The effect of basic fibroblast growth factor on scarring

The wound healing, chronic fibrosis, and cancer progression triad

“…In addition, FGF-2 can be induced by TGF-␤ (see above), suggesting an important correlation between the two molecules (177,345). Nonetheless, FGF-2 has also been reported to inhibit TGF-␤-induced myofibroblast differentiation (92, 150,154,234,339). Interestingly, during nonpathological wound healing, FGF-2 inhibits excessive scarring by triggering myofibroblastic apoptosis, yet quiescent (i.e., nonactivated) fibroblasts appear to be refractory to this molecule (1,339).…”

“…Nonetheless, FGF-2 has also been reported to inhibit TGF-␤-induced myofibroblast differentiation (92, 150,154,234,339). Interestingly, during nonpathological wound healing, FGF-2 inhibits excessive scarring by triggering myofibroblastic apoptosis, yet quiescent (i.e., nonactivated) fibroblasts appear to be refractory to this molecule (1,339). These observations suggest that, under physiological conditions, FGF-2 may play a key regulatory role during wound resolution, encouraging fibroblast proliferation to repair damaged tissue but restricting the myofibroblastic population to limit excessive scarring.…”

Basic Study of Appropriate Knot-Tying Force in the Gastrointestinal Tract for Development of Haptic Surgical Robot

“…We therefore selected 0.5 N to 5.0 N as the range of knot-tying forces to test in our study. It has been reported that bFGF may be related to acceleration of angiogenesis, formation of granulation tissue, and proliferation of fibroblasts (Spyrou et al, 2002). In this study we measured the expression of bFGF at the sites of cutting and ligation as a diachronic study and investigated the relationship between knot-tying force and expression of bFGF.…”

Reduction of adhesion formation and promotion of wound healing after laminectomy by pharmacological inhibition of pro-inflammatory cytokines: an experimental study in the rat

“…Since the fibroblasts are responsible for producing collagen much attention has been drawn to the regulation of the fibroblasts in order to reduce scar formation [11][12][13]. Transforming growth factor (TGF), which is an anti-inflammatory cytokine, and fibroblast growth factor (FGF) are known to stimulate the fibroblasts to produce collagen [14][15][16]. Attempts have been made to administer various TGF-inhibitors for this purpose with promising results [17][18][19].…”