The Effect of Azithromycin on Relapse in Patients with Moderate-Severe Chronic Graft Versus Host Disease (CGVHD)

Shamoun, Mark; Braun, Thomas; Magenau, John; Choi, Sung W.; Reddy, Pavan; Pawarode, Attaphol; Riwes, Mary; Kitko, Carrie L.; Anand, Sarah; Ghosh, Monalisa; Lugt, Mark Vander; Bonifant, Challice L.; Abusin, Ghada; Parkin, Brian; Peltier, Dan; Yanik, Gregory A.

doi:10.1016/j.bbmt.2018.12.097

Cited by 6 publications

(3 citation statements)

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“…Besides preventing the transpeptidation/translocation process as well as the synthesis of the 50S ribosomal subunit, it prevents the production of proteins . Recent studies have identified azithromycin as a potential approach to stopping the proliferation of HeLa and SGC-7901 cancerous cells by causing them to undergo a process known as apoptosis . Azithromycin (AZM) promotes autophagy.…”

Section: Classification Of Antibiotics and Their Various Roles In Cancermentioning

confidence: 99%

“… 132 Recent studies have identified azithromycin as a potential approach to stopping the proliferation of HeLa and SGC-7901 cancerous cells by causing them to undergo a process known as apoptosis. 133 Azithromycin (AZM) promotes autophagy. Furthermore, it has been observed that antibiotics may influence tumor formation by targeting mitochondria and destroying cancer stem cells.…”

Section: Classification Of Antibiotics and Their Various Roles In Cancermentioning

confidence: 99%

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Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery

Bano,

Parveen,

Saeed

et al. 2024

ACS Omega

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Section: Classification Of Antibiotics and Their Various Roles In Cancermentioning

confidence: 99%

Section: Classification Of Antibiotics and Their Various Roles In Cancermentioning

confidence: 99%

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery

Bano,

Parveen,

Saeed

et al. 2024

ACS Omega

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“…Surprisingly, a probable antitumor effect of azithromycin was revealed in a study by Shamoun et al [17] published as a short abstract, where a long-term drug administration (14 days) aimed to ameliorate chronic graft-versus-graft disease (GvHD) was accompanied by decreased rates of relapse and improved survivals in a combined group of with acute leukemia, MDS, malignant lymphomas, and chronic leukemia patients.…”

Section: Review Articles Ctt Journal | Volume 8 | Number 1 | March-apmentioning

confidence: 99%

Drug repurposing in leukemia treatment and hematopoietic stem cell transplantation

Чухловин¹

2019

CTT

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Over last decade, a number of studies has concerned possible implications of "old" medical drugs, as additional tools for cancer treatment. The main reasons for extension of drug indications are as follows: (1) limited efficiency or high costs of targeted oncogene protein inhibitors or specific monoclonal antibodies for therapy; (2) new molecular targets were revealed for some drugs traditionally used to other therapeutic purposes; and (3) sufficient decline of development costs for the new therapies performed by the "old" drugs. The list of such repurposed drugs now includes dozens of medications commonly used for treatment of cardiovascular diseases, diabetes mellitus, epilepsia, different inflammatory disorders. The present review deals, mainly, repurposing of anti-infectious drugs, including those used in prevention and management of infectious complications occurring in cytostatic therapy of leukemia and lymphomas, e.g., tetracyclines, erythromycin derivatives, as well as fluoroquinolones, antiviral compounds etc. The antitumor effects were of these candidates for repurposing were demonstrated upon screening of their cytostatic effects in leukemic and other cancer cell lines. Some studies were performed in experimental tumor-bearing animals. Only few clinical trials were carried out in patients with leukemias and lymphomas following hematopoietic stem cell transplantation (HSCT), which showed some positive effects of antibacterial drugs in terms of graft-versus-host disease (GvHD) prevention, or prolonged survival of the patients. Controlled clinical trials of common anti-infectious drugs are required for this repurposing.

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Pulmonary and Critical Care Considerations in Pediatric Hematopoietic Stem Cell Transplantation Patient

Ktena

Cooke

2023

Pulmonary and Critical Care Considerations of Hematopoietic Stem Cell Transplantation

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The Effect of Azithromycin on Relapse in Patients with Moderate-Severe Chronic Graft Versus Host Disease (CGVHD)

Cited by 6 publications

References 0 publications

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery

Drug repurposing in leukemia treatment and hematopoietic stem cell transplantation

Pulmonary and Critical Care Considerations in Pediatric Hematopoietic Stem Cell Transplantation Patient

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