The effect of beta blocking drugs on lipid peroxidation in rat heart<i>in vitro</i>

Jenkins, R. R.; Signore, C. M. Del; Sauer, Pieter J. J.; Skelly, Colleen M.

doi:10.1007/bf02536137

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…Previously it was demonstrated in a study by Çiçek et al (16) that this agent might decrease OS that developed secondary to coronary angioplasty. However, there are contradictory studies regarding the antioxidant efficiency of metoprolol in the literature (10, 11). Moreover, Módolo et al (17) discovered that this beta blocker could not protect the kidneys from ischemic episodes in a study performed on dogs.…”

Section: Discussionmentioning

confidence: 99%

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A clinical study about contrast nephropathy: Risk factors and the role of beta blockers

Akgüllü¹,

Eryılmaz²,

Güngör³

et al. 2015

Anatol J Cardiol

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Objective:There is still a group of patient that have unpredictable risk for the development of contrast nephropathy (CN). There is also an effort to find more effficient strategies to prevent CN. Carvedilol, metoprolol and nebivolol seem to have theoretical potentials for the prevention of CN. In this study, we aimed to investigate their effects on the prevention of CN. We also aimed to define the risk factors associated with the development of CN in our study group.Methods:In this prospective, cross-sectional study, the patients were divided into four groups according to whether they were taking 25 mg/day carvedilol (n:56), 5 mg/day nebivolol (n:60), 50 mg/day metoprolol (n:68) or none (n:63). We made analysis to determine the agents’ efficiency on the prevention of CN. We also performed multiple logistic regression analysis including all groups to define the risk factors associated with CN.Results:The incidents of CN were the lowest in the carvedilol group (4%) while the worst performance occurred in those taking metoprolol (10%). The difference between the groups in terms of the development of CN did not reach statistical significance (p>0.05). Multiple logistic regression analysis showed age (p=0.003), higher triglyceride levels (p=0.011) and family history of coronary artery disease (p=0.038) to be the predictors of CN.Conclusion:In this study, we didn’t find any relation between the development of CN and carvedilol, metoprolol or nebivolol usage. We found age, higher levels of triglyceride and family history of coronary artery disease to be risk factors for predicting CN.

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Section: Discussionmentioning

confidence: 99%

“…But, the antioxidant efficiency of this agent may lead to a theoretical potential for the prevention of CN. However, in the literature there are contradictory studies regarding the antioxidant efficiency of metoprolol (10, 11). …”

Section: Introductionmentioning

confidence: 99%

A clinical study about contrast nephropathy: Risk factors and the role of beta blockers

Akgüllü¹,

Eryılmaz²,

Güngör³

et al. 2015

Anatol J Cardiol

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“…This β-blocker was found to be ineffective in protecting the kidneys from ischemic episodes in a study performed on dogs [26]. Yet, metoprolol prevented lipid peroxidation in experimental adult rat hearts, although it was the least effective drug among the lipophilic β-blockers [27]. Tissue studies have demonstrated that nebivolol increases renal blood flow and glomerular filtration rate by causing dilatation in the afferent and efferent arterioles and that it converts reactive oxygen products formed by the nicotinamide adenine dinucleotide phosphate oxidase to NO by way of endothelial constitutive NO synthase and increases the total antioxidant action [28,29].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Carvedilol and Metoprolol for Preventing Contrast-Induced Nephropathy after Coronary Angiography

et al. 2015

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Aims: Contrast-induced nephropathy (CIN) is one of the most common causes of hospital-acquired acute renal failure. Oxidative stress and vasoconstriction might play key roles in its pathogenesis. In a few experimental models, antioxidant properties of carvedilol have been documented. The aim of this study was to analyze and compare the effects of carvedilol and metoprolol on the development of CIN in patients undergoing coronary angiography. Methods: One hundred patients currently taking metoprolol and 100 patients currently taking carvedilol were enrolled into the study. Venous blood samples were obtained before and 48 h after contrast administration. Cystatin C and malondialdehyde values were examined and compared. CIN was defined as a creatinine increase of at least 25% or 0.5 mg/dl from the baseline value. Results: Seven patients in the carvedilol group (7%) and 22 patients in the metoprolol group (22%) developed CIN (p = 0.003). In the metoprolol group, the median cystatin C concentration increased significantly from 978 to 1,086 ng/ml (p = 0.001) 48 h after radiocontrast administration. In the carvedilol group, the median cystatin C concentration did not change significantly (1,143 vs. 1,068 ng/ml; p = 0.94). In the metoprolol group, the mean malondialdehyde concentration increased significantly from 7.09 ± 1.48 to 8.38 ± 2.6 nmol/l (p < 0.001). In the carvedilol group, the mean serum malondialdehyde concentration did not change significantly (7.44 ± 1.21 vs. 7.56 ± 1.11 nmol/l; p = 0.59). Conclusion: When compared to metoprolol, carvedilol might decrease oxidative stress and subsequent development of CIN.

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“…Eight patients out of 20 were receiving antihypertensive drugs (6 metoprolol, 2 atenolol) which have minor influence on oxidative status in vivo (17)(18)(19). The statistical analysis restricted to non-hypertensive patients only did not affect conclusions regarding correlations between the SA content of LDL, oxLDL and autoantibodies to oxLDL in the patients, nor the differences between the patient and the control group (data not shown).…”

Section: Resultsmentioning

confidence: 94%

Relationship between the Sialic Acid Content of Low-Density Lipoprotein (LDL) and Autoantibodies to Oxidized LDL in the Plasma of Healthy Subjects and Patients with Atherosclerosis

Černe

Jürgens²,

Ledinski³

et al. 2002

Clinical Chemistry and Laboratory Medicine

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To determine whether the sialic acid (SA) content of the low-density lipoprotein (LDL) is related to the plasma concentration of autoantibodies to oxidized LDL (oxLDL), we measured the SA content of LDL and the concentrations of oxLDL and autoantibodies to oxLDL in plasma of 20 apparently healthy subjects and 20 patients with advanced coronary atherosclerosis. In the healthy subjects the SA content of LDL correlated positively with plasma concentration of autoantibodies to oxLDL. In agreement with the literature the decreased SA content of LDL was associated with an increased fraction of oxLDL; a decreased fraction of oxLDL was associated with an increased plasma concentration of autoantibodies to oxLDL. In the patients the SA content of LDL and plasma concentrations of oxLDL and autoantibodies to oxLDL were not related. We conclude that the SA content of LDL correlates positively with plasma concentration of autoantibodies to oxLDL in healthy subjects. However, this association may vary depending on the stage of atherogenesis. Although our results suggest dependence of LDL SA content on the clearance of oxidatively modified (desialylated and oxidized) LDL from blood by autoantibodies to oxLDL, the mechanisms regulating the SA content of LDL await further studies.

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The effect of beta blocking drugs on lipid peroxidation in rat heartin vitro

Cited by 16 publications

References 28 publications

A clinical study about contrast nephropathy: Risk factors and the role of beta blockers

A clinical study about contrast nephropathy: Risk factors and the role of beta blockers

Comparison of Carvedilol and Metoprolol for Preventing Contrast-Induced Nephropathy after Coronary Angiography

Relationship between the Sialic Acid Content of Low-Density Lipoprotein (LDL) and Autoantibodies to Oxidized LDL in the Plasma of Healthy Subjects and Patients with Atherosclerosis

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