The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress

Steptoe, Andrew; Ronaldson, Amy; Kostich, Karen; Lazzarino, Antonio Ivan; Urbanova, Livia; Carvalho, Lívia A.

doi:10.1016/j.bbi.2018.03.027

Cited by 18 publications

(19 citation statements)

References 54 publications

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“…[6,32,33] The depression rate found in this study (30%) was a little bit higher than in the general population (20%) [34] and is probably explained by the cognitive impairment in the glioblastoma population. The interaction of beta-blockers with the adrenergic pathway involved in stress and depression has been the subject of many publications concerning their impact on these pathologies [35][36][37][38] and the proportion of patients treated with beta-blockers in our study seems similar to the proportion observed in the general population (20%). [39] Location of the tumour did not impact stress, especially frontal location that can induce hypersensitivity which can lead to organic depression and anosodiaphoria which can lead to emotional indifference.…”

Section: Discussionsupporting

confidence: 79%

No Impact of Psychosocial Stress on Glioblastoma Development

Durrechou

Engelhardt

Jecko

et al. 2021

Preprint

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Purpose: Psychosocial stress represents an important source of questions in the potential implication of origin of cancer. The aim of the study was to assess stress prevalence prior to diagnosis of wild-type IDH glioblastoma.Methods: This prospective single-center study enrolled consecutive new cases of wild-type IDH glioblastoma diagnosed between December 2019 and March 2021 at the University Hospital of Bordeaux. A standardized patient self-assessment stress questionnaire explored both the presence of stressor exposure and the intensity of patient stress level prior to the diagnosis. Four groups were included: high stressors/high stress, high stressors/low stress, low stressors/low stress, and low stressors/high stress. Patient characteristics were collected. Statistical analysis was based on the Chi-square test and the Kaplan-Meier survival estimator.Results: Sixty-four patients with a median age of 66 years were included. Glioblastoma involved predominantly the frontal lobe (39%). Thirty-six patients (56.3%) presented a low stressor/low stress profile. Stress corresponded mainly to the death of a loved one or to family health problems. Among working professionals, 20 patients (67.5%) reported low-intensity work stress. A history of depression was found in 30%. Progression-free survival at 6 months was 45.3% and median overall survival was estimated to be 16.5 months. Level and presence of stress did not differ based on location of tumour. No association was found between stress and tumour progression or overall survival.Conclusion: A majority of patients in this study had low exposure to stressors as well as low stress level. Psychological stress did not seem to favour the emergence of glioblastoma or survival.

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Section: Discussionsupporting

confidence: 79%

No Impact of Psychosocial Stress on Glioblastoma Development

Durrechou

Engelhardt

Jecko

et al. 2021

Preprint

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“…There are also differences in autonomic reactivity to stress between males and females, with females demonstrating a lower adrenergic response to mental stress than males. 4,5 Repolarization Bazette first noted longer QT interval in females in 1920, 6 and this has been confirmed subsequently. 7…”

Section: Conductionmentioning

confidence: 79%

Arrhythmias in Female Patients: Incidence, Presentation and Management

Zeitler

Poole

Chen

et al. 2022

Circulation Research

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There is a growing appreciation for differences in epidemiology, treatment, and outcomes of cardiovascular conditions by sex. Historically, cardiovascular clinical trials have under-represented females, but findings have nonetheless been applied to clinical care in a sex-agnostic manner. Thus, much of the collective knowledge about sex-specific cardiovascular outcomes result from post hoc and secondary analyses. In some cases, these investigations have revealed important sex-based differences with implications for optimizing care for female patients with arrhythmias. This review explores the available evidence related to cardiac arrhythmia care among females, with emphasis on areas in which important sex differences are known or suggested. Considerations related to improving female enrollment in clinical trials as a way to establish more robust clinical evidence for the treatment of females are discussed. Areas of remaining evidence gaps are provided, and recommendations for areas of future research and specific action items are suggested. The overarching goal is to improve appreciation for sex-based differences in cardiac arrhythmia care as 1 component of a comprehensive plan to optimize arrhythmia care for all patients.

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“…Beta-blockers reduce the mortality in cardiac diseases by attenuating the deleterious effects of sympathetic hyperactivation and increasing the vagal tone [84]. In sepsis, betablockers improve HR control, reduce systemic inflammation, and decrease mortality, acknowledging that their routine use is not yet warranted [85,86].…”

Section: Prognostic Value Of Brainstem Dysfunction and Therapeutic Pementioning

confidence: 99%

Brainstem dysfunction in critically ill patients

et al. 2020

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The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. It controls the sleep-wake cycle and vital functions via the ascending reticular activating system and the autonomic nuclei, respectively. Brainstem dysfunction may lead to sensory and motor deficits, cranial nerve palsies, impairment of consciousness, dysautonomia, and respiratory failure. The brainstem is prone to various primary and secondary insults, resulting in acute or chronic dysfunction. Of particular importance for characterizing brainstem dysfunction and identifying the underlying etiology are a detailed clinical examination, MRI, neurophysiologic tests such as brainstem auditory evoked potentials, and an analysis of the cerebrospinal fluid. Detection of brainstem dysfunction is challenging but of utmost importance in comatose and deeply sedated patients both to guide therapy and to support outcome prediction. In the present review, we summarize the neuroanatomy, clinical syndromes, and diagnostic techniques of critical illness-associated brainstem dysfunction for the critical care setting.

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The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress

Cited by 18 publications

References 54 publications

No Impact of Psychosocial Stress on Glioblastoma Development

No Impact of Psychosocial Stress on Glioblastoma Development

Arrhythmias in Female Patients: Incidence, Presentation and Management

Brainstem dysfunction in critically ill patients

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