2007
DOI: 10.1515/cclm.2007.352
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The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial

Abstract: B-vitamin supplementation had no consistent effects on bone turnover or BMD. However, the situation may be different in patients with hyperhomocysteinemia.

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Cited by 46 publications
(37 citation statements)
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“…However because of small sample size, the power of our study does not permit to prove our hypothesis. Not only our study but also studies with longer duration up to 2 years could not show a significant effect of folic acid supplementation on bone markers [34,39]. Despite a significant reduction of homocysteine levels with folic acid and vitamin B12 supplementation, no significant impact of vitamin B supplementation on bone markers was found in another study while the final level of CTX and alkaline phosphatase was higher in the control group [17].…”
Section: Discussioncontrasting
confidence: 56%
“…However because of small sample size, the power of our study does not permit to prove our hypothesis. Not only our study but also studies with longer duration up to 2 years could not show a significant effect of folic acid supplementation on bone markers [34,39]. Despite a significant reduction of homocysteine levels with folic acid and vitamin B12 supplementation, no significant impact of vitamin B supplementation on bone markers was found in another study while the final level of CTX and alkaline phosphatase was higher in the control group [17].…”
Section: Discussioncontrasting
confidence: 56%
“…Our results are in line with earlier clinical trials where no effect of B vitamins supplementation (1 and 2.5 mg folic acid, 0.5 mg vitamin B12, and 10 or 25 mg vitamin B6) on bone metabolism was found after 1 or 2 years [ 51 , 52 ]. However, subjects with tHcy concentrations > 15 μ mol/L showed an increase in BMD at the lumbar spine, and a decrease in OC and PINP concentrations by approximately 50% after B vitamins treatment [ 51 ]. Similarly, a large scale double blind placebo controlled intervention trial by Sato et al demonstrated a 75% reduction of fracture risk and an improvement of BMD in a 2-year supplementation of folic acid and vitamin B12 in 628 hemiplegic stroke patients with plasma tHcy at baseline of 19.9 μ mol/L [ 53 ].…”
Section: Discussionmentioning
confidence: 93%
“…Supplementation with 2.5 mg of folic acid, 0.5 mg of vitamin B 12 , and 25 mg of vitamin B 6 for 1 year had no effect on markers of bone turnover or BMD in adults with osteoporosis [42]. In contrast, a Japanese study of patients 65 years of age and older providing 5 mg of folic acid and 1500 μg of mecobalamin or placebo daily for 2 years showed an 80% reduction in risk of hip fracture [43].…”
Section: B Vitaminsmentioning
confidence: 93%