The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs

Curwain, B P; Holton, Pamela; Spencer, J

doi:10.1111/j.1476-5381.1972.tb06881.x

Cited by 29 publications

(14 citation statements)

References 6 publications

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“…The following results herein argue against this explanation; I ) tetrapeptide-induced secretion in anesthetized dogs was slightly inhibited only with high closes of atropine, 2) the inhibitory effect of vagotomy on tetrapeptide-induced secretion was transient and soon recovered. In this respect, it is interesting to note that isoproterenol has been reported to inhibit pentapeptide-in duced secretion in anesthetized dogs (15), but, on the contrary, enhances histamine-in duced secretion (16). Therefore, the most plausible explanation is that transient pre dominance of sympathetic tone is responsible for the initial inhibition of tetrapeptide and morphine-induced secretion.…”

Section: Discussionmentioning

confidence: 96%

A Comparative Study on the Mechanism of Action of Morphine on Gastric Acid Secretion in Dogs

Endoh

Yamaguchi

1974

Japanese Journal of Pharmacology

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Abstract-While researching the mechanisms of gastric secretagogue action of mor phine, the effects of hexamethonium, atropine and secretin on morphine-induced gastric secretion were studied, and were compared with those on food-, histamine and tetrapeptide-induced gastric secretion in conscious dogs, and on histamine-, tetrapeptide and bethanecol-induced gastric secretion in anesthetized dogs. Effect of acute bilateral vagotomy on the gastric secretion was also investigated in anes thetized dogs.

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Section: Discussionmentioning

confidence: 96%

A Comparative Study on the Mechanism of Action of Morphine on Gastric Acid Secretion in Dogs

Endoh

Yamaguchi

1974

Japanese Journal of Pharmacology

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“…In the present study it was necessary to administer propranolol repeatedly in order to maintain effective 13-receptor blockade probably due to the reported short half-life of propranolol in rats (Faulkner, Hopkins, Boerth, Young, Jellett, Nies, Bender & Shand, 1973). Propranolol alone enhanced the acid secretory effect of pentagastrin in rats as in dogs (Evans & Lin, 1970;Lin & Evans, 1973;Curwain, Holton & Spencer, 1973) and man (Konturek & Oleksy, 1969). The augmentation of acid secretion by propranolol itself invalidates the suggestion that the inhibitory effect of isoprenaline may be mediated by ,B-receptor activation.…”

Section: Discussionmentioning

confidence: 99%

Implication of Gastric Mucosal Histamine in Inhibition by Isoprenaline of Pentagastrin‐induced Gastric Secretion

Lundell

Svensson

1974

British J Pharmacology

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The effect of isoprenaline on pentagastrin‐induced gastric secretion was studied in conscious rats with Heidenhain pouches. The influence of isoprenaline on pentagastrin‐induced release and formation of gastric mucosal histamine was also examined. Isoprenaline strongly inhibited pentagastrin‐induced acid secretion, an inhibition which could not be overcome by increasing the dose of pentagastrin. Propranolol blocked the inhibitory effect of isoprenaline on pentagastrin‐induced acid secretion. Isoprenaline enhanced pepsin secretion induced by pentagastrin, an effect which was blocked by propranolol. Isoprenaline reduced the increase in formation and release of gastric mucosal histamine following pentagastrin infusion, an inhibitory influence which was almost completely blocked by propranolol. The inhibition by isoprenaline of pentagastrin‐induced acid secretion is tentatively related to alterations in gastric mucosal histamine occurring simultaneously.

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“…Noradrenaline probably acts by vasoconstriction whereas isoprenaline directly inhibits the secretory apparatus. Other ,B-adrenoceptor agonists have been shown to act in a similar way to isoprenaline on canine gastric acid secretion (Curwain, Holton & Spencer, 1972).…”

Section: Introductionmentioning

confidence: 99%

Can the Actions of Adrenoceptor Agonists and Antagonists on Pentagastrin‐induced Gastric Secretion Be Due to Their Effects on Histamine Formation?

Curwain

Holton

McIsaac

et al. 1974

British J Pharmacology

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The effects of some adrenoceptor agonists and antagonists which have been reported to affect histamine formation in leucocytes (Assem & Feigenbaum, 1972) have been investigated on gastric secretion in conscious dogs with Heidenhain pouches. Submaximal secretion in response to pentagastrin was enhanced by propranolol (0.1–1.0 mg/kg i.v.) and phenylephrine (1.0 μg kg−1 min−1 i.v. for 20 min), which increase histamine formation, and was decreased by phentolamine (2 mg/kg i.v.) and isoprenaline (0.05–0.2 μg kg−1 min−1 i.v. for 30 min), which decrease histamine formation. Practolol (2 mg/kg i.v.), which has no effect on histamine formation, had no effect on secretion. Acid secretion in response to histamine was either unaffected or affected in the opposite direction by these drugs. The effects of the drugs on pentagastrin‐induced secretion were not secondary to changes in mucosal blood flow (radioactive aniline clearance). The results are consistent with the hypothesis that acid secretion in response to pentagastrin involves the formation of endogenous histamine.

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The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs

Cited by 29 publications

References 6 publications

A Comparative Study on the Mechanism of Action of Morphine on Gastric Acid Secretion in Dogs

A Comparative Study on the Mechanism of Action of Morphine on Gastric Acid Secretion in Dogs

Implication of Gastric Mucosal Histamine in Inhibition by Isoprenaline of Pentagastrin‐induced Gastric Secretion

Can the Actions of Adrenoceptor Agonists and Antagonists on Pentagastrin‐induced Gastric Secretion Be Due to Their Effects on Histamine Formation?

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