The Effect of Baroreflex Function on Blood Pressure Variability

Wei, Xin; Fang, Xing; Ren, Luping; Meng, Yanyan; Zhang, Zixin; Wang, Yongquan; Qi, Guoxian

doi:10.4236/ijcm.2013.49068

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…In addition, this study demonstrated a reduction in the baroreflex control of heart rate in prehypertensive individuals when compared to normotensive individuals, a factor that may also be related to the increased pressure variability and peripheral sympathetic modulation observed. 34 The results of this study corroborate the findings of previous studies 9 , 11 , 13 that also observed reduction of baroreflex sensitivity in prehypertensive patients. However, this is the first to demonstrate autonomic changes in prehypertensive patients with FHSAH in relation to normotensive individuals with the same risk factor.…”

Section: Discussionsupporting

confidence: 92%

Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension

Amaral¹,

Borsato²,

Freitas³

et al. 2017

Arquivos Brasileiros De Cardiologia

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BackgroundIndividuals with a family history of systemic arterial hypertension (FHSAH) and / or prehypertension have a higher risk of developing this pathology.ObjectiveTo evaluate the autonomic and vascular functions of prehypertensive patients with FHSAH.MethodsTwenty-five young volunteers with FHSAH, 14 normotensive and 11 prehypertensive subjects were submitted to vascular function evaluation by forearm vascular conductance(VC) during resting and reactive hyperemia (Hokanson®) and cardiac and peripheral autonomic modulation, quantified, respectively, by spectral analysis of heart rate (ECG) and systolic blood pressure (SBP) (FinometerPRO®). The transfer function analysis was used to measure the gain and response time of baroreflex. The statistical significance adopted was p ≤ 0.05.ResultsPre-hypertensive individuals, in relation to normotensive individuals, have higher VC both at rest (3.48 ± 1.26 vs. 2.67 ± 0.72 units, p = 0.05) and peak reactive hyperemia (25, 02 ± 8.18 vs. 18.66 ± 6.07 units, p = 0.04). The indices of cardiac autonomic modulation were similar between the groups. However, in the peripheral autonomic modulation, greater variability was observed in prehypertensive patients compared to normotensive individuals (9.4 [4.9-12.7] vs. 18.3 [14.8-26.7] mmHg2; p < 0.01) and higher spectral components of very low (6.9 [2.0-11.1] vs. 13.5 [10.7-22.4] mmHg2, p = 0.01) and low frequencies (1.7 [1.0-3.0] vs. 3.0 [2.0-4.0] mmHg2, p = 0.04) of SBP. Additionally, we observed a lower gain of baroreflex control in prehypertensive patients compared to normotensive patients (12.16 ± 4.18 vs. 18.23 ± 7.11 ms/mmHg, p = 0.03), but similar delay time (-1.55 ± 0.66 vs. -1.58 ± 0.72 s, p = 0.90).ConclusionPrehypertensive patients with FHSAH have autonomic dysfunction and increased vascular conductance when compared to normotensive patients with the same risk factor.

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Section: Discussionsupporting

confidence: 92%

Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension

Amaral¹,

Borsato²,

Freitas³

et al. 2017

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

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“…Both of them found that baroreflex function had effects on BPV. Aging and hypertension could increase the arterial stiffness and damage the baroreflex sensitivity, which in turn had influence on BPV [29]. In the Fluckiger's study, they also indicated that the baroreflex gain was negatively associated with age [30].…”

Section: Discussionmentioning

confidence: 95%

“…However, there was no clear physiological mechanism to explain this phenomenon. We speculated the reasons according to Imai [28] and Wei's research works [29] about the BPV. Both of them found that baroreflex function had effects on BPV.…”

Section: Discussionmentioning

confidence: 98%

Age and sex-specific relationships between blood pressure variability and carotid intima-media thickness

Tian

Xiong

et al. 2015

Australas Phys Eng Sci Med

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This study evaluated the association between carotid intima-media thickness (IMT) and 24 h ambulatory blood pressure variability (BPV) in 150 subjects. The subjects were divided into different age groups and gender groups. We found that for the subjects aged less than 45 years, 24 h and daytime diastolic BPV were associated with the increased IMT (r = 0.525, P = 0.018; r = 0.507, P = 0.022). For the middle aged people (46-55 years), daytime (r = 0.377, P = 0.014) and 24 h systolic BPV (r = 0.366, P = 0.017) were more related to the increases in IMT than 24 h diastolic BPV (r = 0.320, P = 0.039). However, no association between carotid IMT and BPV was found in the elderly (>55 years). In addition, the relationships between carotid IMT and BPV were more obvious in males than females. 24 h systolic BPV (P = 0.008) is the independent factor to evaluate the increased carotid IMT for males, but not for females. The findings in our study indicated that age and sex had influences on progression of carotid IMT. We conclude that the relationship between carotid IMT and ambulatory BPV can be modified by age and sex, thus, the regression model using BPV to evaluate the arteriosclerotic progression should take age and sex into account.

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“…However, the BP level in patients with hypertension as a confounding factor may affect the relationship between BPV and cardiovascular disease. Previous study had showed that hypertension could increase the arterial stiffness and damage the baroreflex sensitivity, which in turn influenced BPV [21]. Therefore, we analyzed the relationship between BPV and arterial stiffness in participants with prehypertension.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference of the Relationship between Arterial Stiffness and Blood Pressure Variability in Participants in Prehypertension

Yang

Liu

Wang

et al. 2019

International Journal of Hypertension

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Aim. The association of pressure load with elasticity in vascular system has not been studied fully. We proposed a hypothesis whether gender could modify the association of blood pressure variability (BPV) and arterial stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) in prehypertensive patients. Methods. 24h ambulatory blood pressure monitoring (24h-ABPM) and CF-PWV were measured in 723 participants with prehypertension. Univariate and multivariate regression analyses of these clinical and biological parameters were performed in total population, male and female. Results. A total of 723 participants (mean age 59.76 ± 12.37years, male 329 and female 394) were enrolled into the study. Compared with female, body mass index (BMI), fasting plasma glucose (FPG), uric acid (UA), and homocysteine (HCY) were significantly higher (all p < 0.05). Arterial stiffness (CF-PWV, male versus female, 10.89 ± 2.50 versus 10.33 ± 2.13 m/s, p=0.004) and BPVs (male versus female, 24 h SBPV 13.2 ± 5.11 versus 13.03 ± 5.20; 24 h DBPV 10.34 ± 3.87 versus 9.64 ± 3.59; N SBPV 11.90 ± 6.60 versus 10.94 ± 4.79; N DBPV 9.64 ± 5.87 versus 8.20 ± 4.48, all p<0.05) were higher in male. Multivariable linear regression analysis showed that 24 h BPV were linearly and positively related to CF-PWV in total population (24h SBPV, B=0.033; 24 h DBPV, B=0.035, both P<0.05) and female (24h SBPV, B=0.041; 24h DBPV, B=0.067, both P<0.05) independent of traditional risk factors and medications. Conclusion. BPV was independently associated with arterial stiffness in total population and the relation was modified by gender. 24 h BPVs in prehypertensive patients were useful to identify the early arterial stiffness. Clinical Trials Registration. This trial was registered with Clinical Trials.gov Identifier: NCT02569268.

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The Effect of Baroreflex Function on Blood Pressure Variability

Cited by 4 publications

References 22 publications

Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension

Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension

Age and sex-specific relationships between blood pressure variability and carotid intima-media thickness

Gender Difference of the Relationship between Arterial Stiffness and Blood Pressure Variability in Participants in Prehypertension

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