The effect of bariatric surgery on renal function

Reid, Tirissa J.; Saeed, Saqib; McCoy, Shiranda; Osewa, Adebola A.; Persaud, Amrita; Ahmed, Leaque

doi:10.1016/j.soard.2014.02.048

Cited by 29 publications

(16 citation statements)

References 26 publications

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“…Nevertheless, bariatric surgery was particularly effective at altering fat mass in our Asian cohort, with serum creatinine remaining constant postsurgery. This is in contrast to European studies where muscle mass was the predominant driver of body composition changes, leading to alteration in serum creatinine [3,4,7]. By extrapolating the known benefits of visceral fat reduction, bariatric surgery in Asians might be more effective in improving renal function compared with Europeans.…”

Section: Discussionmentioning

confidence: 74%

“…Kidney dysfunction is common in obese cohorts [1][2][3][4]. Obesity is also a major risk factor for diabetic kidney disease and the development and progression of chronic kidney disease (CKD) [1][2][3]5].…”

mentioning

confidence: 99%

“…The spectrum of kidney dysfunction in obesity includes glomerular hyperfiltration, proteinuria, and, eventually, glomerular hypofiltration [5,6]. Current literature from non-Asian centers reports improvement in kidney function in obese patients after bariatric surgery [4,7,8].…”

mentioning

confidence: 99%

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Effect of weight loss after bariatric surgery on kidney function in a multiethnic Asian population

Ngoh

Tiong

et al. 2016

Surgery for Obesity and Related Diseases

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Section: Discussionmentioning

confidence: 74%

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of weight loss after bariatric surgery on kidney function in a multiethnic Asian population

Ngoh

Tiong

et al. 2016

Surgery for Obesity and Related Diseases

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“…Due to their outcomes could not be combined with other studies, 2 studies [ 41 , 48 ] were excluded from meta-analysis. 14 studies of 1186 patients with dichotomous data [ 21 , 23 , 24 , 26 , 27 , 29 , 32 – 34 , 38 , 42 , 43 , 45 , 51 ] and 10 studies of 930 patients with continuous data [ 24 , 25 , 29 , 33 , 36 , 37 , 46 , 47 , 49 , 50 ] were included in the meta-analysis of albuminuria and proteinuria. There were only 5 studies of 184 patients [ 25 , 26 , 28 , 40 , 44 ] in the review of CKD II.…”

Section: Resultsmentioning

confidence: 99%

Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

Zou

et al. 2016

PLoS ONE

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BackgroundObesity is an independent risk factor of development and progression of chronic kidney disease (CKD). Data on the benefits of bariatric surgery in obese patients with impaired kidney function have been conflicting.ObjectiveTo explore whether there is improvement in glomerular filtration rate (GFR), proteinuria or albuminuria after bariatric surgery.MethodsWe comprehensively searched the databases of MEDLINE, Embase, web of science and Cochrane for randomized, controlled trials and observational studies that examined bariatric surgery in obese subjects with impaired kidney function. Outcomes included the pre- and post-bariatric surgery GFR, proteinuria and albuminuria. In obese patients with hyperfiltration, we draw conclusions from studies using measured GFR (inulin or iothalamate clearance) unadjusted for BSA only. Study quality was evaluated using the Newcastle-Ottawa Scale.Results32 observational studies met our inclusion criteria, and 30 studies were included in the meta-analysis. No matter in dichotomous data or in dichotomous data, there were statistically significant reduction in hyperfiltration, albuminuria and proteinuria after bariatric surgery.LimitationsThe main limitation of this meta-analysis is the lack of randomized controlled trials (RCTs). Another limitation is the lack of long-term follow-up.ConclusionsBariatric surgery could prevent further decline in renal function by reducing proteinuria, albuminuria and improving glomerular hyperfiltration in obese patients with impaired renal function. However, whether bariatric surgery reverses CKD or delays ESRD progression is still in question, large, randomized prospective studies with a longer follow-up are needed.

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“…There are however conflicting results and the data regarding bariatric surgery was from uncontrolled and non-randomised studies of duration of 1 year or less 28;29 . More recent studies have shown that eGFR was reduced in patients with hyperfiltration and improved in patients with impaired renal function post RYGB and LSG [29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

The impact of bariatric surgery on estimated glomerular filtration rate in patients with type 2 diabetes: a retrospective cohort study

Mirajkar

Bellary

Ahmed

et al. 2016

Surgery for Obesity and Related Diseases

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The effect of bariatric surgery on renal function

Cited by 29 publications

References 26 publications

Effect of weight loss after bariatric surgery on kidney function in a multiethnic Asian population

Effect of weight loss after bariatric surgery on kidney function in a multiethnic Asian population

Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

The impact of bariatric surgery on estimated glomerular filtration rate in patients with type 2 diabetes: a retrospective cohort study

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