The Effect of Bilateral Nephrectomy and Midcollicular Decerebration with Pinealectomy and Hypophysectomy on the Corticosteroid Secretion of Sodium-deficient Sheep *

Blair‐West, J. R.; Coghlan, John P.; Denton, Derek A.; Munro, J. A.; Wintour, Marelyn; Wright, R. D.

doi:10.1172/jci105034

Cited by 20 publications

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References 31 publications

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“…ACTH does play an important role in aldosterone secretion in experiments conducted under anaesthesia and with surgical trauma and blood loss (Davis 1961;Davis et al 1960;Blair-West et al 1964). However, it is established (G-anong 1966;Forsham et al 1961;Blair-West et al 1963) that ACTH stimulation of aldosterone secretion commences when systemic level is adequate to have stimulated cortisol and corticosterone secretion to moderately high levels -35-50 % of adrenal functional capacity to produce these steroids in the case of the sheep.…”

Section: Discussionmentioning

confidence: 99%

Gustatory-Alimentary Reflex Inhibition of Aldosterone Hypersecretion by the Autotransplanted Adrenal Gland of Sodium Deficient Sheep

Denton

Blair‐West

Coghlan

et al. 1977

Acta Endocrinologica

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Several experimental investigators have reported that stimulation of gustatory and alimentary afferents may rapidly influence metabolic and endocrine processes. Changes may precede absorption of materials ingested and anticipate the physiological consequences. A colony of sheep with autotransplanted adrenal glands and a permanent unilateral parotid fistula, have been studied over a perior of 12 years. The effect on corticosteroid secretion of rapid satiation of salt appetite after 24\p=n-\72 h of sodium depletion has been observed. The animals drank 300\p=n-\900 mmol of NaHCO3 solution in 5\p=n-\20 min. Rapid voluntary intake of NaHCO3 caused large evanescent reduction of aldosterone hypersecretion for the 15\p=n-\36 min following satiation. Aldosterone secretion rebounded by 1 h towards control pre-drinking level. It then fell over 2\p=n-\5 h to the Na+ replete range as a result of absorption from the gut of the sodium ingested. The satiation inhibition was seen in the majority, but not all sheep who had had a parotid fistula for several years. The effect was reproducible in the one animal over as long as six years. Analysis of the mechanism showed that it was not due to change of the four factors currently known to be implicated in control of aldosterone secretion viz. plasma [Na], [K], angiotension II and ACTH. The data indicates the action of an unidentified factor in the control of aldosterone secretion \p=m-\ possibly an inhibitor substance originating in the brain.

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Section: Discussionmentioning

confidence: 99%