The Effect of Bile Acids on Hepatic Blood Flow

Grodins, Fred S.; Osborne, Stafford L.; Ivy, A. C.; Goldman, Leon

doi:10.1152/ajplegacy.1941.132.2.375

Cited by 46 publications

(16 citation statements)

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“…The bile salt was infused intra venously at a rate of 30.6 mg/min for 1 h (90 mg/kg/h, a total of 1.8 g), result ing in a 13 % decrease in systemic arterial pressure along with a fourfold increase in bile flow. However, in contrast to this, intravenous infusion in dogs of 500 mg doses (100 mg/min for 5 min) has been reported by Grodins et al (9) to produce a marked increase in bile flow without significant change in systemic arterial pressure. This was accompanied by a 48 % increase in hepatic artery flow, a 29 % decrease in portal flow and a 22 % decrease in superior mesenteric arterial flow.…”

Section: Discussionmentioning

confidence: 85%

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Hepatic, Vascular and Biliary Responses to Infusion of Gastrointestinal Hormones and Bile Salts

Post

Hanson²

1975

Digestion

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The effects of secretin, cholecystokinin, synthetic pentagastrin, sodium dehydrocholate and sodium taurocholate on hemodynamics of the canine liver were studied in a total of 57 dogs. Bile flow was also measured. Dehydrocholate and cholecystokinin significantly decreased systemic arterial pressure while the other substances did not. Hepatic arterial vessels were dilated by pentagastrin and the bile salts; however, flow was not increased in the latter case. Intrahepatic portal venous resistance was decreased by pentagastrin and increased by the bile salts. Portal flow was decreased by the bile salts and increased by pentagastrin. Apart from this, mean changes in portal venous flow and portal pressure were not statistically significant. All were potent choleretic agents except pentagastrin which produced only a relatively small transient increase in bile flow.

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Section: Discussionmentioning

confidence: 85%

“…The effects of sodium dehydrocholate on splanchnic blood flow have been previously studied to some extent (9,14,15). Regan and Horrall ( 17) observed that intravenous injections in 2 g doses when given to dogs produced decreases in systemic arterial pressure as great as 80 mm Hg which in some cases eventually resulted in death.…”

Section: Discussionmentioning

confidence: 99%

Hepatic, Vascular and Biliary Responses to Infusion of Gastrointestinal Hormones and Bile Salts

Post

Hanson²

1975

Digestion

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“…In clinical and experimental obstructive jaundice [4] it has been demonstrated that the bile salts and bile acids appear in the blood in in creasing quantity during the early period of biliary obstruction, but after prolonged obstruction, the concentration diminished, presumably owing to diminished hepatic synthesis. Bile salts have been demonstrated to be vasoactive [13,34], However, these and other possibilities are only con jectures, and at the moment the underlying cause for the early splanch nic response to biliary obstruction is unknown.…”

Section: Discussionmentioning

confidence: 99%

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Ohlsson¹

1971

Eur Surg Res

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Arteriovenous shunting in visceral organs was studied by simultaneous injection of 15 ± 5 and 50 ± 10 (SD) µm microspheres labelled with different isotopes into the left atrium of unanesthetized, unsedated dogs, pentobarbital anesthetized dogs, unanesthetized and unsedated dogs as well as anesthetized dogs subjected to a 1-week’s biliary stasis, and anesthetized dogs subjected to a 6-weeks’ biliary stasis. All dogs showed moderate shunting of the smaller spheres in the stomach. Dogs subjected to a 1-week’s biliary stasis demonstrated signs of shunting also in the jejunum-ileum. All anesthetized dogs, both with and without biliary obstruction, showed signs of substantial shunting outside the visceral area. In dogs subjected to a 1-week’s biliary stasis the liver blood flow was increased owing to increased flow through the hepatic artery.

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“…The relationship between effects of bile acids on hepatic blood flow and on bile formation has not been extensively studied (1,2). Grodin, et al (1) pointed out that effects of bile salts on arterial flow to the liver were not essential for a choleretic response.…”

mentioning

confidence: 99%

“…Grodin, et al (1) pointed out that effects of bile salts on arterial flow to the liver were not essential for a choleretic response. In the present study, we investigated the effects of dehydrocholic acid (DHC), ursodesoxycholic acid (UDC) and chenodesoxycholic acid (CDC) on portal (PBF) and liver-tissue blood flow (LTBF) and on bile formation, and their relationship is discussed.…”

mentioning

confidence: 99%

Effects of Some Bile Acids on Hepatic Blood Flow in Dogs — With Reference to Biliary Excretion

Yamatake

Ishikawa

Yanaura

1976

Japanese Journal of Pharmacology

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The Effect of Bile Acids on Hepatic Blood Flow

Cited by 46 publications

References 0 publications

Hepatic, Vascular and Biliary Responses to Infusion of Gastrointestinal Hormones and Bile Salts

Hepatic, Vascular and Biliary Responses to Infusion of Gastrointestinal Hormones and Bile Salts

Regional Blood Flow Studies with Labelled Microspheres of Different Sizes in Dogs with and without Occlusion of the Common Bile Duct

Effects of Some Bile Acids on Hepatic Blood Flow in Dogs — With Reference to Biliary Excretion

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