The Effect of Biocomposite Grafting Material on Calvarial Bone Regeneration (An Experimental Study)

Abstract

INTRODUCTION: regenerating bone deficiencies produced by trauma or periodontal disorder is a major objective. The surgeon constantly seeks to collect enough bone to finish his tasks as well as to replace the amount of bone that has been lost. In oral surgery, bone grafting is a method frequently employed to make up for lost hard tissue. AIM OF THE STUDY: comparing the bone healing rate of critical defect sizes in the calvaria rabbit with and without using a bio-composite material, both histopathologically and histomorphometrically. MATERIALS AND METHODS: Two bone deficiencies were prepared on the Rabbits' calvaria of. The right-handed defect was the control and the left-handed defect was the study group in all of the rabbits. The control had the defect left without anything, while the study group was received biocomposite material (bone collagen, bone sulfated glycosaminoglycans sulphated glucosamine glycans (sGAG) and hydroxyapatite in natural form). At 2, 4, 6 weeks intervals, the animals were euthanized. RESULTS:The histopathological and histomorphometric results revealed a new bone formation in both groups, the study group showed enhanced quality and quantity. CONCLUSION: The current histological and histomorphological investigation of rabbit cranial bone deficiencies after treating with the test resorbable alloplastic graft showed an excellent biocompatibility of both the biomaterial and the distinct newly formed bone after a 6 weeks period of healing.