The Effect of Biodiesel Feedstock on Regulated Emissions in Chassis Dynamometer Tests of a Pickup Truck

Peterson, C. L.; Taberski, J. S.; Jc, Thompson; Chase, C. L.

doi:10.13031/2013.3034

Cited by 125 publications

(98 citation statements)

References 3 publications

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“…3A). This result is consistent with microarray analyses that did not identify E2F family members as targets of SWI/SNF (35) and suggests that limitation of E2F expression does not underlie the resistance to RB pathway activation in SW13 cells. Therefore, several approaches were utilized to subsequently delineate the role of SWI/SNF on the functional interaction of E2F with chromatin.…”

Section: Swi/snf Is Dispensable For the Assembly Of E2f Or Pocket Prosupporting

confidence: 86%

“…SWI/SNF is a heterogeneous multisubunit chromatin remodeling complex (35,36). This complex utilizes the energy of ATP to remodel chromatin structure and contains either BRG1 or BRM as the central ATPase (36).…”

mentioning

confidence: 99%

“…This complex utilizes the energy of ATP to remodel chromatin structure and contains either BRG1 or BRM as the central ATPase (36). The activity of the core ATPase subunit is required by the SWI/SNF complex to regulate gene transcription (35,37,38). Prior studies have demonstrated that the combined losses of BRG1 and BRM result in resistance to the activation of the RB pathway and aberrant cell cycle progression (32,33).…”

mentioning

confidence: 99%

“…cyclin A). Based on studies in yeast, the loss of SWI/SNF could disrupt virtually any step associated with transcriptional repression (35,38). For example, SWI/SNF could be required for the assembly of E2F proteins at promoter, for the retention of RB or related proteins at the promoter, or for subsequent modifications of the promoter.…”

mentioning

confidence: 99%

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Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1

Gunawardena¹,

Siddiqui²,

Solomon

et al. 2004

Journal of Biological Chemistry

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Plk1 (Polo-like kinase 1) is a critical regulator of cell cycle progression that harbors oncogenic activity and exhibits aberrant expression in multiple tumors. However, the mechanism through which Plk1 expression is regulated has not been extensively studied. Here we demonstrate that Plk1 is a target of the retinoblastoma tumor suppressor (RB) pathway. Activation of RB and related pocket proteins p107/p130 mediate attenuation of Plk1. Conversely, RB loss deregulates the control of Plk1 expression. RB pathway activation resulted in the repression of Plk1 promoter activity, and this action was dependent on the SWI/SNF chromatin remodeling complex. Although SWI/SNF subunits are lost during tumorigenesis and cooperate with RB for transcriptional repression, the mechanism through which SWI/ SNF impinges on RB action is unresolved. Therefore, we delineated the requirement of SWI/SNF for three critical facets of Plk1 promoter regulation: transcription factor binding, corepressor binding, and histone modification. We find that E2F4 and pocket protein association with the Plk1 promoter is independent of SWI/SNF. However, these analyses revealed that SWI/SNF is required for histone deacetylation of the Plk1 promoter. The importance of SWI/SNF-dependent histone deacetylation of the Plk1 promoter was evident, because blockade of this event restored Plk1 expression in the presence of active RB. In summary, these data demonstrate that Plk1 is a target of the RB pathway. Moreover, these findings demonstrate a hierarchical role for SWI/SNF in the control of promoter activity through histone modification.

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Section: Swi/snf Is Dispensable For the Assembly Of E2f Or Pocket Prosupporting

confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1

Gunawardena¹,

Siddiqui²,

Solomon

et al. 2004

Journal of Biological Chemistry

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show abstract

“…The temporal and spatial expression pattern for each subclass of chromatin remodeling complex is differentially regulated, suggesting cell-and tissue type-specific functions. In addition to remodeling activity, proteins within these large complexes have been shown to interact directly with both basal transcriptional machinery and gene-specific DNA-binding factors (17). By opening chromatin and recruiting transcription regulators, these complexes are believed to be key regulators of gene transcription during development.…”

mentioning

confidence: 99%

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation

Gregg

Willer

Fadool

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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Zebrafish with the young (yng) mutation show a defect in retinal cell differentiation. Here we demonstrate that a mutation in a brahma-related gene (brg1) is responsible for the yng phenotype. Brahma homologues function as essential subunits for SWI͞SNF-type chromatin remodeling complexes. Our analysis indicates that brg1 is required for the wave of mitogen-activated protein kinase activity that precedes retinal cell differentiation. Using specific inhibitors of the mitogen-activated protein kinase pathway we show this signal has a direct role in retinal cell differentiation. Lastly, through investigations of mutants in other chromatin remodeling subunits, we provide genetic evidence for gene and tissue specificity of the Brahma chromatin remodeling complex.zebrafish ͉ mitogen-activated protein kinase ͉ eye development

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Fuel Properties and Performance of Biodiesel

Erhan

Dunn

Knothe

et al. 2008

Biocatalysis and Bioenergy

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The Effect of Biodiesel Feedstock on Regulated Emissions in Chassis Dynamometer Tests of a Pickup Truck

Cited by 125 publications

References 3 publications

Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1

Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation

Fuel Properties and Performance of Biodiesel

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