The effect of autoxidation on the wettability of a linoleic acid monolayer

Trice, William H

doi:10.1016/0095-8522(65)90021-8

Cited by 5 publications

(1 citation statement)

References 80 publications

(138 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fixation with O s 0 4 , K-dichromate, or KMn04 may preserve membrane structure by polymerization of the constituents and formation of insoluble complexes. In vitro studies have also shown that oxidation of unsaturated lipids may cause stabilization of membranes and polymerization (6, 7). Furthermore, oxidation in vivo is known sometimes t o result in polymerization rather than in fragmentation of lipid micelles with consequent formation of lipid pigment granules.…”

Section: Introductionmentioning

confidence: 99%

Oxidation of lipids and membranes II: Effects of oxidants on cerebral white matter homogenates

Bubis

Wolman

1975

J Supramol Struct

View full text Add to dashboard Cite

Bovine cerebral white matter homogenates were oxidized by various oxidizing solutions of equal molarity and subsequently extracted with water. Most of the oxidants tested (K-dichromate, FeCL3, H2O2, O2, and chloroperbenzoic, ascorbic, performic, and periodic acids) rendered the various myelin constituents less extractable than the constituents of unoxidized control homogenates. KMnO4, and to a lesser degree hemoglobin, rendered myelin constituents more extractable with water than those of the control homogenates. The findings indicate that most of the oxidants produced stabilization of the lamellar pattern, probably through cross-linking and polymerization. KMnO4 and hemoglobin caused labilization and breakdown of the membranous structure. Proof that stabilization of membranes is caused by some oxidants and that fragmentation occurs by the action of KMnO4 and hemoglobin was obtained by the light scattering technique and by electron microscopy of the oxidized homogenates. Evidence obtained indicated that formation of hydrophobic end groups during oxidation favors polymerization, while prevalence of hydrophilic groups is associated with fragmentation.

show abstract

Section: Introductionmentioning

confidence: 99%

Oxidation of lipids and membranes II: Effects of oxidants on cerebral white matter homogenates

Bubis

Wolman

1975

J Supramol Struct

View full text Add to dashboard Cite

show abstract

The autoxidative contraction of monolayers of linoleic acid at a gas‐water interface

Porter

Henick

Clifford

1967

J Americ Oil Chem Soc

View full text Add to dashboard Cite

A monolayer of linoleic acid spread at an airwater interface was found to undergo an immediate oxygen‐dependent contraction when compressed at a constant high film pressure. This is in contrast to the expansion of monolayers of other unsaturated acids at lower film pressures as reported by other workers. The process shows quasi‐first‐order kinetics, and there is little evidence for an induction period, in contrast to bulk‐phase autoxidation. Initial rate of contraction is a function of pH between 6 and 9. This and other data suggest that contraction is due to the titration of the packed adjacent carboxyl groups in the monolayer and to the solution of short‐chain soaps resulting from the oxidative scission of linoleic acid. Although complete anaerobiasis prevented film contraction, neitherdl‐alpha‐tocopherol deposited in the film, nor hydroquinone in the substrate solution were inhibitory alone. Butylated hydroxyanisole (BHA) present in an aerobic gas phase produced inhibition of contraction of linoleic acid films spread on completely deaerated substrates. Inhibition was released upon removal of the BHA vapor, the restored rate in air approaching that before the BHA treatment. A method of specific testing of antioxidants is thus provided, which will differentiate between those presented in the vapor, the lipid, or the solution phases.

show abstract

Surface Chemistry of Lipids1 1Lamont-Doherty Geological Observatory Contribution No. 1516.

Shah

1970

Advances in Lipid Research

View full text Add to dashboard Cite

The effect of autoxidation on the wettability of a linoleic acid monolayer

Cited by 5 publications

References 80 publications

Oxidation of lipids and membranes II: Effects of oxidants on cerebral white matter homogenates

Oxidation of lipids and membranes II: Effects of oxidants on cerebral white matter homogenates

The autoxidative contraction of monolayers of linoleic acid at a gas‐water interface

Surface Chemistry of Lipids1 1Lamont-Doherty Geological Observatory Contribution No. 1516.

Contact Info

Product

Resources

About