran; Roberts, Donald

doi:10.1016/j.ejcts.2004.08.009

Cited by 66 publications

(66 citation statements)

References 15 publications

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“…Using an autologous fibrin sealant (AFS) is a new procedure. Although AFS is preferred mostly in urological, pulmonary and cardiothoracic surgeries, there is no previous data in the literature about usage in skull base reconstruction (2,14,24,32). Thus, this study is the first evaluation of using an AFS for the prevention of CSF leakage following EETS for large skull base and diaphragma sellae defects.…”

Section: Introductionmentioning

confidence: 99%

Using an autologous fibrin sealant in the preventing of cerebrospinal fluid leak with large skull base defect following endoscopic endonasal transsphenoidal surgery

Yıldırım

Dursun²,

Özdöl³

et al. 2013

Turkish Neurosurgery

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AIm: Postoperative cerebrospinal fluid (CSF) leak following endoscopic endonasal transsphenoidal surgery (EETS) is associated with increased morbidity and mortality. This prospective study is the first evaluation of using autologous fibrin sealant for preventing postoperative CSF leak and related complications. mAterIAl and methOds: 200 endoscopic endonasal transsphenoidal approaches were included in the study and reviewed retrospectively from September 2010 to June 2012. A total of 55 patients who have large skull base and diafragma sella defects, connected with basal cisterns or ventricles, were chosen for the study. The patients were operated via extended or classical endoscopic endonasal transsphenoidal approach. The skull base has been repaired using AFS combined with multilayer reconstruction in all cases. The incidence of CSF leak as a complication of EETS was analyzed. results:The ages of the patients ranged from 20 to 83 years (mean 49.3 years). There were 25 (46%) male patients and 30 (54%) females. All patients had tumors with suprasellar or parasellar extension. Postoperative CSF leak was determined in 2 patients (3.6%). There were no complications and allergic reactions associated with the use of AFS.COnClusIOn: Using of AFS combined with multilayer reconstruction technique is a safe and effective method to prevent CSF leak in large defects following EETS.

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Section: Introductionmentioning

confidence: 99%

Using an autologous fibrin sealant in the preventing of cerebrospinal fluid leak with large skull base defect following endoscopic endonasal transsphenoidal surgery

Yıldırım

Dursun²,

Özdöl³

et al. 2013

Turkish Neurosurgery

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“…Most publications on fibrin sealants have dealt with their use in the prevention or the limitation of autologous blood loss [1, 2] and have involved cardiovascular, orthopedic, thoracic, hepatic, pulmonary as well as orthodontic surgery [3, 4] and, more recently, colonic and gastroenteric anastomoses in bariatric surgery [5]. In pancreatic surgery, sealants have most often been used with the intent to prevent pancreatic fistula after pancreatic surgery, as early as 1978 [6].…”

Section: Introductionmentioning

confidence: 99%

Use of Sealants in Pancreatic Surgery: Critical Appraisal of the Literature

et al. 2009

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Background/Aims: Fibrin sealants containing both fibrin and thrombin have been used to control bleeding, reinforce suture lines and enhance tissue healing. However, the literature provides contradictory results. Methods: A systematic literature search was performed to determine the use of fibrin sealants in pancreatic surgery. These articles were then critically appraised according to their methodologies, outcomes and conclusions. Results: Twenty-four studies were found, including 6 controlled randomized trials. Of these, 16 studies were analyzed. Many methodological flaws and lack of consistency in definitions were found, making comparisons between studies difficult if not impossible. Conclusion: Because of the heterogeneity and lack of high-level evidence, the current literature does not allow us any conclusion: neither is there proof that fibrin sealants are of any real utility in pancreatic surgery, nor that they do not work. Further large-scale controlled trials are necessary before concluding that they do or do not provide any advantages in pancreatic surgery.

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“…This complication leads to an increased risk for development of pneumothorax, bronchopleural fistulae, infections and, consequently, a prolonged hospital stay and higher healthcare costs. Although advances in surgical techniques, including the use of stapling devices, have reduced the incidence of this complication, it is still threatening thoracic surgeons [8].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, a variety of surgical sealants such as fibrin sealants, collagen fleece-bound sealants, autologous blood patches and synthetic glues, have been introduced to shorten postoperative air leaks [2,4,[6][7][8][9]. Fibrin sealants (Tisseel, Baxter Biosciences, Vienna, Austria) are biological sealants which can be safely used for hemostasis and tissue sealing [7,10].…”

Section: Introductionmentioning

confidence: 99%

The effect of fibrin sealant spraying on prolonged air leak after pulmonary resections: a single center experience

Kumbasar¹,

Yilmaz²,

Ozercan³

et al. 2017

Curr Thorac Surg

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The effect of autologous fibrin sealant (Vivostat�) on morbidity after pulmonary lobectomy: a prospective randomised, blinded study

Abstract: Vivostat fibrin sealant significantly reduces post-surgical air leakage and drainage volumes following lobectomy in pulmonary surgery and is suitable for routine use in this procedure.

Cited by 66 publications

References 15 publications

Using an autologous fibrin sealant in the preventing of cerebrospinal fluid leak with large skull base defect following endoscopic endonasal transsphenoidal surgery

Using an autologous fibrin sealant in the preventing of cerebrospinal fluid leak with large skull base defect following endoscopic endonasal transsphenoidal surgery

Use of Sealants in Pancreatic Surgery: Critical Appraisal of the Literature

The effect of fibrin sealant spraying on prolonged air leak after pulmonary resections: a single center experience

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